Found 9617 Results / Page 290 of 481
2017 / Molecules
Serum albumin is exposed to numerous structural modifications which affect its stability and activity. Glycation is one of the processes… Continue reading In Vitro Investigation of the Interaction of Tolbutamide and Losartan with Human Serum Albumin in Hyperglycemia States
2018 / Biochemistry
Hydrophobins are multifunctional, highly surface active proteins produced in filamentous fungi and can be identified by eight conserved cysteine residues,… Continue reading A Structural and Functional Role for Disulfide Bonds in a Class II Hydrophobin
2018 / Nanoscale
Chirality has attracted extensive attention in many fields ranging from chemistry to life sciences. Carbon dots (CDs) with good biocompatibility… Continue reading Chiral evolution of carbon dots and the tuning of laccase activity
2017 / Macromolecular Bioscience
The use of sugar-functionalized polyplexes as a nonviral gene delivery vector with lower cytotoxicity than the well-known polymeric carrier branched… Continue reading Sweet Vector for Gene Delivery: the Sugar Decoration of Polyplexes Reduces Cytotoxicity with a Balanced Effect on Gene Expression
2018 / ChemBioChem
The multi-domain, catalytically self-sufficient cytochrome P450 BM-3 from Bacillus megaterium (P450BM3) constitutes a versatile enzyme for the oxyfunctionalization of organic… Continue reading Stabilization of the Reductase Domain in the Catalytically Self-Sufficient Cytochrome P450BM3 via Consensus-Guided Mutagenesis
2018 / ACS Nano
Understanding how molecules in self-assembled soft-matter nanostructures are organized is essential for improving the design of next-generation nanomaterials. Imaging these… Continue reading Bioinspired Silicification Reveals Structural Detail in Self-Assembled Peptide Cages
2017 / PLoS ONE
We have previously identified extensive glycation, bound fatty acids and increased quantities of protein aggregates in commercially available recombinant HSA… Continue reading Nanoparticle size and production efficiency are affected by the presence of fatty acids during albumin nanoparticle fabrication
2018 / ACS Sustainable Chemistry & Engineering
Gene expression controls and commands cellular functions of organisms and is considered to be the prime marker of human health.… Continue reading DNA-Templated Single Thermal Cycle Based Synthesis of Highly Luminescent Au Nanoclusters for Probing Gene Expression
2018 / Analytical Chemistry
The interface of nucleic acids and nanomaterials is among the most promising fields in recent years. Considerable efforts have been… Continue reading Quantification of Nucleic Acid Concentration in the Nanoparticle or Polymer Conjugates Using Circular Dichroism Spectroscopy
2017 / The Journal of Biological Chemistry
Aggregation of huntingtin protein arising from expanded polyglutamine (polyQ) sequences in the exon-1 region of mutant huntingtin plays a central… Continue reading The 17-residue-long N terminus in huntingtin controls step-wise aggregation in solution and on membranes via different mechanisms
2018 / Journal of Natural Products
A phytochemical investigation of an ethyl acetate extract of the aerial parts of Isodon pharicus led to the isolation of 21 new… Continue reading 7α,20-Epoxy-ent-kaurane Diterpenoids from the Aerial Parts of Isodon pharicus
2018 / European Journal of Medicinal Chemistry
((3RS,5SR)- and ((3RS,5RS)-2-(2-methoxybenzyl)-3-(1,10-phenanthrolin-2-yl)isoxazolidin-5-yl)methanol have been synthesized, according to 1,3-dipolar cycloaddition methodology, as DNA intercalating agents and evaluated for their anticancer activity against… Continue reading DNA intercalators based on (1,10-phenanthrolin-2-yl)isoxazolidin-5-yl core with better growth inhibition and selectivity than cisplatin upon head and neck squamous cells carcinoma
2018 / Soft Matter
A liquid crystal host–guest system composed of achiral organic molecules (host) and colored chiral metal complexes (guest) was fabricated to… Continue reading Left- and right-circularly polarized light-sensing based on colored and mechano-responsive chiral nematic liquid crystals
2017 / Journal of Peptide Science
Designing new antimicrobial peptides (AMPs) focuses heavily on the activity of the peptide and less on the elements that stabilize… Continue reading Biological consequences of improving the structural stability of hairpins that have antimicrobial activity
2017 / Scientific Reports
Web spiders synthesize silk fibres, nature’s toughest biomaterial, through the controlled assembly of fibroin proteins, so-called spidroins. The highly conserved… Continue reading Conservation of folding and association within a family of spidroin N-terminal domains
2017 / Journal of Biological Chemistry
The type I interferons (IFNs) are a family of cytokines with diverse biological activities including antiviral, antiproliferative, and immunoregulatory functions.… Continue reading Defining the distinct, intrinsic properties of the novel type I interferon, epsilon
2017 / Biochemistry
The unique occurrence of G-quadruplexes in the AT-rich genome of human malaria parasite Plasmodium falciparum provides hints about their critical roles in… Continue reading Investigating Pharmacological Targeting of G-Quadruplexes in the Human Malaria Parasite
2017 / International Journal of Food Science & Technology
In this study, the effects of high-pressure homogenisation (HPH) treatment on structural and functional properties of mussel protein isolate (MPI)… Continue reading Effects of high-pressure homogenisation on structural and functional properties of mussel (Mytilus edulis) protein isolate
2017 / Advanced Materials Interfaces
The selective interaction is systematically explored between the surfactants (sodium deoxycholate (DOC), sodium dodecyl sulfate (SDS), and sodium cholate (SC))… Continue reading Detecting and Tuning the Interactions between Surfactants and Carbon Nanotubes for Their High-Efficiency Structure Separation
2018 / Chemical Research in Toxicology
Aromatic chemical carcinogens can undergo enzymatic transformations to produce a range of electrophilic species that attach covalently to the C8-site… Continue reading Conformational Preference and Fluorescence Response of a C-Linked C8-Biphenyl-Guanine Lesion in the NarI Mutational Hotspot: Evidence for Enhanced Syn Adduct Formation
