Cataract disease results from non-amyloid aggregation of eye lens proteins and is the leading cause of blindness in the world.… Continue reading Mercury-induced aggregation of human lens γ-crystallins reveals a potential role in cataract disease
Leah Pandiscia, PhD
October 11, 2018
Small molecules that intercalate DNA have tremendous therapeutic potential. Typically, DNA intercalators do not alter the overall DNA double helical… Continue reading Intercalator induced DNA superstructure formation: doxorubicin and a synthetic quinoxaline derivative
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
We combine electrostatic polysaccharide/protein complexation with subsequent thermal denaturation of proteins to produce chondroitin sulfate/bovine serum albumin nanoparticles that do not lose… Continue reading Stimuli-responsive nanoparticles by thermal treatment of bovine serum albumin inside its complexes with chondroitin sulfate
Leah Pandiscia, PhD
October 11, 2018
Ovalbumin (OVA) is a major allergen in avian egg white. The objective of this study was to investigate the conjugation… Continue reading Effect of Covalent Interaction with Chlorogenic Acid on the Allergenic Capacity of Ovalbumin
Leah Pandiscia, PhD
October 11, 2018
The 303-residue cytolytic toxin ClyA forms a stable α-helical monomer. In the presence of detergents or membranes, however, the protein… Continue reading Mapping an Equilibrium Folding Intermediate of the Cytolytic Pore Toxin ClyA with Single-Molecule FRET
Leah Pandiscia, PhD
October 11, 2018
Helical structures are ubiquitous in biological materials and often serve a structural purpose. Bioinspired helical materials can be challenging to… Continue reading Self-Assembly of α-Helical Polypeptides into Microscopic and Enantiomorphic Spirals
Leah Pandiscia, PhD
October 11, 2018
Organosilica hybrid materials from bridged silsesquioxanes combine attractive properties of a silica backbone with flexible organic compounds. This class of… Continue reading Diving into the chiral pool: enantiopure microporous polysilsesquioxane spheres from both enantiomers with an oxazolidinone motif
Leah Pandiscia, PhD
October 11, 2018
Arabinoxylan is an abundant polysaccharide in industrially relevant biomasses such as sugarcane, corn stover and grasses. However, the arabinofuranosyl di-substitutions… Continue reading The mechanism by which a distinguishing arabinofuranosidase can cope with internal di-substitutions in arabinoxylans
Leah Pandiscia, PhD
October 11, 2018
MEX‐3C, a novel RNA binding E3 ubiquitin ligases, contains two N‐terminal heterogeneous nuclear ribonucleoprotein K homology (KH) domains and C‐terminal… Continue reading Structural and functional characterization of hMEX‐3C Ring finger domain as an E3 ubiquitin ligase
Leah Pandiscia, PhD
October 11, 2018
The [2Fe–2S] cluster-bridged complex of BOLA3 with GLRX5 has been implicated in cluster trafficking, but cluster exchange involving this heterocomplex… Continue reading Cluster exchange reactivity of [2Fe–2S] cluster-bridged complexes of BOLA3 with monothiol glutaredoxins
Leah Pandiscia, PhD
October 11, 2018
Designing proteins with novel folds remains a major challenge, as the biophysical properties of the target fold are not known a… Continue reading An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture
Leah Pandiscia, PhD
October 11, 2018
Responsive protein hydrogels are known to respond to target external stimuli that cause changes in their properties, attracting considerable attention… Continue reading Responsive Protein Hydrogels Assembled from Spider Silk Carboxyl-Terminal Domain and Resilin Copolymers
Leah Pandiscia, PhD
October 11, 2018
Non-macrocyclic heteroaryls represent a valuable class of ligands for nucleic acid recognition. In this regard, non-macrocyclic pyridyl polyoxazoles and polyoxadiazoles… Continue reading Oxadiazole/Pyridine-Based Ligands: A Structural Tuning for Enhancing G-Quadruplex Binding
Leah Pandiscia, PhD
October 11, 2018
Daptomycin is a phosphatidylglycerol specific, calcium dependent membrane-active antibiotic that has been approved for the treatment of Gram-positive infections. A… Continue reading Comparison of the Effects of Daptomycin on Bacterial and Model Membranes
Leah Pandiscia, PhD
October 11, 2018
Misfolding and aggregation of human islet amyloid polypeptide (hIAPP) into fibrils is an important contribution to the pathology of type… Continue reading Conformation-Dependent Manipulation of Human Islet Amyloid Polypeptide Fibrillation by Shiitake-Derived Lentinan
Leah Pandiscia, PhD
October 11, 2018
The interaction of porcine serum albumin (PSA) with biodegradable, less cytotoxicCm-E2O-Cm gemini surfactants was monitored using state-of-the-art techniques. The temperature variation fluorescence experiments were… Continue reading Biophysical investigation of the interaction between cationic biodegradable Cm-E2O-Cm gemini surfactants and porcine serum albumin (PSA)
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Leah Pandiscia, PhD
October 11, 2018
Ubiquitin‐conjugating (E2) enzymes in protein ubiquitination are associated with various diseases. An artificial RING finger (ARF) is a useful tool,… Continue reading Unique auto‐ubiquitination activities of artificial RING fingers in cancer cells
Leah Pandiscia, PhD
October 11, 2018