Found 9617 Results / Page 245 of 481
2018 / Scientific Reports
α-synuclein plays a key role in the pathogenesis of Parkinson’s disease (PD); its deposits are found as amyloid fibrils in… Continue reading Oleuropein aglycone stabilizes the monomeric α-synuclein and favours the growth of non-toxic aggregates
2018 / ChemMedChem
In order to determine the eutomers of potent GluN2B selective NMDA receptor antagonists with 3‐benzazepine scaffold, benzyl ethers (S)‐2 and… Continue reading Synthesis and pharmacological evaluation of enantiomerically pure GluN2B selective NMDA receptor antagonists
2018 / Scientific Reports
Oligomeric assembly is a common feature of membrane proteins and often relevant to their physiological functions. Determining the stoichiometry and… Continue reading Oligomeric states of microbial rhodopsins determined by high-speed atomic force microscopy and circular dichroic spectroscopy
2018 / Advanced Science
As a left-handed helical structure, Z-DNA is biologically active and it may be correlated with transcription and genome stability. Until… Continue reading The Cucurbit[7]Uril-Based Supramolecular Chemistry for Reversible B/Z-DNA Transition
2018 / Chemistry A European Journal
A G‐quadruplex forming sequence from the MYC promoter region was modified with syn‐favoring 8‐bromo‐2’‐deoxyguanosine residues. Depending on the number and… Continue reading Loop Length Affects Syn‐Anti Conformational Rearrangements in Parallel G‐Quadruplexes
2018 / PNAS
The allosteric interplay between distant functional sites present in a single protein provides for one of the most important regulatory… Continue reading Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein
2018 / PLoS Genetics
Polymyxin is the last line of defense against severe infections caused by carbapenem-resistant gram-negative pathogens. The emergence of transferable MCR-1/2… Continue reading Defining ICR-Mo, an intrinsic colistin resistance determinant from Moraxella osloensis
2018 / Small
The photo-induced reconfigurable assembly of nanostructures via the simultaneous noncovalent and covalent polymerization of a functional ferrocene-tyrosine (Fc-Y) molecule is… Continue reading Photo-Induced Polymerization and Reconfigurable Assembly of Multifunctional Ferrocene-Tyrosine
2018 / International Journal of Cancer
Suppressor of cytokine signaling (SOCS) family of proteins plays critical role in the regulation of immune responses controlling JAK/STAT mediated… Continue reading Mimetics of Suppressor of cytokine signalling 3: novel potential therapeutics in triple breast cancer
2018 / PLoS ONE
Antimicrobial peptides (AMPs) are a diverse group of molecules which play an important role in the innate immune response. Bovine… Continue reading Antimicrobial activity of bovine NK-lysin-derived peptides on Mycoplasma bovis
2018 / RSC Advances
We have shown that fullerene (C60) becomes soluble in water by mixing fullerene and amyloid β peptide (Aβ40) whose fibril… Continue reading Preparation and photo-induced activities of water-soluble amyloid β-C60 complexes
2018 / ACS Sensors
The construction of sensitive and selective biosensors capable of detecting specific targets in complex biological samples remains a challenge highly… Continue reading Low Fouling Protein Detection in Complex Biological Media Supported by a Designed Multifunctional Peptide
2018 / Soft Matter
Peptide amphiphiles capable of assembling into multidimensional nanostructures have attracted much attention over the past decade due to their potential… Continue reading Dimensional control of supramolecular assemblies of diacetylene-derived peptide gemini amphiphile: from spherical micelles to foamlike networks
2018 / JACS
NsaS is one of four intramembrane histidine kinases (HKs) in Staphylococcus aureus that mediate the pathogen’s response to membrane active… Continue reading Structure and function of the transmembrane domain of NsaS, an antibiotic sensing histidine kinase in S. aureus
2018 / Nature Communications
No efficient treatment exists for nephrotic syndrome (NS), a frequent cause of chronic kidney disease. Here we show mutations in… Continue reading Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment
2018 / The Journal of Organic Chemistry
The reactions of hexaazamacrocycle 1 with 2,6-bis(bromomethyl)pyridine or 2,6-bis[(tosyloxy)methyl)]pyridine in the presence of appropriate carbonates result in the formation of… Continue reading Chiral Cryptates Derived from a Hexa-azamacrocycle
2018 / Scientific Reports
In this paper, we report our investigations on analogues of the anti-human immunodeficiency virus type 1 (HIV-1) integrase (IN) aptamer T30175… Continue reading Improvement of the activity of the anti-HIV-1 integrase aptamer T30175 by introducing a modified thymidine into the loops
2018 / Journal of Agricultural and Food Chemistry
The red color of Edible bird’s nest (EBN) remains a mystery over hundreds of years. Here, different analytical methods were… Continue reading Binding of Fe ion to acidic mammalian chitinase-like protein directs the origin of red color in edible bird’s nest
2018 / Macromolecular Bioscience
Dentin phosphoprotein (DPP) is a major component of the dentin matrix playing crucial role in hydroxyapatite deposition during bone mineralization,… Continue reading Dentin Phosphoprotein Mimetic Peptide Nanofibers Promote Biomineralization
2018 / New Journal of Chemistry
Using enantiopure ligands (–)/(+)-4,5-pinene-2,2ʹ-bipyridine (LR/LS) to react with Dy(btfa)3•2H2O, respectively, a pair of Dy(III) enantiomers with the formulae Dy(btfa)3LR (R-1… Continue reading A pair of mononuclear Dy(III) enantiomers showing single-ion magnet and ferroelectric properties
