Transmissible spongiform encephalopathies (TSEs) are a group of fatal neurodegenerative diseases, often referred as prion diseases. TSEs result from the… Continue reading Preparation of lyophilized recombinant prion protein for TSE diagnosis by RT-QuIC
Leah Pandiscia, PhD
April 9, 2019
Polypeptides have broad applications and can be prepared via ring-opening polymerization of α-amino acid N-carboxyanhydrides (NCAs). Conventional initiators, such as primary amines,… Continue reading Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides
Leah Pandiscia, PhD
April 9, 2019
The generally poor mechanical stability of hydrogels limits their use as functional materials for many biomedical applications. In this work,… Continue reading Poly(vinyl alcohol)-induced thixotropy of an L-carnosine-based cytocompatible, tripeptidic hydrogel
Leah Pandiscia, PhD
April 9, 2019
Fabrication of fish gelatin nanofilms was realized by electrospinning using low concentrations of acetic acid, malic acid and citric acid… Continue reading Study of electrospun fish gelatin nanofilms from benign organic acids as solvents
Leah Pandiscia, PhD
April 9, 2019
Cell death-inducing DFF45-like effect (CIDE) domain-containing proteins, DFF40, DFF45, CIDE-A, CIDE-B, and FSP27, play important roles in apoptotic DNA fragmentation… Continue reading Crystal structure and mutation analysis revealed that DREP2 CIDE forms a filament-like structure with features differing from those of DREP4 CIDE
Leah Pandiscia, PhD
April 9, 2019
Proteins in inclusion bodies (IBs) present native-like secondary structures. However, chaotropic agents at denaturing concentrations, which are widely used for… Continue reading Association of high pressure and alkaline condition for solubilization of inclusion bodies and refolding of the NS1 protein from zika virus
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019
Peanuts are most responsible for food‐induced anaphylaxis in adults in developed countries. An effective and safe immunotherapy is urgently needed.… Continue reading Chemically modified peanut extract shows increased safety while maintaining immunogenicity
Leah Pandiscia, PhD
April 9, 2019
Catechol‐O‐methyltransferase (COMT1) catalyzes the transfer of a methyl group from S‐adenosylmethionine (SAM) to various catechol substrates. COMTs play vital roles… Continue reading Functional and structural characterization of a novel catechol‐O‐methyltransferase from Schizosaccharomyces pombe
Leah Pandiscia, PhD
April 9, 2019
Superchiral light, generated by the interference of two counter-propagating circularly polarized light (CPL) with same frequency, opposite handedness and different… Continue reading Dissymmetry enhancement in enantioselective synthesis of helical polydiacetylene by application of superchiral light
Leah Pandiscia, PhD
April 9, 2019
The synthetic peptide T11F (TCRVDHRGLTF), derived from the constant region of human IgM antibodies, proved to exert a significant activity… Continue reading Dissection of the Structural Features of a Fungicidal Antibody-Derived Peptide
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019
Manipulating phase separation structures of thermo-responsive polymers will enhance the usefulness of structure-controllable materials in the fields such as drug… Continue reading Highly ordered polypeptide with UCST phase-separation behavior
Leah Pandiscia, PhD
April 9, 2019
Polysaccharide chromium (III) derivatives are gaining increasing attention in improving type 2 diabetes. In this study, the sulfated polysaccharide from Enteromorpha… Continue reading Characterization and Hypoglycemic Activity of a Rhamnan-Type Sulfated Polysaccharide Derivative
Leah Pandiscia, PhD
April 9, 2019
Thioredoxins (TRXs) are major protein disulfide reductases of the cell. Their redox activity relies on a conserved Trp-Cys-(Gly/Pro)-Pro-Cys active site… Continue reading Structural and Biochemical Insights into the Reactivity of Thioredoxin h1 from Chlamydomonas reinhardtii
Leah Pandiscia, PhD
April 9, 2019
Mercury (Hg) and lead (Pb) are known to be toxic non-radioactive elements, with well-described neurotoxicology. Much evidence supports the implication… Continue reading Concentration-dependent effects of mercury and lead on Aβ42: possible implications for Alzheimer’s disease
Leah Pandiscia, PhD
April 9, 2019
Many intrinsically disordered proteins (IDPs) attain a well-defined structure in a coupled folding and binding reaction with another protein. Such… Continue reading A structurally heterogeneous transition state underlies coupled binding and folding of disordered proteins
Leah Pandiscia, PhD
April 9, 2019
Enzyme engineering tends to focus on the design of active sites for the chemical steps, while the physical steps of… Continue reading Molecular Gating of an Engineered Enzyme Captured in Real Time
Leah Pandiscia, PhD
April 9, 2019
Bioactive metal ions play important roles in both physiological and pathological processes. Developing biosensing probes for bioactive metal ion detection… Continue reading Dual-Aptamer-Conjugated Molecular Modulator for Detecting Bioactive Metal Ions and Inhibiting Metal-Mediated Protein Aggregation
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019