Found 9617 Results / Page 302 of 481
2017 / Nanomaterials
The chiroptical properties of amorphous chiral polymers functionalized with conjugated trans-azoaromatic chromophore linked to the backbone through a chiral cyclic pyrrolidine… Continue reading Chirality on Amorphous High-Tg Polymeric Nanofilms: Optical Activity Amplification by Thermal Annealing
2017 / JACS
The hedgehog (Hh) signaling pathway plays a central role during embryonic development, and its aberrant activation has been implicated in… Continue reading Design and Evolution of a Macrocyclic Peptide Inhibitor of the Sonic Hedgehog/Patched Interaction
2017 / PLoS ONE
Despite substantial research on cancer therapeutics, systemic toxicity and drug-resistance limits the clinical application of many drugs like cisplatin. Therefore,… Continue reading Synthesis of novel coumarin nucleus-based DPA drug-like molecular entity: In vitro DNA/Cu(II) binding, DNA cleavage and pro-oxidant mechanism for anticancer action
2017 / Industrial & Engineering Chemistry Research
The application of magnetic field is being tested as a way to intensify enzymatic processes. However, studies on the magnetic… Continue reading Characterization of the Performance and Catalytic Activity of Lysozyme from Chicken Egg Submitted to Permanent Magnetic Field
2017 / Biomolecules
The cytoplasmic polyadenylation element binding protein (CPEB) homologue Orb2 is a functional amyloid that plays a key regulatory role for… Continue reading Metal Binding Properties of the N-Terminus of the Functional Amyloid Orb2
2017 / Cell Biochemistry and Biophysics
Cruzain, a cysteine protease in the cathepsin family, is pivotal to the life-cycle of Trypanosoma cruzi, the etiological agent in Chagas… Continue reading Identification of Structure-Stabilizing Interactions in Enzymes: A Novel Mechanism to Impact Enzyme Activity
2017 / Advanced Functional Materials
Poor tumor selectivity and short life span of reactive oxygen species (ROS) are two major challenges in photodynamic therapy (PDT).… Continue reading A Self-Transformable pH-Driven Membrane-Anchoring Photosensitizer for Effective Photodynamic Therapy to Inhibit Tumor Growth and Metastasis
2017 / Chirality
The twisted structure of ditellurides, in a similar way as in other dichalcogenes, leads to different absorption of circularly polarized… Continue reading Chiral dialkyl ditellurides: Conformation of chiral chromophore by circular dichroism and DFT calculation
2017 / Fitoterapia
Five picrotoxane sesquiterpenoids belonging to the unusual dendrobine-type (1 and 4) and the picrotoxinin-type (2, 3, and 5) were isolated from the stems of Dendrobium… Continue reading Picrotoxane sesquiterpenoids from the stems of Dendrobium nobile and their absolute configurations and angiogenesis effect
2017 / Pharmaceutical Chemistry Journal
General information about the synthesis and properties of glatiramer acetate (GA) drug substance and the principles and methods for verifying… Continue reading Axoglatiran® FS: Generic of Copaxone® Preparation Based on Glatiramer Acetate
2017 / PLoS ONE
Cytosine deamination induced by stresses or enzymatic catalysis converts deoxycytidine into deoxyuridine, thereby introducing a G to A mutation after… Continue reading Crystal structure of mimivirus uracil-DNA glycosylase
2017 / Macromolecular Rapid Communications
Here, the fabrication of unimolecular micelles functionalized with helical polymeric chains as a chiral nucleating agent in enantioselective crystallization is… Continue reading Synthesis of Unimolecular Micelles with Incorporated Hyperbranched Boltorn H30 Polyester modified with Hyperbranched Helical Poly(phenyl isocyanide) Chains and their Enantioselective Crystallization Performance
2017 / Biopolymers
In the past two decades, keratin biomaterials have shown impressive results as scaffolds for tissue engineering, wound healing, and nerve… Continue reading Homo- and heteropolymer self-assembly of recombinant trichocytic keratins
2017 / Soft Matter
Helical polymers are widely found in nature and synthetic functional materials. Although a number of elaborate strategies have been developed… Continue reading Fabrication of chiroptically switchable films via co-gelation of a small chiral gelator with an achiral azobenzene-containing polymer
2017 / Journal of Biological Chemistry
The role of the peptide hormone calcitonin in skeletal protection has led to its use as a therapeutic for osteoporosis.… Continue reading Growth-incompetent monomers of human calcitonin lead to a non-canonical direct relationship between peptide concentration and lag time
2017 / The Journal of Physical Chemistry B
Many biologically important processes involve a subtle interplay between Columbic and hydrophobic interactions among molecular groups with water. A comprehensive… Continue reading Decisive Role of Hydrophobicity on the Effect of Alkylammonium Chlorides on Protein Stability: A Terahertz Spectroscopic Finding
2017 / Langmuir
Femtosecond (fs)-laser-induced crystallization as a novel crystallization technique was proposed for the first time by our group, where the crystallization… Continue reading Femtosecond-Laser-Enhanced Amyloid Fibril Formation of Insulin
2017 / Journal of Biological Chemistry
Dr fimbriae are homopolymeric adhesive organelles of uropathogenic Escherichia coli composed of DraE subunits, responsible for the attachment to host… Continue reading Role of the disulfide bond in stabilizing and folding of the fimbrial protein DraE from uropathogenic Escherichia coli
2017 / RSC Advances
G-Quadruplex DNA (G4–DNA) is one of the most important non-canonical nucleic acid structures. G4–DNA forming sequences are present in different… Continue reading Exploring the preferential interaction of quercetin with VEGF promoter G-quadruplex DNA and construction of a pH-dependent DNA-based logic gate
2017 / Journal of Inorganic Biochemistry
The lectin DLasiL was isolated from seeds of the Dioclea lasiocarpa collected from the northeast coast of Brazil and characterized for the first time… Continue reading The potent anti-cancer activity of Dioclea lasiocarpa lectin
