Found 9617 Results / Page 287 of 481
2018 / International Journal of Molecular Sciences
Tigerinin-1R (Arg–Val–Cys–Ser–Ala–Ile–Pro–Leu–Pro–Ile–Cys–His–NH2), a cationic 12-mer peptide containing a disulfide bond extracted from frog skin secretions, lacks antibacterial activity, but has… Continue reading Role of Disulfide Bonds in Activity and Stability of Tigerinin-1R
2018 / Nucleic Acids Research
Mg2+ ion stimulates the DNA strand exchange reaction catalyzed by RecA, a key step in homologous recombination. To elucidate the molecular… Continue reading RecA requires two molecules of Mg2+ ions for its optimal strand exchange activity in vitro
2018 / Scientific Reports
Hp1404, identified from the venom of the scorpion Heterometrus petersii, displays antimicrobial activity with cytotoxicity. Several synthetic peptides were designed based… Continue reading Mechanisms driving the antibacterial and antibiofilm properties of Hp1404 and its analogue peptides against multidrug-resistant Pseudomonas aeruginosa
2018 / Scientific Reports
An understanding of how conformational dynamics modulates function and catalysis of human monoacylglycerol lipase (hMGL), an important pharmaceutical target, can… Continue reading Effects of Distal Mutations on the Structure, Dynamics and Catalysis of Human Monoacylglycerol Lipase
2018 / The Journal of Chemical Physics
Internal friction is frequently found in protein dynamics. Its molecular origin however is difficult to conceptualize. Even unfolded and intrinsically… Continue reading Internal friction in an intrinsically disordered protein—Comparing Rouse-like models with experiments
2018 / Scientific Reports
Sperm chemotaxis toward a chemoattractant is very important for the success of fertilization. Calaxin, a member of the neuronal calcium… Continue reading Crystal structure of a Ca2+-dependent regulator of flagellar motility reveals the open-closed structural transition
2018 / Biochemistry
Protein misfolding due to mutation(s) and/or generation of unstable intermediate state(s) can be the cause of aberrant aggregations, leading to… Continue reading Disordered Nanostructure in Huntingtin Interacting Protein K Acts as a Stabilizing Switch To Prevent Protein Aggregation
2018 / The Journal of Organic Chemistry
The synthesis of hybrid urea-based foldamers containing isosteric guanidinium linkages at selected positions in the sequence is described. We used… Continue reading Postelongation Strategy for the Introduction of Guanidinium Units in the Main Chain of Helical Oligourea Foldamers
2018 / Journal of Natural Products
The cell extracts of two cultured freshwater Nostoc spp., UIC 10279 and UIC 10366, both from the suburbs of Chicago, showed antiproliferative… Continue reading Ribocyclophanes A–E, Glycosylated Cyclophanes with Antiproliferative Activity from Two Cultured Terrestrial Cyanobacteria
2018 / ACS Omega
Although the transition from B-DNA to the A-form is essential for many biological concerns, the properties of this transition have… Continue reading Comparison of the Binding Geometry of Free-Base and Hexacoordinated Cationic Porphyrins to A- and B-Form DNA
2018 / Marine Drugs
Three new compounds, tuberazines A–C (1–3), and eleven known compounds (4–14) were obtained from the ethanolic extract of Taiwanese zoanthid Palythoa… Continue reading Anti-Lymphangiogenesis Components from Zoanthid Palythoa tuberculosa
2018 / Scientific Reports
Hendra virus (HeV) is a paramyxovirus that causes lethal disease in humans, for which no vaccine or antiviral agent is… Continue reading Recognition by host nuclear transport proteins drives disorder-to-order transition in Hendra virus V
2018 / Materials Chemistry Frontiers
A Pt(II)phenylbipyridine complex 1, possessing phenylisoxazoles, long alkyl chains, and chiral alkyl chains, was synthesized. Complex 1 formed a stacked assembly in chloroform,… Continue reading A circularly polarized luminescent organogel based on a Pt(II) complex possessing phenylisoxazoles†
2018 / PNAS
The p63 gene encodes a master regulator of epidermal commitment, development, and differentiation. Heterozygous mutations in the C-terminal domain of the p63 gene can… Continue reading Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome
2018 / Materials Horizon
Protein-based materials provide an inherently biocompatible and sustainable platform for the generation of functional materials. Translating protein properties into protein… Continue reading Translation of protein charge and hydrophilicity to materials surface properties using thermal treatment in fluorous media
2018 / ACS Applied Materials & Interfaces
By incorporating hemin into G-quadruplex (G4) during cation-templated self-assembly between guanosine and KB(OH)4, we have constructed an artificial enzyme hydrogel… Continue reading Logic Catalytic Interconversion of G-Molecular Hydrogel
2018 / Scientific Reports
Dissolving microneedles (DMNs) are microscopic needles capable of delivering encapsulated compounds and releasing them into the skin in a minimally… Continue reading Exendin-4–encapsulated dissolving microneedle arrays for efficient treatment of type 2 diabetes
2018 / Scientific Reports
Vaccine development against Plasmodium vivax malaria lags behind that for Plasmodium falciparum. To narrow this gap, we administered recombinant antigens based on P. vivax circumsporozoite… Continue reading Prime-boost vaccination with recombinant protein and adenovirus-vector expressing Plasmodium vivaxcircumsporozoite protein (CSP) partially protects mice against Pb/Pv sporozoite challenge
2018 / Journal of Materials Chemistry C
The field of chiral nanoparticles has received a great deal of attention due to a wide range of potential applications… Continue reading Influence of CdSe and CdSe/CdS nanocrystals on the optical activity of chiral organic molecules
2018 / Bioengineering
Eptacog alfa (NovoSeven®) is a vitamin K-dependent recombinant Factor VIIa produced by genetic engineering from baby hamster kidney (BHK) cells… Continue reading Bioengineering of rFVIIa Biopharmaceutical and Structure Characterization for Biosimilarity Assessment
