KnowledgeBase Articles Archive

Methoxymethyl Threofuranosyl Thymidine (4′-MOM-TNA-T) at the T7 Position of the Thrombin-Binding Aptamer Boosts Anticoagulation Activity, Thermal Stability, and Nuclease Resistance

2020 / ACS Omega

The synthesis of 4′-methoxymethyl threofuranosyl (4′-MOM-TNA) thymidine and derived oligomers of the G-rich thrombin-binding aptameric (TBA) sequence is reported. The… Continue reading Methoxymethyl Threofuranosyl Thymidine (4′-MOM-TNA-T) at the T7 Position of the Thrombin-Binding Aptamer Boosts Anticoagulation Activity, Thermal Stability, and Nuclease Resistance

Precise Synthesis of a Homogeneous Thermoresponsive Polymer Network Composed of Four-Branched Star Polymers with a Narrow Molecular Weight Distribution

2020 / Macromolecules

In this study, the synthesis of a star-shaped polymer with a narrow molecular weight distribution and subsequent formation of a… Continue reading Precise Synthesis of a Homogeneous Thermoresponsive Polymer Network Composed of Four-Branched Star Polymers with a Narrow Molecular Weight Distribution

Tyrosinase enzyme Langmuir monolayer: Surface chemistry and spectroscopic study

2020 / Journal of Colloid and Interface Science

This study investigates the surface chemistry properties of the tyrosinase enzyme Langmuir monolayer at air-aqueous interface using sodium chloride in… Continue reading Tyrosinase enzyme Langmuir monolayer: Surface chemistry and spectroscopic study

Exploration of the formation and structure characteristics of a miR-92a promoter G-quadruplex by ESI-MS and CD

2020 / Talanta

Combining electrospray ionization mass spectrometry (ESI-MS) with circular dichroism (CD) spectroscopy, a G-rich sequence from miR-92a promoter region was discovered… Continue reading Exploration of the formation and structure characteristics of a miR-92a promoter G-quadruplex by ESI-MS and CD

Collagen stabilization using ionic liquid functionalised cerium oxide nanoparticle

2020 / International Journal of Biological Macromolecules

Nanoparticles owing to their size have a substantial influence on the biological behavior of collagen, thereby opening new channels to… Continue reading Collagen stabilization using ionic liquid functionalised cerium oxide nanoparticle

Enhanced Activity of the Cellulase Enzyme β-Glucosidase upon Addition of an Azobenzene-Based Surfactant

2020 / ACS Sustainable Chemistry & Engineering

β-Glucosidases catalyze the hydrolysis of cellobiose to glucose, which is often the rate-limiting step in the conversion of cellulose into… Continue reading Enhanced Activity of the Cellulase Enzyme β-Glucosidase upon Addition of an Azobenzene-Based Surfactant

Naïve balance between structural stability and DNA-binding ability of c-Myb R2R3 under physiological ionic conditions

2020 / Biophysical Chemistry

The minimum functional unit of c-Myb for specific DNA binding, c-Myb R2R3, fluctuates largely in solution which is critical for… Continue reading Naïve balance between structural stability and DNA-binding ability of c-Myb R2R3 under physiological ionic conditions

Fibrillar conformation of an apolipoprotein A-I variant involved in amyloidosis and atherosclerosis

2020 / Biochimica et Biophysica Acta (BBA) - General Subjects

Different protein conformations may be involved in the development of clinical manifestations associated with human amyloidosis. Although a fibrillar conformation… Continue reading Fibrillar conformation of an apolipoprotein A-I variant involved in amyloidosis and atherosclerosis

Developing an injectable co-formulation of two antidiabetic drugs: Excipient impact on peptide aggregation and pharmacokinetic properties

2020 / International Journal of Pharmaceutics

Combination therapy in Type 2 Diabetes Mellitus is necessary to achieve tight glycaemic control and reduce complication risk. Current treatment… Continue reading Developing an injectable co-formulation of two antidiabetic drugs: Excipient impact on peptide aggregation and pharmacokinetic properties

Orodispersible Carbamazepine/Hydroxypropyl-β-Cyclodextrin Tablets Obtained by Direct Compression with Five-in-One Co-processed Excipients

2020 / AAPS PharmaSciTech

The development of orodispersible tablets (ODTs) for poorly soluble and poorly flowable drugs via direct compression is still a challenge. This work… Continue reading Orodispersible Carbamazepine/Hydroxypropyl-β-Cyclodextrin Tablets Obtained by Direct Compression with Five-in-One Co-processed Excipients

Preferential Recognition and Extraction to Pentoses over Hexoses by a D6h-Symmetrical Ethynylphenol Macrocycle with Six Inner Phenolic Hydroxy Groups

2020 / Journal of Organic Chemistry

A macrocycle consisting of six ethynylphenol units was developed as a host architecture for saccharides. The rigid framework of the… Continue reading Preferential Recognition and Extraction to Pentoses over Hexoses by a D6h-Symmetrical Ethynylphenol Macrocycle with Six Inner Phenolic Hydroxy Groups

Effects of chemical affinity and injection speed of Se and Te precursors on the development kinetic and optical properties of ternary alloyed CdTe1−xSex nanocrystals

2020 / Journal of Physics and Chemistry of Solids

The fabrication of ternary alloyed CdTe1−xSex nanocrystals (NCs) is strongly influenced by the chemical affinities of Se2− and Te2− ions, which are very… Continue reading Effects of chemical affinity and injection speed of Se and Te precursors on the development kinetic and optical properties of ternary alloyed CdTe1−xSex nanocrystals

A Sensitive Isoniazid Capped Silver Nanoparticles – Selective Colorimetric Fluorescent Sensor for Hg2+ Ions in Aqueous Medium

2020 / Journal of Fluorescence

Novel isonicotinic acid hydrazide functionalized silver nanoparticles (INH-AgNPs) were synthesized by wet chemical method and used for the detection of… Continue reading A Sensitive Isoniazid Capped Silver Nanoparticles – Selective Colorimetric Fluorescent Sensor for Hg2+ Ions in Aqueous Medium

Calcium-Induced Activity and Folding of a Repeat in Toxin Lipase from Antarctic Pseudomonas fluorescens Strain AMS8

2020 / Toxins

It is hypothesized that the Ca2+ ions were involved in the activity, folding and stabilization of many protein structures. Many of… Continue reading Calcium-Induced Activity and Folding of a Repeat in Toxin Lipase from Antarctic Pseudomonas fluorescens Strain AMS8

Early Metastable Assembly during the Stress-Induced Formation of Worm-like Amyloid Fibrils of Nucleic Acid Binding Domains of TDP-43

2020 / Biochemistry

TDP-43 protein travels between the cytosol and the nucleus to perform its nucleic acid binding functions through its two tandem… Continue reading Early Metastable Assembly during the Stress-Induced Formation of Worm-like Amyloid Fibrils of Nucleic Acid Binding Domains of TDP-43

Supramolecular Peptide Hydrogel-Based Soft Neural Interface Augments Brain Signals through a Three-Dimensional Electrical Network

2020 / ACS Nano

Recording neural activity from the living brain is of great interest in neuroscience for interpreting cognitive processing or neurological disorders.… Continue reading Supramolecular Peptide Hydrogel-Based Soft Neural Interface Augments Brain Signals through a Three-Dimensional Electrical Network

Synthesis of novel 1, 10-phenanthroline derivatives and it used as probes for sensitive detection of Zn2 and Cd2 metal ions–Spectroscopic and theoretical approach

2020 / Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

A novel class of unexpected 1,10-phenanthrolinederivatives were synthesized from 2,3-dihydroacridin-4(1H)-ones with 3-aminonaphthalen-2-carboxylic acid in presence of phosphorus oxychloride at 130 °C… Continue reading Synthesis of novel 1, 10-phenanthroline derivatives and it used as probes for sensitive detection of Zn2 and Cd2 metal ions–Spectroscopic and theoretical approach

Nucleation-dependent amyloid fibrillation of human GRASP55 in aqueous solution

2020 / European Biophysics Journal

GRASP55, one of the two human GRASP proteins, has been implicated in the organization of Golgi stacks and in unconventional… Continue reading Nucleation-dependent amyloid fibrillation of human GRASP55 in aqueous solution

Peptide Bond Cleavage by Ni(II) Ions within the Nuclear Localization Signal Sequence

2019 / Chemistry & Biodiversity

Nickel is harmful to humans, being both carcinogenic and allergenic. However, the mechanisms of this toxicity are still unresolved. We… Continue reading Peptide Bond Cleavage by Ni(II) Ions within the Nuclear Localization Signal Sequence

Easily accessible axial chiral binaphthalene-triarylborane dyes displaying intense circularly polarized luminescence both in solution and in solid-state

2020 / Dyes and Pigments

The development of small organic CPL-active molecules with large luminescent dissymmetry factors and high quantum yields is highly demanded due… Continue reading Easily accessible axial chiral binaphthalene-triarylborane dyes displaying intense circularly polarized luminescence both in solution and in solid-state

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