Found 9617 Results / Page 244 of 481
2018 / Organic & Biomolecular Chemistry
Double-stranded segments of a genome that can potentially form G-quadruplex (GQ) and/or i-motif (iM) structures are considered to be important… Continue reading Probing the competition between duplex and G-quadruplex/i-motif structures using a conformation-sensitive fluorescent nucleoside probe
2018 / Scientific Reports
Nanobodies represent the variable binding domain of camelid heavy-chain antibodies and are employed in a rapidly growing range of applications… Continue reading The structural basis of nanobody unfolding reversibility and thermoresistance
2018 / Soft Matter
Bovine Serum Albumin (BSA) is one of the most copious and significant blood proteins with dynamic structure. The understanding of… Continue reading Cationic double chained metallosurfactants: Synthesis, aggregation, cytotoxicity, antimicrobial activity and their impact on structure of Bovine serum albumin
2017 / Biochimica et Biophysica Acta (BBA) - General Subjects
The peptide VLL-28, identified in the sequence of an archaeal protein, the transcription factor Stf76 from Sulfolobus islandicus, was previously… Continue reading Insights into the anticancer properties of the first antimicrobial peptide from Archaea
2018 / PLoS ONE
In this study, we report a detailed experimental, binding free energy calculation and molecular dynamics (MD) simulation investigation of the… Continue reading The potential impact of carboxylic-functionalized multi-walled carbon nanotubes on trypsin: A Comprehensive spectroscopic and molecular dynamics simulation study
2018 / Biomacromolecules
We stapled an amphipathic peptide mainly consisting of leucine (L) and lysine (K) by an azobenzene (Ab) linker for photo-control… Continue reading Photo-Switching of Cell Penetration of Amphipathic Peptides by Control of Alpha-Helical Conformation
2018 / Amino Acids
The three-fingered toxin family and more precisely short-chain α-neurotoxins (also known as Type I α-neurotoxins) are crucial in defining the… Continue reading Short-chain consensus alpha-neurotoxin: a synthetic 60-mer peptide with generic traits and enhanced immunogenic properties
2018 / Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
In the chemoreceptive system of insects, there are always some soluble binding proteins, such as some antennal-specific chemosensory proteins (CSPs),… Continue reading Combinatorial multispectral, thermodynamics, docking and site-directed mutagenesis reveal the cognitive characteristics of honey bee chemosensory protein to plant semiochemical
2018 / ACS Biomaterials Science & Engineering
Therapeutic biologics (i.e., proteins) have been widely recognized for the treatment, prevention, and cure of a variety of human diseases… Continue reading Recombinant Spider Silk Hydrogels for Sustained Release of Biologicals
2018 / Communications Chemistry
Proteins undergo both cold and heat denaturation, but often cold denaturation cannot be detected because it occurs at temperatures below… Continue reading The cold denaturation of IscU highlights structure–function dualism in marginally stable proteins
2018 / Journal of Biological Chemistry
The inner membrane-associated protein of 30 kDa (IM30), also known as vesicle-inducing protein in plastids 1 (Vipp1), is found in the majority of photosynthetic… Continue reading Mg2+ -binding triggers rearrangement of the IM30 ring structure, resulting in augmented exposure of hydrophobic surfaces competent for membrane binding
2018 / Organic & Biomolecular Chemistry
The synthesis and the impact of a disulfide bridge between 2′-O-positions of two adjacent nucleotides in an RNA duplex and… Continue reading A 2′,2′-disulfide-bridged dinucleotide conformationally locks RNA hairpins
2017 / Fitoterapia
Five picrotoxane sesquiterpenoids belonging to the unusual dendrobine-type (1 and 4) and the picrotoxinin-type (2, 3, and 5) were isolated from the stems of Dendrobium… Continue reading Picrotoxane sesquiterpenoids from the stems of Dendrobium nobile and their absolute configurations and angiogenesis effect
2017 / Journal of Luminescence
Phloroglucinol and its derivatives possess wide array of biopotentials such as antimicrobial, antioxidant, anti-inflammatory, anticancer and anti-metastatic properties. In the present investigation, for the first time,… Continue reading Molecular interaction between human serum albumin (HSA) and phloroglucinol derivative that shows selective anti-proliferative potential
2017 / Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
The binding mode of thionine (3,7-diamino-5-phenothiazinium) with alternating and non-alternating DNA polynucleotides at low binding ratios was conclusively determined using linear and circular dichroism spectroscopies. The… Continue reading Linear and circular dichroism characterization of thionine binding mode with DNA polynucleotides
2017 / Journal of Trace Elements in Medicine and Biology
Ni(II) stimulates innate immunity via the direct binding to human Toll Like Receptor 4(hTLR4), the bacterial lypopolysaccharide receptor. The binding is specific for humans… Continue reading Ni(II) interaction with a peptide model of the human TLR4 ectodomain
2017 / Molecular Cell
Activation-induced cytidine deaminase (AID) initiates both class switch recombination (CSR) and somatic hypermutation (SHM) in antibody diversification. Mechanisms of AID targeting… Continue reading AID Recognizes Structured DNA for Class Switch Recombination
2018 / Chemistry & Biodiversity
Callistrilones F–K (1–6), six new triketone-phloroglucinol-monoterpene hybrids were isolated from the twigs and leaves of Callistemon rigidus. Their structures with… Continue reading Antiviral Triketone‐Phloroglucinol‐Monoterpene Adducts from Callistemon rigidus
2018 / PLoS ONE
Thrombin binding aptamer (TBA), is a short DNA 15-mer that forms G-quadruplex structure and possesses anticoagulant properties. Some chemical modifications,… Continue reading Novel isoguanine derivative of unlocked nucleic acid—Investigations of thermodynamics and biological potential of modified thrombin binding aptamer
2018 / Chemistry: A European Journal
: In order to investigate the principle of chiral induction from nanometric silica helices to polyoxometalate (POM) clusters, a series… Continue reading Optically Active Polyoxometalate‐based Silica Nanohelices: Induced Chirality from Inorganic Nanohelices to Achiral POM Clusters
