Found 9617 Results / Page 284 of 481
2018 / ACS Omega
Engaging Raman spectroscopy as a primary tool, we investigated the early events of insulin fibrilization and determined the structural content… Continue reading Structural Insight of Amyloidogenic Intermediates of Human Insulin
2018 / Journal of Materials Chemistry C
Novel tetraphenylethylene (TPE) triangular macrocycle crown ethers bearing three ether crown rings were synthesized by connecting three TPE crown ether… Continue reading Chiroptical Property of TPE Triangular Macrocycle Crown Ethers from Propeller-Like Chirality Induced by Chiral Acids
2018 / Soft Matter
The complexation of lysozyme with aggregates from two triblock amphiphilic polyelectrolytes of the same blocks but different topologies and block… Continue reading Formation of complexes in aqueous solutions of amphiphilic triblock polyelectrolytes of different topologies and an oppositely charged protein
2018 / Nucleic Acids Research
The DNMT3A R882H mutation is frequently observed in acute myeloid leukemia (AML). It is located in the subunit and DNA… Continue reading The DNMT3A R882H mutant displays altered flanking sequence preferences
2018 / ACS Biomaterials Science & Engineering
Understanding the influence of various physical cues on cell behavior is critical for the design of bioactive biomaterials optimized for… Continue reading Controlling Cell Behavior on Silk Nanofiber Hydrogels with Tunable Anisotropic Structures
2018 / Macromolecules
Controlling the self-assembly of block copolymers with variable chain shape and stiffness is important for driving the self-assembly of functional… Continue reading Impact of Helical Chain Shape in Sequence-Defined Polymers on Polypeptoid Block Copolymer Self-Assembly
2018 / Advanced Healthcare Materials
Cancer vaccines aim to induce a strong major histocompatibility complex class I (MHC‐I)‐restricted CD8+ cytotoxic T‐cell response, which is an important… Continue reading Photothermally Controlled MHC Class I Restricted CD8+ T‐Cell Responses Elicited by Hyaluronic Acid Decorated Gold Nanoparticles as a Vaccine for Cancer Immunotherapy
2018 / Molecular Recognition
In this work, the interaction of an anti‐HIV drug lamivudine and human serum albumin (HSA) was studied by multispectroscopic and… Continue reading Study on the molecular recognition action of lamivudine by human serum albumin
2018 / Scientific Reports
In the past few years, the World Health Organization has been warning that the post-antibiotic era is an increasingly real… Continue reading Antimicrobial Photodynamic therapy enhanced by the peptide aurein 1.2
2018 / Journal of Biological Chemistry
Autosomal recessive juvenile Parkinsonism (ARJP) is an inherited neurodegenerative disease in which 50% of affected individuals harbor mutations in the… Continue reading Impact of altered phosphorylation on loss of function of juvenile Parkinsonism-associated genetic variants of the E3 ligase parkin
2018 / Scientific Reports
The oligomerization and fibrillation of human islet amyloid polypeptide (hIAPP) play a central role in the pathogenesis of type 2… Continue reading Dual effect of PEG-PE micelle over the oligomerization and fibrillation of human islet amyloid polypeptide
2018 / Analytical Methods
Herein we propose a rational design to construct peroxidase mimetics in response to S1 nuclease by employing guanine-rich oligonucleotides and… Continue reading Engineering Oligonucleotide-Based Peroxidase Mimetics for Colorimetric Assay of S1 Nuclease
2018 / Scientific Reports
Hydroxynitrile lyases (HNLs), which are key enzymes in cyanogenesis, catalyze the cleavage of cyanohydrins into carbonyl compounds and hydrogen cyanide.… Continue reading Hydroxynitrile lyases from cyanogenic millipedes: molecular cloning, heterologous expression, and whole-cell biocatalysis for the production of (R)-mandelonitrile
2018 / Scientific Reports
Peptides mimicking the major protein of highdensity lipoprotein (HDL), apolipoprotein A-I (apoA-I), are promising therapeutics for cardiovascular diseases. Similar to… Continue reading Structural properties of apolipoprotein A-I mimetic peptides that promote ABCA1-dependent cholesterol efflux
2018 / Nanoscale
Several works demonstrated the ability of graphene oxide (GO) to efficiently adsorb small-interfering RNA (siRNA) on its surface and to… Continue reading Graphene oxide size and oxidation degree govern its supramolecular interactions with siRNA
2018 / Physical Chemistry Chemical Physics
The modulation of solid-state supramolecular assemblies at room temperature is still challenging even though it potentially has very important application… Continue reading Room temperature chiral reorganization of interfacial assembly of achiral double-decker phthalocyanine
2018 / Physical Chemistry Chemical Physics
Controlling of ligand mediated G-quadruplex DNA (GQ-DNA) formation and stabilization is an important and challenging aspect due to its active… Continue reading Controlling anticancer drug mediated G-quadruplex formation and stabilization by a molecular container
2018 / Chirality
Naringin is a flavanone that widely presents on daily diet and traditional medicinal materials. The ratios of naringin C-2 diastereomers… Continue reading Comprehensive investigation into the interconversion of C-2 diastereomers of naringin
2018 / PLoS Pathogens
Vibrio cholerae is an aquatic gram-negative microbe responsible for cholera, a pandemic disease causing life-threatening diarrheal outbreaks in populations with limited… Continue reading Structural basis of mammalian glycan targeting by Vibrio cholerae cytolysin and biofilm proteins
2018 / Journal of Materials Chemistry B
Quercetin (Que), as one of the most potent flavonoids, has gained appreciable attention in anti-fibrosis, anti-oxidation and other therapeutic research… Continue reading Quercetin nanoparticles with enhanced bioavailability as multifunctional agents toward amyloid induced neurotoxicity
