Metastatic triple-negative breast cancer is one of the most devastating cancer types. Systemic chemotherapy is necessary, but its clinical performance… Continue reading Self-assembling mertansine prodrug improves tolerability and efficacy of chemotherapy against metastatic triple-negative breast cancer
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
The interaction of Quillaja bark saponin and bovine serum albumin was determined by isothermal titration calorimetry and correlated to the structure, gelation… Continue reading Not sequentially but simultaneously: Facile extraction of proteins and oleosomes from oilseeds
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Wearable sensors for human health, performance, and state monitoring, which have a linear response to the binding of biomarkers found… Continue reading In Silico Discovery and Validation of Neuropeptide-Y-Binding Peptides for Sensors
Leah Pandiscia, PhD
March 24, 2020
A mono-N-substituted probe L containing a bromosalicylaldehyde pendant arm attached to a tetraazamacrocyclic “tet a” moiety was synthesized via straight forward reaction. The… Continue reading Macrocyclic “tet a” derived colorimetric sensor for the detection of mercury cations and hydrogen sulphate anions and its bio-imaging in living cells
Leah Pandiscia, PhD
March 24, 2020
Proteolysis-targeting chimera (PROTAC) could selectively degrade target protein and may become a promising strategy for treating estrogen receptor α (ERα)… Continue reading Development of cell-permeable peptide-based PROTACs targeting estrogen receptor α
Leah Pandiscia, PhD
March 24, 2020
Performing biocatalysis in nonaqueous solvents is advantageous as it imparts enhanced solubility to hydrophobic substrates and an ability to increase… Continue reading Neat Ionic liquid and α-Chymotrypsin-Polymer Surfactant Conjugate-Based Biocatalytic Solvent
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Chiron approach was used to acquire optically pure (R)- and (S)-1-(2,6-dimethylphenoxy)propan-2-ol, immediate precursors of (S)- and (R)-mexiletines, respectively. Two different… Continue reading Enantiodivergent syntheses of (+)- and (−)-1-(2,6-dimethylphenoxy)propan-2-ol: A way to access (+)- and (−)-mexiletine from D-(+)-mannitol
Leah Pandiscia, PhD
March 24, 2020
Coupling of atoms is the basis of chemistry, yielding the beauty and richness of molecules. We utilize semiconductor nanocrystals as… Continue reading Colloidal quantum dot molecules manifesting quantum coupling at room temperature
Leah Pandiscia, PhD
March 24, 2020
Cyanobacteriochromes (CBCRs) are photoreceptor proteins that photoconvert between two parent states and thereby regulate various biological processes. An intriguing property… Continue reading Red, Orange, Green: Light- and Temperature-Dependent Color Tuning in a Cyanobacteriochrome
Leah Pandiscia, PhD
March 24, 2020
Molecular-targeting peptides and mini-proteins are promising alternatives to antibodies in a wide range of applications in bioscience and medicine. We… Continue reading An Immune-Stimulatory Helix–Loop–Helix Peptide: Selective Inhibition of CTLA-4–B7 Interaction
Leah Pandiscia, PhD
March 24, 2020
In this work, three new vanadium complexes are reported. Their synthesis, crystallization and characterization are detailed. The complex (1) [VO(C7H6NO2)2]… Continue reading Synthesis, characterization and structural study of new vanadium complexes with phenolic oxime ligands
Leah Pandiscia, PhD
March 24, 2020
By using La(NO3)3•6H2O, Ca(NO3)2•4H2O, and Mn(CH3COO)2•4H2O as starting raw materials together with methanol, three kinds of La0.67Ca0.33MnO3 (LCMO) solutions, denoted as… Continue reading Fabrication and characterization of micropatterned La0.67Ca0.33MnO3 films via the UV assisted photosensitive solution deposition method
Leah Pandiscia, PhD
March 24, 2020
Enzyme biosensors are useful tools that can monitor rapid changes in metabolite levels in real-time. However, current approaches are largely… Continue reading An artificial metalloenzyme biosensor can detect ethylene gas in fruits and Arabidopsis leaves
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
In bacteria, nucleoid associated proteins (NAPs) take part in active chromosome organization by supercoil management, three-dimensional DNA looping and direct… Continue reading Structural and DNA binding properties of mycobacterial integration host factor mIHF
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020