KnowledgeBase Articles Archive

Exploring the binding of two potent anticancer drugs bosutinib and imatinib mesylate with bovine serum albumin: spectroscopic and molecular dynamic simulation studies

2017 / Analytical and Bioanalytical Chemistry

Bosutinib (BST) and imatinib mesylate (IMT) are tyrosine kinase inhibitors (TKIs). In view of the importance of these inhibitors in… Continue reading Exploring the binding of two potent anticancer drugs bosutinib and imatinib mesylate with bovine serum albumin: spectroscopic and molecular dynamic simulation studies

Diagnostic Absolute Configuration Determination of Tetraphenylethene Core-Based Chiral Aggregation-Induced Emission Compounds: Particular Fingerprint Bands in Comprehensive Chiroptical Spectroscopy

2017 / The Journal of Physical Chemistry C

Tetraphenylethylene (TPE) and its derivatives are the typical aggregation-induced emission (AIE) compounds with helical chirality, and they have enormous applications… Continue reading Diagnostic Absolute Configuration Determination of Tetraphenylethene Core-Based Chiral Aggregation-Induced Emission Compounds: Particular Fingerprint Bands in Comprehensive Chiroptical Spectroscopy

Cyclic Hexapeptide Dimers, Antatollamides A and B, from the Ascidian Didemnum molle. A Tryptophan-Derived Auxiliary for l- and d-Amino Acid Assignments

2017 / The Journal of Organic Chemistry

Two dimerized cyclic hexapeptides, antatollamides A (1) and B (2), were isolated from the colonial ascidian Didemnum molle collected in Pohnpei. The… Continue reading Cyclic Hexapeptide Dimers, Antatollamides A and B, from the Ascidian Didemnum molle. A Tryptophan-Derived Auxiliary for l- and d-Amino Acid Assignments

A multi-functional guanine derivative for studying the DNA G-quadruplex structure

2017 / Analyst

In the present study, we developed a multi-functional guanine derivative, 8FG, as a G-quadruplex stabilizer, a fluorescent probe for the detection… Continue reading A multi-functional guanine derivative for studying the DNA G-quadruplex structure

Dynamic control over catalytic function using responsive bisthiourea catalysts

2017 / Organic & Biomolecular Chemistry

Two novel bisthiourea molecular motor-based catalysts were designed and their dynamic control of activity and stereoselectivity in the Henry reaction… Continue reading Dynamic control over catalytic function using responsive bisthiourea catalysts

Structural and Functional Analyses of Periplasmic 5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase from Aeromonas hydrophila

2017 / Biochemistry

The Gram-negative, rod-shaped bacterium Aeromonas hydrophila has two multifunctional 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) enzymes, MtaN-1 and MtaN-2, that differ from those in other… Continue reading Structural and Functional Analyses of Periplasmic 5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase from Aeromonas hydrophila

Heavy metal detoxification by recombinant ferritin fromApostichopus japonicus

2017 / RSC Advances

Ferritin is a bionanomaterial that is widely applied in magnetic resonance imaging, drug delivery systems, biocompatible fluorescence, neutron-capture therapy and… Continue reading Heavy metal detoxification by recombinant ferritin fromApostichopus japonicus

Endocannabinoid Interaction with Human FABP1: Impact of the T94A Variant

2017 / Biochemistry

Using recombinant human wild-type fatty acid binding protein 1 (WT FABP1 T94T) and a variant (FABP1 T94A) protein, fluorescence binding… Continue reading Endocannabinoid Interaction with Human FABP1: Impact of the T94A Variant

Self-Assembly of Thermoresponsive Recombinant Silk-Elastinlike Nanogels

2017 / Macromolecular Bioscience

Recombinant silk-elastinlike protein polymers (SELPs) combine the biocompatibility and thermoresponsiveness of human tropoelastin with the strength of silk. Direct control… Continue reading Self-Assembly of Thermoresponsive Recombinant Silk-Elastinlike Nanogels

Sustained release of multicomponent platelet-rich plasma proteins from hydrolytically degradable PEG hydrogels

2017 / Journal of Biomedical Materials Research Part A

latelet-rich plasma (PRP), an autologous blood derived product is a concentrated mix of multiple growth factors and cytokines. Direct injections… Continue reading Sustained release of multicomponent platelet-rich plasma proteins from hydrolytically degradable PEG hydrogels

Eliminating glutaraldehyde from crosslinked collagen films using supercritical CO2

2018 / Journal of Biomedical Materials Research Part A

Collagen has received considerable attention as a biomaterial for tissue engineering because of its low immunogenicity, controllable biodegradation, and ability… Continue reading Eliminating glutaraldehyde from crosslinked collagen films using supercritical CO2

Role of Electrostatics in Protein–RNA Binding: The Global vs the Local Energy Landscape

2017 / The Journal of Physical Chemistry B

U1A protein–stem loop 2 RNA association is a basic step in the assembly of the spliceosomal U1 small nuclear ribonucleoprotein.… Continue reading Role of Electrostatics in Protein–RNA Binding: The Global vs the Local Energy Landscape

Chiral PEDOT-Based Enantioselective Electrode Modification Material for Chiral Electrochemical Sensing: Mechanism and Model of Chiral Recognition

2017 / Analytical Chemistry

The development of electrochemical methods for enantioselective recognition is a focus of research in pharmaceuticals and biotechnology. In this study,… Continue reading Chiral PEDOT-Based Enantioselective Electrode Modification Material for Chiral Electrochemical Sensing: Mechanism and Model of Chiral Recognition

Fluorescence quenching, structural and unfolding studies of a purified cysteine protease, ZCPG from Zingiber montanum rhizome

2018 / International Journal of Biological Macromolecules

A first attempt was made to study the fluorescence quenching, structure and unfolding nature of the purified Zingiber montanum (J.Koenig) Link ex… Continue reading Fluorescence quenching, structural and unfolding studies of a purified cysteine protease, ZCPG from Zingiber montanum rhizome

Identification of drivers for the metamorphic transition of HIV-1 reverse transcriptase

2017 / Biochemical Journal

Recent structural characterizations of the p51 and p66 monomers has established an important starting point for understanding the maturation pathway… Continue reading Identification of drivers for the metamorphic transition of HIV-1 reverse transcriptase

Annealing-Induced Circular Dichroism Enhancement in Luminescent Conjugated Polymers with an Intramolecular Stack Structure

2017 / Macromolecules

Two poly(diphenylacetylene) derivatives containing identical chiral pinanyl groups on the para- and meta-positions of the side phenyl ring were prepared, and their… Continue reading Annealing-Induced Circular Dichroism Enhancement in Luminescent Conjugated Polymers with an Intramolecular Stack Structure

Mueller Matrix Fluorescence Spectroscopy for Probing Self-Assembled Peptide-Based Hybrid Supramolecular Structure and Orientation

2017 / The Journal of Physical Chemistry C

Probing the assembly mechanism, orientation, shape, and structure function relationship of hybrid supramolecular materials is an outstanding challenge. In this… Continue reading Mueller Matrix Fluorescence Spectroscopy for Probing Self-Assembled Peptide-Based Hybrid Supramolecular Structure and Orientation

Enhancing Enzyme Activity and Immobilization in Nanostructured Inorganic–Enzyme Complexes

2017 / Langmuir

Understanding the chemical and physical interactions at the interface of protein surfaces and inorganic crystals has important implications in the… Continue reading Enhancing Enzyme Activity and Immobilization in Nanostructured Inorganic–Enzyme Complexes

Self-assembled chiral nanostructures of amphiphilic peptide: from single molecule to aggregate

2017 / Journal of Peptide Science

We report interesting hierarchical self-assembled architectures from a designed amphiphilic peptide. The bisignate cotton effects in circular dichroism spectra show… Continue reading Self-assembled chiral nanostructures of amphiphilic peptide: from single molecule to aggregate

DNAzyme Based Amplified Biosensor on Ultrasensitive Fluorescence Detection of Pb (II) Ions from Aqueous System

2017 / Journal of Fluorescence

A label -free DNAzyme amplified biosensor is found to be highly selective and sensitive towards fluorescent detection of Pb2+ ions… Continue reading DNAzyme Based Amplified Biosensor on Ultrasensitive Fluorescence Detection of Pb (II) Ions from Aqueous System

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