Amyloid fibrillation is associated with several human maladies, such as Alzheimer’s, Parkinson’s, Huntington’s diseases, prions, amyotrophic lateral sclerosis, and type… Continue reading Stabilizing proteins to prevent conformational changes required for amyloid fibril formation
Leah Pandiscia, PhD
October 11, 2018
The bark of Morella salicifolia (Hochst.exA. Rich.) Verdc. &Polhill (Myricaceae) is a common herbal drug and especially utilized by the Maasai community of northeastern… Continue reading Dioic acid glycosides, tannins and methylated ellagic acid glycosides from Morella salicifolia bark
Leah Pandiscia, PhD
October 11, 2018
HIV-1 matrix protein p17 variants (vp17s) detected in HIV-1-infected patients with non-Hodgkin’s lymphoma (HIV-NHL) display, differently from the wild-type protein… Continue reading Identification of amino acid residues critical for the B cell growth-promoting activity of HIV-1 matrix protein p17 variants
Leah Pandiscia, PhD
October 11, 2018
Thymidylate synthase (TSase), an enzyme responsible for the de novo biosynthesis of 2′-deoxythymidine 5′-monophosphate (thymidylate, dTMP) necessary for DNA synthesis,… Continue reading Experimental and computational studies delineate the role for asparagine 177 in hydride transfer for E. coli thymidylate synthase.
Leah Pandiscia, PhD
October 11, 2018
Six new tetracenomycin congeners, saccharothrixones E–I (1–5) and 13-de-O-methyltetracenomycin X (6), were isolated from the rare marine-derived actinomycete Saccharothrix sp. 10-10. Their… Continue reading Seco-Tetracenomycins from the Marine-Derived Actinomycete Saccharothrix sp. 10-10
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Amyloidogenic peptides can self‐assemble into highly ordered nanostructures consisting of cross β‐sheet‐rich networks that exhibit unique physicochemical properties and high… Continue reading Thioflavin T‐Amyloid Hybrid Nanostructure for Biocatalytic Photosynthesis
Leah Pandiscia, PhD
October 11, 2018
Incorporating membrane proteins into membrane mimicking systems is an essential process for biophysical studies and structure determination. Monodisperse lipid nanodiscs… Continue reading Highly Efficient Transfer of 7TM Membrane Protein from Native Membrane to Covalently Circularized Nanodisc
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
ABSTRACT: A multi-technique spectroscopic and theoretical study of the Cp2M(benzenedithiolato) (M=Ti,V,Mo; Cp = η5-C5H5) series provides deep insight into dithiolene… Continue reading Vibrational Control of Covalency Effects Related to the Active Sites of Molybdenum Enzymes
Leah Pandiscia, PhD
October 11, 2018
Sixteen 3,5-dimethylorsellinic acid–based (DMOA-based) meroterpenoids, including 10 new compounds, asperterpenes D–M (1–10), were obtained from Aspergillus terreus. The structures and absolute… Continue reading BACE1 Inhibitory Meroterpenoids from Aspergillus terreus
Leah Pandiscia, PhD
October 11, 2018
Porcine reproductive and respiratory syndrome virus (PRRSV) is a pathogen that severely disrupts swine production. Despite sustained efforts, the disease is… Continue reading Griffithsin inhibits porcine reproductive and respiratory syndrome virus infection in vitro
Leah Pandiscia, PhD
October 11, 2018
Four new medermycin-type naphthoquinones, strepoxepinmycins A–D (1–4), and one known compound, medermycin (5), were identified from Streptomyces sp. XMA39. Their structures were… Continue reading Medermycin-Type Naphthoquinones from the Marine-Derived Streptomyces sp. XMA39
Leah Pandiscia, PhD
October 11, 2018
The regular arrangements of β-strands around a central axis in β-barrels and of α-helices in coiled coils contrast with the… Continue reading De novo design of a fluorescence-activating β-barrel
Leah Pandiscia, PhD
October 11, 2018
Study on the binding properties of helicid by pepsin systematically using multi-spectroscopic techniques and molecular docking method, and these interactions… Continue reading Multi-spectroscopic studies on the interaction between traditional Chinese herb, helicid with pepsin
Leah Pandiscia, PhD
October 11, 2018
AuNPs-DNA probes remain a challenge to recognize the double-stranded DNA(dsDNA) from routine PCR product despite its success in the recognition of… Continue reading A universal colorimetric PCR biosensor based upon triplex formation with the aid of Ru(phen)2dppx2+
Leah Pandiscia, PhD
October 11, 2018
A new dibenzocyclooctadiene lignan, longipedunin E (1), and a new natural product, benzoyl oxokadsuranol (2), together with seven known compounds 3–9,… Continue reading A New Dibenzocyclooctadiene Lignan from Kadsura longipedunculata
Leah Pandiscia, PhD
October 11, 2018
A common problem encountered in enantioselective organocatalysis is the aggregation of the catalyst, which can result in a relevant decrease… Continue reading Organocatalysis and catalyst aggregation: a study using the asymmetric synthesis of benzofuranones as a test reaction
Leah Pandiscia, PhD
October 11, 2018
Heavy metal-associated (HMA) domains bind metal ions at its Cys-x-x-Cys (CxxC) motif and constitute an intracellular network for trafficking of… Continue reading Identification of a novel zinc-binding protein, C1orf123, as an interactor with a heavy metalassociated domain
Leah Pandiscia, PhD
October 11, 2018
Protein lysine acetylation is a widely conserved posttranslational modification in all three domains of life. Lysine acetylation frequently occurs in… Continue reading Lysine Acetylation Regulates Alanyl-tRNA Synthetase Activity in Escherichia coli
Leah Pandiscia, PhD
October 11, 2018