To systematically determine the effect of N2-heteroaryl modification on the stability of G-quadruplex structures, six types of N2-heteroarylated deoxyguanosines were… Continue reading Tolerance of N2-heteroaryl modifications on guanine bases in a DNA G-quadruplex
Leah Pandiscia, PhD
April 9, 2019
Novel Gemini dodecyl O-glucoside-based primary, secondary, and tertiary vesicles were developed in this work utilizing layer-by-layer deposition of polysaccharides (e.g., sodium… Continue reading Interaction between Gemini Dodecyl O-Glucosides-Based Multilayer Vesicles and β-Lactoglobulin: The Dominant Role of Surface Charge
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019
Cell division by meiosis involves an extraordinary chromosome choreography including pairing, synapsis and crossing over between homologous chromosomes. The many… Continue reading A pseudo-meiotic centrosomal function of TEX12 in cancer
Leah Pandiscia, PhD
April 9, 2019
The reduction in chromosome number during meiosis is essential for the production of haploid germ cells and thereby fertility. To… Continue reading Molecular structure of human synaptonemal complex protein SYCE1
Leah Pandiscia, PhD
April 9, 2019
Stereochemistry is vital for pharmaceutical development and can determine drug efficacy. Herein, 10 pairs of asymmetric triplex metallohelix enantiomers as… Continue reading Stereochemistry and amyloid inhibition: Asymmetric triplex metallohelices enantioselectively bind to Aβ peptide
Leah Pandiscia, PhD
April 9, 2019
In every established species, protein-protein interactions have evolved such that they are fit for purpose. However, the molecular details of… Continue reading Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins
Leah Pandiscia, PhD
April 9, 2019
Bent-core liquid crystal (LC) molecules are known to form mesophases with fascinating polar order and supramolecular chirality despite the achiral… Continue reading Phase behaviors of colloidal analogs of bent-core liquid crystals
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTD) are incurable motor neuron diseases associated with muscle weakness, paralysis and… Continue reading RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019
Chiral nanostructures exhibited distinctive functions and attractive application in complex biological systems, which demonstrated the subject of many outstanding researches.… Continue reading Chiral Nanostructured Composite Films via Solvent-Tuned Self-Assembly and Their Enantioselective Performances
Leah Pandiscia, PhD
April 9, 2019
Der p 2 is a major dust mite allergen and >80% of mite allergic individuals have specifc IgE to this… Continue reading The major allergen Der p 2 is a cholesterol binding protein
Leah Pandiscia, PhD
April 9, 2019
Antimicrobial peptides (AMPs) kill bacteria by targeting their membranes via various mechanisms involving peptide assembly often coupled with disorder‐to‐order structural… Continue reading Manipulating Active Structure and Function of Cationic Antimicrobial Peptide CM15 by the Polysulfonated Drug Suramin: A Step Closer to in vivo Complexity
Leah Pandiscia, PhD
April 9, 2019
Bromo-Noscapine (BrNs) is a tubulin-binding cytotoxic agent with significant activity against breast and lung cancer. The mechanistic interaction insight into… Continue reading Mechanistic Interaction Study of Bromo-Noscapine with Bovine Serum Albumin employing Spectroscopic and Chemoinformatics Approaches
Leah Pandiscia, PhD
April 9, 2019
Zinc ion binding is a principal event in the achievement of the correct fold in classical zinc finger domains since… Continue reading Ni(II), Hg(II), and Pb(II) Coordination in the Prokaryotic Zinc-Finger Ros87
Leah Pandiscia, PhD
April 9, 2019
Two new sesquiterpene-based analogues, namely harzianoic acids A (1) and B (2), were isolated from a sponge-associated fungus Trichoderma harzianum. Their… Continue reading Harzianoic acids A and B, new natural scaffolds with inhibitory effects against hepatitis C virus
Leah Pandiscia, PhD
April 9, 2019
Five new water-soluble amido- and aminoanthraquinone pigments, hypalocrinins A–E (1–5), the new amidoanthraquinone biaryls hypalocrinin F (6) and hypalocrinin G… Continue reading Hypalocrinins, Taurine-Conjugated Anthraquinone and Biaryl Pigments from the Deep Sea Crinoid Hypalocrinus naresianus
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019