Found 9617 Results / Page 289 of 481
2018 / Analyst
In aqueous solutions, an elongated, negatively charged DNA chain can quickly change its conformation into a compacted globule in the… Continue reading Investigation of compacted DNA structures induced by Na+ and K+monovalent cations using biological nanopores
2018 / Chirality
Polychlorinated biphenyls (PCBs) are harmful and persistent organic pollutants that have long been used in industrial manufacturing. Their persistence leads… Continue reading Enantioseparation and identification for the rationalization of the environmental impact of 4 polychlorinated biphenyls
2018 / Scientific Reports
In biological systems, there are many signal transduction cascades in which a chemical signal is transferred as a series of… Continue reading Response speed control of helicity inversion based on a “regulatory enzyme”-like strategy
2018 / Molecules
Sanggenon X, an unusual tri-O-bridged Diels-Alder adduct, was isolated from Cortex Mori Radicis. Its structure was established by spectroscopic analysis,… Continue reading A Tri-O-Bridged Diels-Alder Adduct from Cortex Mori Radicis
2018 / Advanced Functional Materials
Therapeutic antibodies (e.g., trastuzumab, TRA) against human epidermal growth factor receptor 2 (HER2)-positive breast cancers have shown benefits in controlling… Continue reading Two-Step Targeted Hybrid Nanoconstructs Increase Brain Penetration and Efficacy of the Therapeutic Antibody Trastuzumab against Brain Metastasis of HER2-Positive Breast Cancer
2018 / International Journal of Environmental Research and Public Health
The herbicide atrazine is widely used across the globe, which is a great concern. To investigate its potential toxicity in… Continue reading Biointeractions of Herbicide Atrazine with Human Serum Albumin: UV-Vis, Fluorescence and Circular Dichroism Approaches
2018 / RSC Advances
A rapid biosensor for the detection of cyromazine in milk is reported based on a fluorescence quenching result. When an… Continue reading A simple fluorescent assay for cyromazine detection in raw milk by using CYR-stabilized G-quadruplex formation
2018 / Scientific Reports
Sequence and structural homology suggests that MP-4 protein from Mucuna pruriens belongs to Kunitz-type protease inhibitor family. However, biochemical assays showed that… Continue reading Docking, thermodynamics and molecular dynamics (MD) studies of a non-canonical protease inhibitor, MP-4, from Mucuna pruriens
2018 / Organic & Biomolecular Chemistry
Molecular tools to stabilize the β-hairpin conformation are needed as β-hairpin peptides are useful molecules for pharmaceutical, biological and materials… Continue reading Conformational stabilization of a β-hairpin through a triazole–tryptophan interaction
2018 / International Journal of Molecular Sciences
A minimal model system for membrane fusion, comprising two complementary peptides dubbed “E” and “K” joined to a cholesterol anchor… Continue reading Peptide-Mediated Liposome Fusion: The Effect of Anchor Positioning
2018 / Marine Drugs
Seven new polyketides, named tanzawaic acids R–X (1–6, 11), along with seven known analogues (7–10 and 12–14), were isolated from Penicillium steckii HDN13-279. Their structures,… Continue reading Lipid-Lowering Polyketides from the Fungus Penicillium Steckii HDN13-279
2017 / Scientific Reports
Insulin-like peptide 3 (INSL3) is a member of the relaxin/insulin superfamily and is expressed in testicular Leydig cells. Essential for… Continue reading Insulin-like peptide 3 expressed in the silkworm possesses intrinsic disulfide bonds and full biological activity
2017 / Scientific Reports
Glutathione S‒transferases (GSTs) play an important role in the detoxification of xenobiotics. They catalyze the nucleophilic addition of glutathione (GSH)… Continue reading Comprehensive analysis of the catalytic and structural properties of a mu-class glutathione s-transferase from Fasciola gigantica
2017 / Biomacromolecules
Assembly of fibrillar peptide structures is dependent both upon their intrinsic propensities toward β-structure formation, as well as on structural… Continue reading Membrane Determinants Affect Fibrillation Processes of β-Sheet Charged Peptides
2018 / Metallomics
Cellular zinc (Zn(II)) is bound with proteins that are part of the proteomes of all domains of life. It is… Continue reading Interdependence of free zinc changes and protein complex assembly – insights into zinc signal regulation
2017 / Luminescence
The interaction between the food colorant canthaxanthin (CA) and human serum albumin (HSA) in aqueous solution was explored by using… Continue reading Exploration of interaction of canthaxanthin with human serum albumin by spectroscopic and molecular simulation methods
2017 / Molecules
A methanolic extract of Morella salicifolia bark was fractionated by various chromatographic techniques yielding six previously unknown cyclic diarylheptanoids, namely, 7-hydroxymyricanol 5-O-β-d-glucopyranoside… Continue reading Diarylheptanoid Glycosides of Morella salicifolia Bark
2017 / Nucleic Acids Research
The dynamics and mechanism of how site-specific DNA-bending proteins initially interrogate potential binding sites prior to recognition have remained elusive… Continue reading Two-step interrogation then recognition of DNA binding site by Integration Host Factor: an architectural DNA-bending protein
2018 / Biochemistry
Tondu domain-containing growth inhibitor (Tgi) is one of a growing number of multivalent PPxY proteins that regulate cell growth via… Continue reading Differential Binding Affinities and Allosteric Conformational Changes Underlie Interactions of Yorkie and a Multivalent PPxY Partner
2017 / PLoS ONE
The majority of life on Earth depends directly or indirectly on the sun as a source of energy. The initial… Continue reading Unique double concentric ring organization of light harvesting complexes in Gemmatimonas phototrophica
