The occurrence of triplexes in vivo has been well documented and is determined by the presence of long homopurine-homopyrimidine tracts. The formation… Continue reading Modified RNA triplexes: Thermodynamics, structure and biological potential
Leah Pandiscia, PhD
October 11, 2018
Disulfide‐rich peptides represent an important protein family with broad pharmacological potential. Recent advances in computational methods have made it possible… Continue reading Cytosolic expression, solution structures, and molecular dynamics simulation of genetically encodable disulfide‐rich de novo designed peptides
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
In this work, the interaction of six natural benzo[c]phenanthridine alkaloids (macarpine, sanguilutine, sanguirubine, chelerythrine, sanguinarine and chelirubine) with parallel and… Continue reading Naturally occurring quaternary benzo[c]phenanthridine alkaloids selectively stabilize G-quadruplexes
Leah Pandiscia, PhD
October 11, 2018
Hybrid organic–inorganic perovskites exhibit strong spin–orbit coupling1, spin-dependent optical selection rules2,3 and large Rashba splitting4,5,6,7,8. These characteristics make them promising candidates… Continue reading Spin control in reduced-dimensional chiral perovskites
Leah Pandiscia, PhD
October 11, 2018
A novel turn-off colorimetric sensor for sequence-specific recognition of single-stranded DNA (ssDNA) was established by combining Y-shaped DNA duplex and… Continue reading Turn-off colorimetric sensor for sequence-specific recognition of single-stranded DNA based upon Y-shaped DNA structure
Leah Pandiscia, PhD
October 11, 2018
Antimicrobial peptides (AMPs) such as LL37 are promising alternatives to antibiotics to treat wound infections due to their broad activity,… Continue reading Concentration-Dependent, Membrane-Selective Activity of Human LL37 Peptides Modified with Collagen Binding Domain Sequences
Leah Pandiscia, PhD
October 11, 2018
Multifunctional carbon dots (CDs) with lifetime thermal sensing, nucleolus imaging, and antialgal activity properties were synthesized directly from ascorbic acid… Continue reading Multifunctional carbon dot for lifetime thermal sensing, nucleolus imaging and antialgal activity
Leah Pandiscia, PhD
October 11, 2018
The development of γ-thionorleucine (ThioNle) as a handle for native chemical ligation–desulfurization is reported here. ThioNle is a new addition… Continue reading Native chemical ligation at methionine bioisostere norleucine allows for N-terminal chemical protein ligation
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Because of the unique interaction of radial aromatic blades, propeller-shaped hexaarylbenzenes (HABs) attract much research interest and find various practical… Continue reading Solvent and Temperature Effects on Dynamics and Chiroptical Properties of Propeller Chirality and Toroidal Interaction of Hexaarylbenzenes
Leah Pandiscia, PhD
October 11, 2018
Adenosine Kinase (ADK) regulates the cellular levels of adenosine (ADO) by fine-tuning its metabolic clearance. The transfer of γ-phosphate from… Continue reading Adenosine Kinase couples sensing of cellular potassium depletion to purine metabolism
Leah Pandiscia, PhD
October 11, 2018
Chemical modification of therapeutic peptides is an important approach to improving their physicochemical and pharmacokinetic properties. The triphenylphosphonium (TPP) cation… Continue reading Effect of triphenylphosphonium moiety on spatial structure and biointeractions of stereochemical variants of YRFK motif
Leah Pandiscia, PhD
October 11, 2018
Many patients under therapy with recombinant human erythropoietin (rhuEPO) show resistance to the treatment, an effect likely associated with the… Continue reading Modification of erythropoietin structure by N‐homocysteinylation affects its antiapoptotic and proliferative functions
Leah Pandiscia, PhD
October 11, 2018
An optically active, amphiphilic meta-phenylene ethynylene (m-PE) bearing a chiral amide pendant was designed and synthesized. Living polymerization of m-PE using alkyne-Pd(II)… Continue reading A Facile Synthetic Route to Amphiphilic Poly(Meta-Phenylene Ethynylene) and Poly(Meta-Phenylene Ethynylene)-Block-Polyisocyanide Using a Single Catalyst
Leah Pandiscia, PhD
October 11, 2018
Five new sulfur-enriched alkaloids isatithioetherins A−E (1−5), and two pairs of scalemic enantiomers (+)- and (−)-isatithiopyrin B (6a and 6b) and isoepigoitrin… Continue reading Sulfur-enriched alkaloids from the root of Isatis indigotica
Leah Pandiscia, PhD
October 11, 2018
Guanine oxidation induced by photoirradiation on a pyrene-modified oligonucleotide was investigated under molecular crowding using small cosolutes such as glycerol.… Continue reading Attenuation of guanine oxidation via DNA-mediated electron transfer in crowded environment using small cosolutes
Leah Pandiscia, PhD
October 11, 2018
Sweet proteins are an unexploited resource in the search for non-carbohydrate sweeteners mainly due to their low stability towards heating.… Continue reading Protein stabilization with retained function of monellin using a split GFP system
Leah Pandiscia, PhD
October 11, 2018