The recently discovered Rrf2 family transcriptional regulator RsrR coordinates a [2Fe–2S] cluster. Remarkably, binding of the protein to RsrR-regulated promoter… Continue reading Crystal Structure of the Transcription Regulator RsrR Reveals a [2Fe–2S] Cluster Coordinated by Cys, Glu, and His Residues
Leah Pandiscia, PhD
April 9, 2019
Thiosemicarbazone is a class of compounds with potential applications in medicine, presenting high capacity to inhibit the growth of cancer… Continue reading In vitro and in vivo cytotoxic activity and human serum albumin interaction for a methoxy-styryl-thiosemicarbazone
Leah Pandiscia, PhD
April 9, 2019
The placental growth factor (PlGF), a member of VEGF family, plays a crucial role in pathological angiogenesis, especially ischemia, inflammation,… Continue reading Short PlGF‐derived peptides bind VEGFR‐1 and VEGFR‐2 in vitro and on the surface of endothelial cells
Leah Pandiscia, PhD
April 9, 2019
Nature has developed different protein mediated mechanisms to remodel cellular membranes. One of the proteins that is implicated in these… Continue reading Cooperation of helix insertion and lateral pressure to remodel membranes
Leah Pandiscia, PhD
April 9, 2019
Subcutaneous insulin delivery serves as the major treatment for the ever-increasing spread of type II diabetes worldwide. However, long-term exposure to insulin… Continue reading Sequence specificity of amylin-insulin interaction: a fragment-based insulin fibrillation inhibition study
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019
One of the most stable quadruplexes is formed by the G3T sequence (GGGTGGGTGGGTGGG) that folds into a parallel quadruplex with… Continue reading Stability Factors of the Parallel Quadruplexes: DNA Versus RNA
Leah Pandiscia, PhD
April 9, 2019
This paper reports the synthesis of a planar-chiral monohydroxy-functionalized pillar[5]arene amenable to a wide variety of chemical modifications. Chiral resolution… Continue reading Chiral discrimination of 2-heptlyaminium salt by planar-chiral monohydroxy-functionalized pillar[5]arenes
Leah Pandiscia, PhD
April 9, 2019
A metabolic conversion study on microbes is known as one of the most useful tools to predict the xenobiotic metabolism… Continue reading Biotransformed Metabolites of the Hop Prenylflavanone Isoxanthohumol
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019
In this work, we have studied the effect of Crotalus basiliscus snake venom on the redox reaction of myoglobin (Mb), and by… Continue reading Effect of Crotalus basiliscus snake venom on the redox reaction of myoglobin
Leah Pandiscia, PhD
April 9, 2019
Amyloid aggregation has been associated with numerous human pathological diseases. A recent study has demonstrated that silk fibroin intermittently endorses amyloidogenesis in vivo. In… Continue reading Modulation of aggregation of silk fibroin by synergistic effect of the complex of curcumin and β-cyclodextrin
Leah Pandiscia, PhD
April 9, 2019
Lyotropic bicontinuous cubic (QII) phases have attracted increasing attention as nanostructured fluidic matrices for some bio-polymers including enzymes and DNA.… Continue reading Improvement of lipidic bicontinuous cubic phases by the addition of a zwitterion with strong hydration ability and kosmotropicity
Leah Pandiscia, PhD
April 9, 2019
Protein misfolding plays a critical role in the manifestation of amyloidosis type diseases. Therefore, understanding protein unfolding and the ability… Continue reading Detecting lysozyme unfolding via the fluorescence of lysozyme encapsulated gold nanoclusters
Leah Pandiscia, PhD
April 9, 2019
The mouse Major Urinary Proteins (MUPs) contain a conserved β-barrel structure with a characteristic central hydrophobic pocket that binds a… Continue reading Effects of point mutations in the binding pocket of the mouse major urinary protein MUP20 on ligand affinity and specificity
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019
A wide range of bacterial pathogens have been shown to form biofilms, which significantly increase their resistance to environmental stresses,… Continue reading Physical Determinants of Amyloid Assembly in Biofilm Formation
Leah Pandiscia, PhD
April 9, 2019
The G-quadruplex-forming telomeric sequence (TTAGGG)4TT was investigated by polarized Ultraviolet Resonance Raman Scattering (UVRR) at 266 nm. The presence of… Continue reading Crowding and conformation interplay on human DNA G-quadruplex by ultraviolet resonant Raman scattering
Leah Pandiscia, PhD
April 9, 2019
The aggregation of α-synuclein (α-Syn) has been implicated strongly in Parkinson’s disease (PD). The intrinsically disordered nature of α-Syn makes… Continue reading Modulation of α-Synuclein Aggregation by Cytochrome c Binding and Hetero-dityrosine Adduct Formation
Leah Pandiscia, PhD
April 9, 2019
The molecular interactions between two single-chain lysosomotropic surfactants DMM-11 (2-Dodecanoyloxyethyl)trimethylammonium bromide) and DMPM-11 (2-Dodecanoyloxypropyl)trimethylammonium bromide) with a small heme-protein(cytochrome c (cyt-c)) in Hepes buffer (pH = 7.4)… Continue reading Biomolecular interactions of lysosomotropic surfactants with cytochrome c and its effect on the protein conformation: A biophysical approach
Leah Pandiscia, PhD
April 9, 2019