Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Casein, a milk protein that self-assembles to form micelles in aqueous solution, can bind to a wide range of drugs (hydrophilic and… Continue reading Doxorubicin-loaded casein nanoparticles for drug delivery: Preparation, characterization and in vitro evaluation
Leah Pandiscia, PhD
October 11, 2018
Although conjugation with polyethylene glycol (PEGylation) improves the pharmacokinetics of therapeutic proteins, it drastically decreases their bioactivity. Site-specific PEGylation counters… Continue reading A highly bioactive Lys-deficient IFN leads to a site-specific di-PEGylated IFN with equivalent bioactivity to that of unmodified IFN-α2b
Leah Pandiscia, PhD
October 11, 2018
Four new meroterpenoids 1–4 and four new isocoumarinoids 5–8, along with five known isocoumarinoids (9–13), were isolated from the fungus Myrothecium sp. OUCMDZ-2784 associated with… Continue reading Meroterpenoids and Isocoumarinoids from a Myrothecium Fungus Associated with Apocynum venetum
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Bacteriophage T7 uses the thioredoxin of its host, Escherichia coli, to enhance the processivity of its DNA polymerase, a requirement for… Continue reading Hydrophobic Residue in Escherichia coli Thioredoxin Critical for the Processivity of T7 DNA Polymerase
Leah Pandiscia, PhD
October 11, 2018
G-quadruplex (G4), formed by repetitive guanosine-rich sequences, is known to play various key regulatory roles in cells. Herpesviruses containing a… Continue reading Genome-wide analysis of regulatory G-quadruplexes affecting gene expression in human cytomegalovirus
Leah Pandiscia, PhD
October 11, 2018
A series of new liquid crystal (LC) gelators with photo-responsive and AIE properties were synthesized by connecting cholesterol and tetraphenylethylene… Continue reading Liquid crystal gelators with photo-responsive and AIE properties
Leah Pandiscia, PhD
October 11, 2018
Metal nanoclusters (NCs) are a new type of fluorescent nanomaterials composed of several to several tens of metal ions or… Continue reading Realizing Enhanced Luminescence of Silver Nanoclusters-Peptide Soft Hydrogels by PEI Reinforcement
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Chiral supramolecules have great potential for use in chiral recognition, sensing, and catalysis. Particularly, chiral supramolecular biocoordination polymers (SBCPs) provide… Continue reading Chiral self-sorted multifunctional supramolecular biocoordination polymers and their applications in sensors
Leah Pandiscia, PhD
October 11, 2018
Cut190 from Saccharomonospora viridis AHK190 (Cut190) is the only cutinase that exhibits inactive (Ca2+-free) and active (Ca2+-bound) states, although other homologous cutinases… Continue reading Enzymatic hydrolysis of PET: functional roles of three Ca2+ ions bound to a cutinase-like enzyme, Cut190*, and its engineering for improved activity
Leah Pandiscia, PhD
October 11, 2018
Amyloidogenesis of α-synuclein (αS) is considered to be a pathological phenomenon related to Parkinson’s disease (PD). As a key component… Continue reading Morphological Evaluation of Meta-stable Oligomers of α-Synuclein with Small-Angle Neutron Scattering
Leah Pandiscia, PhD
October 11, 2018
Cell penetrating peptides (CPPs) have emerged as powerful tools for delivering bioactive cargoes, such as biosensors or drugs to intact… Continue reading CPProtectides: Rapid uptake of well‐folded β‐hairpin peptides with enhanced resistance to intracellular degradation
Leah Pandiscia, PhD
October 11, 2018
A pair of bisbenzimidazole derivatives as catalytic ligand was evaluated in DNA-based hybrid asymmetric reaction. Similar structure of both ligands… Continue reading Insight into Stereo-Induction by Minor Modification in the Ligand in DNA-Based Hybrid Catalysis
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Microtubules are central elements of the eukaryotic cytoskeleton that often function as part of branched networks. Current models for branching… Continue reading Direct induction of microtubule branching by microtubule nucleation factor SSNA1
Leah Pandiscia, PhD
October 11, 2018
Feline immunodeficiency virus (FIV) is a naturally occurring Lentivirus causing acquired immunodeficiency syndrome in felines. It is considered a useful non-primate model… Continue reading Structural basis of antiviral activity of peptides from MPER of FIV gp36
Leah Pandiscia, PhD
October 11, 2018