The three series of 5-mono- and 2,5-bis-1,2,3-triazolyl-substituted benzimidazo[1,2-a]quinolines as potential antitumor agents were synthesized. Their growth-inhibitory activity is influenced by… Continue reading Synthesis, antiproliferative activity and DNA/RNA-binding properties of mono- and bis-(1,2,3-triazolyl)-appended benzimidazo[1,2-a]quinoline derivatives
Leah Pandiscia, PhD
March 24, 2020
By applying caged thymidine residues, DNA duplexes were created in which HgII‐mediated base pair formation can be triggered by irradiation… Continue reading Light‐Induced Formation of Thymine‐Containing Mercury(II)‐Mediated Base Pairs
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Following the information obtained by a rational design study, a cyclic and helical-stabilized analogue of the peptide Cm-p5 was synthetized.… Continue reading Design of a Helical-Stabilized, Cyclic, and Nontoxic Analogue of the Peptide Cm-p5 with Improved Antifungal Activity
Leah Pandiscia, PhD
March 24, 2020
The flavoenzyme D-amino acid oxidase (DAAO) represents a potentially good option for cancer enzyme prodrug therapy as it produces H2O2 using… Continue reading PEG-DAAO conjugate: A promising tool for cancer therapy optimized by protein engineering
Leah Pandiscia, PhD
March 24, 2020
Extra Cytoplasmic Function (ECF) σ factor/regulatory protein (anti-σ factor) pairs govern environment mediated changes in gene expression in bacteria. The… Continue reading Evaluation of specificity determinants in Mycobacterium tuberculosis σ/anti-σ factor interactions
Leah Pandiscia, PhD
March 24, 2020
Phosphorylation could improve functional characteristics of proteins/peptides, and might be used in the functional improvement of herring egg peptides owing… Continue reading Calcium binding to herring egg phosphopeptides: Binding characteristics, conformational structure and intermolecular forces
Leah Pandiscia, PhD
March 24, 2020
Chirality‐based semiconducting nanocrystals, as an emerging area, are envisioned to have great potential in chiral sensing, biomedicine, and chiroptical devices.… Continue reading A Visible‐ and NIR‐Light Responsive Photothermal Therapy Agent by Chirality‐Dependent MoO3−x Nanoparticles
Leah Pandiscia, PhD
March 24, 2020
Twelve new grayanoids (1−12) along with five known compounds were isolated from flowers of Rhododendron molle. Their structures were fully characterized… Continue reading Antinociceptive grayanane-derived diterpenoids from flowers of Rhododendron molle
Leah Pandiscia, PhD
March 24, 2020
Methionine aminopeptidase 1 of Leishmania donovani (LdMetAP1) is a novel antileishmanial target for its role in vital N-terminal methionine processing. After LdMetAP1 expression… Continue reading Synthesis and characterization of quinoline-carbaldehyde derivatives as novel inhibitors for leishmanial methionine aminopeptidase 1
Leah Pandiscia, PhD
March 24, 2020
β-lactoglobulin (β-Lg) has the ability to form three-dimensional networks when heated above denaturation temperature (ca. 76 °C), since it undergoes… Continue reading Suitability of β-lactoglobulin micro- and nanostructures for loading and release of bioactive compounds
Leah Pandiscia, PhD
March 24, 2020
Oxidative transformation of hexapyrrolylbenzenes into azacoronenes using bromine electrophiles as alternative coupling agents is shown to occur according to a… Continue reading Electrophilic Aromatic Coupling of Hexapyrrolylbenzenes. A Mechanistic Analysis
Leah Pandiscia, PhD
March 24, 2020
Three new sulfated isoguanine alkaloid glycosides, locustoside A disulfate (1), saikachinoside B disulfate (2), and saikachinoside A trisulfate (3), have… Continue reading Rare sulfated purine alkaloid glycosides from Bruchidius dorsalis pupal case
Leah Pandiscia, PhD
March 24, 2020
14‐3‐3 proteins bind and modulate the activities of a wide variety of phosphoproteins. Crystal structures of 14‐3‐3 isoforms bound to… Continue reading Two negatively charged invariant residues influence ligand binding and conformational dynamics of 14‐3‐3ζ
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
New tailored copper(II)–based intercalating complexes [Cu(L1)2] (1) and [Cu(L2)2] (2) were synthesized from Schiff base scaffold HL1 and HL2(E)-4-(2-((2-hydroxy-3-methoxybenzylidene)amino)ethyl)benzenesulfonamide and (E)-4-(2-((2-hydroxybenzylidene)amino)ethyl)benzenesulfonamide, respectively. The structure elucidation of complexes 1 and 2 was carried… Continue reading Structure elucidation {spectroscopic, single crystal X-ray diffraction and computational DFT studies} of new tailored benzenesulfonamide derived Schiff base copper(II) intercalating complexes: Comprehensive biological profile {DNA binding, pBR322 DNA cleavage, Topo I inhibition and cytotoxic activity}
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020