Found 9617 Results / Page 298 of 481
2017 / Biochemistry
Coiled coils are a robust motif for exploring amino acid interactions, generating unique supramolecular structures, and expanding the functional properties… Continue reading The Phe-Ile Zipper: A Specific Interaction Motif Drives Antiparallel Coiled-Coil Hexamer Formation
2017 / RSC Advances
Fibrillogenesis of human islet amyloid polypeptide (hIAPP) is a pathological hallmark of type II diabetes mellitus (T2DM), and the inhibition… Continue reading Brazilin inhibits fibrillogenesis of human islet amyloid polypeptide, disassembles mature fibrils, and alleviates cytotoxicity
2017 / The Journal of Physical Chemistry B
It has been difficult to quantify the degree of side-chain conformational heterogeneity in the native (N) state ensemble of proteins… Continue reading An Alternatively Packed Dry Molten Globule-like Intermediate in the Native State Ensemble of a Multidomain Protein
2017 / Biomacromolecules
Hydrogen-bonded β-sheets are the most commonly explored building motifs for creating peptide-based filamentous nanostructures; however, most bioactive epitopes must assume… Continue reading Conformation Preservation of α-Helical Peptides within Supramolecular Filamentous Assemblies
2017 / Dalton Transactions
N-Terminally free but C-terminally amidated peptides Pen-SSACS-NH2 and CSSA-Pen-S-NH2 containing L-penicillamine (Pen) in sequence have been synthesized and their nickel(II), zinc(II) and cadmium(II)… Continue reading The influence of penicillamine/cysteine mutation on the metal complexes of peptides
2017 / ACS Chemical Biology
Backbone circularization of protein is a powerful method to improve its structural stability. In this paper, we presumed that a… Continue reading Backbone Circularization Coupled with Optimization of Connecting Segment in Effectively Improving the Stability of Granulocyte-Colony Stimulating Factor
2017 / Toxins
Nine publically available biosafety protocols for safely handling conotoxin peptides were tested to evaluate their decontamination efficacy. Circular dichroism (CD)… Continue reading α-Conotoxin Decontamination Protocol Evaluation: What Works and What Doesn’t
2017 / Organic & Biomolecular Chemistry
We designed and synthesized a novel artificial 2′-O,4′-C-methylene bridged nucleic acid (2′,4′-BNA/LNA) with a phenoxazine nucleobase and named this compound… Continue reading Synthesis and thermal stabilities of oligonucleotides containing 2′-O,4′-C-methylene bridged nucleic acid with a phenoxazine base
2017 / Journal of Molecular Biology
Alzheimer’s disease is characterized by the self-assembly of tau and amyloid βproteins into oligomers and fibrils. Tau protein assembles into paired helical filaments (PHFs) that… Continue reading Alzheimer’s Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking
2017 / Applied Organometallic Chemistry
Mononuclear and dinuclear copper(II) complexes with thiophenecarboxylic acid, [Cu(3-TCA)2(2,2′-bpy)] (1), [Cu(3-Me-2-TCA)2(H2O)(2,2′-bpy)] (2), [Cu(5-Me-2-TCA)2(H2O)(2,2′-bpy)] (3) and [Cu2(2,5-TDCA)(DMF)2(H2O)2(2,2′-bpy)2](ClO4)2 (4) (where 3-TCA = 3-thiophenecarboxylic acid; 3-Me-2-TCA = 3-methyl-2-thiophenecarboxylic… Continue reading Synthesis and structural and DNA binding studies of mono- and dinuclear copper(II) complexes constructed with ─O and ─N donor ligands: Potential anti-skin cancer drugs
2017 / ACS Biomaterials Science & Engineering
We herein report that hydrogels can be prepared from guanosine and boronic acids in the presence of K+ and Pb2+ ions. These… Continue reading Supramolecular Hydrogel Inspired from DNA Structures Mimics Peroxidase Activity
2017 / ACS Omega
The classic G-quadruplex motif consists of a continuous array of 3–4 guanine residues with an intermittent loop size of 1–7… Continue reading Mutagenesis Reveals an Unusual Combination of Guanines in RNA G-Quadruplex Formation
2017 / The Journal of Physical Chemistry C
The process of amyloid-β (Aβ) amyloid formation is pathologically linked to Alzheimer’s disease (AD). The identification of Aβ amyloids and… Continue reading Gold Nanoparticles as a Probe for Amyloid-β Oligomer and Amyloid Formation
2017 / Protein Science
Monoclonal antibodies of the immunoglobulin G (IgG) type have become mainstream therapeutics for the treatment of many life-threatening diseases. For… Continue reading Analysis of IgG kinetic stability by differential scanning calorimetry, probe fluorescence and light scattering
2017 / RSC Advances
The rapid increase of antimicrobial resistance against conventional antibiotics has resulted in a significant focus on the use of peptides… Continue reading Drug and dye binding induced folding of the intrinsically disordered antimicrobial peptide CM15
2017 / Journal of Biological Inorganic Chemistry
Monothiol glutaredoxins (Grx) serve as intermediate cluster carriers in iron-sulfur cluster trafficking. The [2Fe–2S]-bound holo forms of Grx proteins display… Continue reading Role of protein-glutathione contacts in defining glutaredoxin-3 [2Fe–2S] cluster chirality, ligand exchange and transfer chemistry
2017 / Analytical Chemistry
Despite a significant surge in the number of investigations into chirality at the nanoscale, especially thiolated chiral molecules capping gold… Continue reading Optically Active Ultrafine Au–Ag Alloy Nanoparticles Used for Colorimetric Chiral Recognition and Circular Dichroism Sensing of Enantiomers
2018 / International Journal of Biological Macromolecules
Present study allows us a better understanding of the interaction of nitidine, a benzophenanthridine alkaloid with single stranded polyriboadenylic acid… Continue reading Self-structure assembly in single stranded polyriboadenylic acid by benzophenanthridine alkaloid: Spectroscopic and calorimetric exploration
2017 / Molecules
Rational mutation of proteins based on their structural and dynamic characteristics is a useful strategy for amplifying specific fluctuations in… Continue reading Interactions Controlling the Slow Dynamic Conformational Motions of Ubiquitin
2018 / International Journal of Biological Macromolecules
Heat shock proteins of 90 kDa (Hsp90) are molecular chaperones essential for protein homeostasis. Besides chaperone activity, Hsp90 exhibits other cellular… Continue reading Interaction of heat shock protein 90 B1 (Hsp90B1) with liposome reveals its potential role in protection the integrity of lipid membranes
