Found 9617 Results / Page 301 of 481
2017 / New Journal of Chemistry
Selenium (Se) nanoparticles (NPs) have attracted significant interest in biological and biomedical applications due to their therapeutic efficacy. For any in… Continue reading Elucidating the interaction of L-cysteine-capped selenium nanoparticles and human serum albumin: spectroscopic and thermodynamic analysis
2017 / Chemistry: A European Journal
Peptides containing aromatic residues are known to exhibit spontaneous phenomena of supramolecular organization into ordered nanostructures (NSs). In this work… Continue reading Structural Characterization of PEGylated Hexaphenylalanine Nanostructures Exhibiting Green Photoluminescence Emission
2017 / ACS Infectious Disease
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a highly successful human pathogen and has infected approximately one-third of… Continue reading Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosisIs Controlled by a Redox-Sensitive Thiol Switch
2018 / AAPS PharmSciTech
Optical coherence tomography freeze-drying microscopy (OCT-FDM) is a novel technique that allows the three-dimensional imaging of a drug product during… Continue reading Application of Optical Coherence Tomography Freeze-Drying Microscopy for Designing Lyophilization Process and Its Impact on Process Efficiency and Product Quality
2018 / International Journal of Biological Macromolecules
Hypochlorous acid (HOCl) is generated by activated phagocytes at the site of inflammation. Exposure of DNA to HOCl results in base and nucleotide modifications… Continue reading Hypochlorous acid induced structural and conformational modifications in human DNA: A multi-spectroscopic study
2017 / Journal of Peptide Science
Linear cationic α-helical antimicrobial peptides are promising chemotherapeutics. Most of them act by different mechanisms, making it difficult to microorganisms… Continue reading Antimicrobial activity of leucine-substituted decoralin analogs with lower hemolytic activity
2017 / ACS Biomaterials Science & Engineering
Self-assembling fibrous supramolecular assemblies with sophisticated hierarchical structures at the mesoscale are of interest from both fundamental and applied engineering.… Continue reading Self-Assembling Silk-Based Nanofibers with Hierarchical Structures
2017 / Chirality
3-Ethyl-3-phenylpyrrolidin-2-one (EPP) is an experimental anticonvulsant based on the newly proposed α-substituted amide group pharmacophore. These compounds show robust activity in… Continue reading Racemic and enantiopure forms of 3-ethyl-3-phenylpyrrolidin-2-one adopt very different crystal structures
2017 / Macromolecular Bioscience
Recombinantly produced spider silk proteins have high potential for bioengineering and various biomedical applications because of their biocompatibility, biodegradability, and… Continue reading Characterization of Hydrogels Made of a Novel Spider Silk Protein eMaSp1s and Evaluation for 3D Printing
2017 / Pharmaceutical Research
There are many important diseases whose treatment could be improved by delivering a therapeutic protein to the colon, for example,… Continue reading A Multiparticulate Delivery System for Potential Colonic Targeting Using Bovine Serum Albumin as a Model Protein
2017 / Journal of Basic Microbiology
Functional screening of metagenomic libraries is an important tool for the discovery of new molecules. The metabolic diversity of microorganisms… Continue reading Metagenomic alkaline protease from mangrove sediment
2017 / Langmuir
Controlling the hierarchical organization of self-assembling peptide amphiphiles into supramolecular nanostructures opens up the possibility of developing biocompatible functional supramolecular… Continue reading Hierarchical Self-Assembly of Histidine-Functionalized Peptide Amphiphiles into Supramolecular Chiral Nanostructures
2017 / Langmuir
Localized self-assembly allowing both spatial and temporal control over the assembly process is essential in many biological systems. This can… Continue reading Control of Surface-Localized, Enzyme-Assisted Self-Assembly of Peptides through Catalyzed Oligomerization
2017 / Chemistry: A European Journal
When used as inhibitors of gene expression in vivo, oligonucleotides require modification of their structures to boost their binding affinity for… Continue reading Towards Improved Oligonucleotide Therapeutics Through Faster Target Binding Kinetics
2017 / New Journal of Chemistry
An in situ reaction of CuCl2·2H2O, o-phenylenediamine, thiophene-2-carbaldehyde and sodium azide in methanol afforded complex 1a. Originally, it was expected to form a binuclear… Continue reading Unpredicted formation of copper(II) complexes containing 2-thiophen-2-yl-1-thiophen-2-ylmethyl-1H-benzoimidazole and their most promising in vitro cytotoxicity in MCF-7 and HeLa cell lines over cisplatin
2017 / Scientific Reports
An exonucleolytic digestion-assisted exponential rolling circle amplification (RCA) strategy was developed for sensitive and sequence-specific detection of target DNA embedded… Continue reading Dual functional Phi29 DNA polymerase-triggered exponential rolling circle amplification for sequence-specific detection of target DNA embedded in long-stranded genomic DNA
2017 / European Biophysics Journal
We studied the conformational changes of the fatty acid-binding protein ReP1-NCXSQ in the interface of anionic lipid membranes. ReP1-NCXSQ is… Continue reading Conformational changes, from β-strand to α-helix, of the fatty acid-binding protein ReP1-NCXSQ in anionic lipid membranes: dependence with the vesicle curvature
2017 / Amino Acids
Increasing drug resistance of common pathogens urgently needs discovery of new effective molecules. Antimicrobial peptides are believed to be one… Continue reading Retro analog concept: comparative study on physico-chemical and biological properties of selected antimicrobial peptides
2017 / Chemistry: A European Journal
Physicochemical methods have been used to investigate interactions occurring in solution between the dicarbene gold(I) complex [Au(9-methylcaffein-8-ylidene)2]BF4 (AuNHC) and a human… Continue reading [Au(9-methylcaffein-8-ylidene)2]+/DNA Tel23 System: Solution, Computational, and Biological Studies
2017 / ACS Chemical Neuroscience
The characteristic cross-β-sheet-rich amyloid fibril formation by intrinsically disordered α-synuclein proteins is one of the pathological hallmarks of Parkinson’s disease.… Continue reading Perturbation in Long-Range Contacts Modulates the Kinetics of Amyloid Formation in α-Synuclein Familial Mutants
