In this paper, we present a new synthetic route to produce optically active nanofibers of poly[2-(sec-butyl) aniline] (PSBA). Optically active… Continue reading Optically Active Poly[2-(sec-butyl)aniline] Nanofibers Prepared via Enantioselective Polymerization
Leah Pandiscia, PhD
April 9, 2019
Small heat-shock proteins (sHsps) are ubiquitous molecular chaperones, and sHsp mutations or altered expression are linked to multiple human disease… Continue reading It takes a dimer to tango: Oligomeric small heat shock proteins dissociate to capture substrate
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019
The self-assembly of N- and C-protected tripeptides, Boc-Gly-Phe-Phe-OMe (1) and its analog Boc-Gly-Phg-Phe-OMe (2, Phg = phenylglycine), has been investigated.… Continue reading Unique crystallographic signatures of Boc-Gly-Phe-Phe-OMe and Boc-Gly-Phg-Phe-OMe and their self-association
Leah Pandiscia, PhD
April 9, 2019
SOUL, a heme-binding protein-2 (HEBP-2), interacts with apoptosis-linked gene 2 protein (ALG-2) in a Ca2+-dependent manner. To investigate the properties… Continue reading Thermodynamic Characterization of the Ca2+-Dependent Interaction Between SOUL and ALG-2
Leah Pandiscia, PhD
April 9, 2019
The synthesis of chiral polyoxometalates (POMs) is a challenge because of the difficulty to induce the formation of intrin-sically chiral… Continue reading Stereoselective Assembly of Gigantic Chiral Molybdenum Blue Wheels Using Lanthanide ions and Amino Acids
Leah Pandiscia, PhD
April 9, 2019
Oral delivery of peptide/protein drugs has attracted worldwide attention due to its good patient compliance and convenience of administration. Orally… Continue reading Protein Corona Liposomes Achieve Efficient Oral Insulin Delivery by Overcoming Mucus and Epithelial Barriers
Leah Pandiscia, PhD
April 9, 2019
The carbazole ligand 3 was synthesized, characterized and its binding interactions with human telomeric (22HT) G-quadruplex DNA in Na+ and K+-containing buffer were… Continue reading Binding Study of the Fluorescent Carbazole Derivative with Human Telomeric G-Quadruplexes
Leah Pandiscia, PhD
April 9, 2019
Recent studies have shown that antimicrobial peptides (AMPs) can self-assemble into supramolecular structures, but this has been overlooked as causative… Continue reading Self-assembly dynamics and antimicrobial activity of all L- and D-amino acid enantiomers of a designer peptide
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019
We tested whether a short model peptide derived from a group 3 late embryogenesisabundant (G3LEA) protein is able to maintain the fluorescence activity… Continue reading A LEA model peptide protects the function of a red fluorescent protein in the dry state
Leah Pandiscia, PhD
April 9, 2019
The effect on protein conformation and thermal stability was studied for β-Galactosidase (β-Gal) encapsulated in the nanopores of a silicate matrix (Eβ-Gal). Circular dichroism spectra showed that, compared… Continue reading β-sheet to α-helix conversion and thermal stability of β-Galactosidase encapsulated in a nanoporous silica gel
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019
The size control of nanomedicines for tumor diagnosis and therapy is of high importance, since it enables or disables deep… Continue reading Impact of Branching on the Solution Behavior and Serum Stability of Starlike Block Copolymers
Leah Pandiscia, PhD
April 9, 2019
μ-Conotoxin PIIIA, a peptide toxin isolated from Conus purpurascens, blocks the skeletal muscle voltage-gated sodium channel NaV1.4 with significant potency. PIIIA… Continue reading Role of the disulfide bond on the structure and activity of μ-conotoxin PIIIA in the inhibition of NaV1.4
Leah Pandiscia, PhD
April 9, 2019
Cellulose nanocrystal films with either disordered or chiral nematic structures of varying helical pitch were investigated using 23Na solid-state nuclear magnetic resonance (NMR)… Continue reading Solid-state 23Na NMR spectroscopy studies of ordered and disordered cellulose nanocrystal films
Leah Pandiscia, PhD
April 9, 2019
Two new bisabolane-type sesquiterpenoids, (3R,4S,5R,7S)-3,4,5-trihydroxybisabola-10-ene-9-one (1), (1R,2S,5R,7R,8S)-2,8-epoxy-5-hydroxybisabola-3,10-diene-9-one (2), together with seven known anologues (3–9), were isolated from the cooking liquid… Continue reading Two new bisabolane-type sesquiterpenoids from the cooking liquid of Curcuma longa rhizomes
Leah Pandiscia, PhD
April 9, 2019
A new highly conjugated polymer–bioconjugate poly[9,9-bis(6′-adenine) hexyl)fluorene-co-4,7-(2,1,3 benzothiadiazole)] (PFBT-A) is developed using the well-known Pd(PPh3)4-catalyzed Suzuki cross-coupling polymerization reaction with… Continue reading Polyfluorene-Based Bioconjugates for Selective Detection of Ferritin in Normal and Cancer Human Blood Serums
Leah Pandiscia, PhD
April 9, 2019
Poly (ADP-ribose) polymerase 1 (PARP1) has emerged as an attractive target for cancer therapy due to its key role in… Continue reading Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter
Leah Pandiscia, PhD
April 9, 2019