KnowledgeBase Articles Archive

Isolation and Antibiotic Screening of Fungi from a Hydrothermal Vent Site and Characterization of Secondary Metabolites from a Penicillium Isolate

2017 / Marine Biology

Five new compounds were isolated from Penicillium sp. Y-5-2 including an austin derivative 4, four isocoumarins 9, 11, 12, and 13, together with two known isocoumarins 8 and 10, and… Continue reading Isolation and Antibiotic Screening of Fungi from a Hydrothermal Vent Site and Characterization of Secondary Metabolites from a Penicillium Isolate

Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH

2017 / Polymers

Polypeptide polymers can adopt natural protein secondary structures such as α-helices or β-sheets, and this unique feature is at the… Continue reading Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH

Stabilization of protein structure through π–π interaction in the second coordination sphere of pseudoazurin

2017 / Protein Science

Noncovalent, weak interactions in the second coordination sphere of the copper active site of Pseudoazurin (PAz) from Achromobacter cycloclastes were examined using… Continue reading Stabilization of protein structure through π–π interaction in the second coordination sphere of pseudoazurin

Characterization of the molecular chaperone ClpB from the pathogenic spirochaete Leptospira interrogans

2017 / PLoS ONE

Leptospira interrogans is a spirochaete responsible for leptospirosis in mammals. The molecular mechanisms of the Leptospira virulence remain mostly unknown. Recently, it has… Continue reading Characterization of the molecular chaperone ClpB from the pathogenic spirochaete Leptospira interrogans

Short Peptides Directing 1D Helical Arrays of Polyoxometalates with Controllable Pitches

2017 / Chemistry: A European Journal

A series of cationic peptides with alternating hydrophilic and hydrophobic residues were elaborately designed and synthesized. These kinds of short… Continue reading Short Peptides Directing 1D Helical Arrays of Polyoxometalates with Controllable Pitches

Naphthalene amine support for G-quadruplex isolation

2017 / Analyst

G-quadruplex (G4) is involved in many biological processes, such as telomere function, gene expression and DNA replication. The selective isolation… Continue reading Naphthalene amine support for G-quadruplex isolation

Otoferlin is a multivalent calcium-sensitive scaffold linking SNAREs and calcium channels

2017 / PNAS

Sensory hair cells rely on otoferlin as the calcium sensor for exocytosis and encoding of sound preferentially over the neuronal… Continue reading Otoferlin is a multivalent calcium-sensitive scaffold linking SNAREs and calcium channels

Functional characterization of hormone sensitive-like lipase from Bacillus halodurans: synthesis and recovery of pNP-laurate with high yields

2017 / Extremophiles

The HSL-like lipase encoding gene (Blip) from the polyextremophile Bacillus halodurans C-125 has been heterologously expressed in E.coli BL21(DE3). The enzyme is a monomer… Continue reading Functional characterization of hormone sensitive-like lipase from Bacillus halodurans: synthesis and recovery of pNP-laurate with high yields

Alkaloids from the stems of Clausena lansium and their neuroprotective activity

2017 / RSC Advances

ight new alkaloids, including three pairs of enantiomers (+)-(2′S,3′R)-clauselansine A (1a) and (−)-(2′R,3′S)-clauselansine A (1b); (+)-(2′S,3′R)-clauselansine B (2a) and (−)-(2′R,3′S)-clauselansine… Continue reading Alkaloids from the stems of Clausena lansium and their neuroprotective activity

Deciphering the mechanism of interaction of edifenphos with calf thymus DNA

2018 / Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Edifenphos is an important organophosphate pesticide with many antifungal and anti-insecticidal properties but it may cause potential hazards to human… Continue reading Deciphering the mechanism of interaction of edifenphos with calf thymus DNA

A New N-methoxypyridone from the Co-Cultivation of Hawaiian Endophytic Fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062

2017 / Molecules

A new N-methoxypyridone analog (1), together with four known compounds, was isolated from the co-culture of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum… Continue reading A New N-methoxypyridone from the Co-Cultivation of Hawaiian Endophytic Fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062

Biosynthesis of Single Thioether c-Type Cytochromes Provides Insight into Mechanisms Intrinsic to Holocytochrome c Synthase (HCCS)

2017 / Biochemistry

C-type cytochromes (cyts c) are generally characterized by the presence of two thioether attachments between heme and two cysteine residues… Continue reading Biosynthesis of Single Thioether c-Type Cytochromes Provides Insight into Mechanisms Intrinsic to Holocytochrome c Synthase (HCCS)

Fragile X mental retardation protein recognizes a G quadruplex structure within the survival motor neuron domain containing 1 mRNA 5′-UTR

2017 / Molecular BioSystems

G quadruplex structures have been predicted by bioinformatics to form in the 5′- and 3′-untranslated regions (UTRs) of several thousand… Continue reading Fragile X mental retardation protein recognizes a G quadruplex structure within the survival motor neuron domain containing 1 mRNA 5′-UTR

Transition from disordered aggregates to ordered lattices: kinetic control of the assembly of a computationally designed peptide

2017 / Organic & Biomolecular Chemistry

Natural biomolecular self-assembly typically occurs under a narrow range of solution conditions, and the design of sequences that can form… Continue reading Transition from disordered aggregates to ordered lattices: kinetic control of the assembly of a computationally designed peptide

Identification of human flap endonuclease 1 (FEN1) inhibitors using a machine learning based consensus virtual screening

2017 / Molecular BioSystems

Human Flap endonuclease1 (FEN1) is an enzyme that is indispensable for DNA replication and repair processes and inhibition of its… Continue reading Identification of human flap endonuclease 1 (FEN1) inhibitors using a machine learning based consensus virtual screening

Characterization and Evaluation of Key Sites in the Peptide Inhibitor of TAB1/p38α Interaction

2017 / International Journal of Peptide Research and Therapeutics

A combination of computation techniques and peptide mutants have been used to determine the binding site and amino acid residues… Continue reading Characterization and Evaluation of Key Sites in the Peptide Inhibitor of TAB1/p38α Interaction

The Sulfur-Linked Analogue of O-GlcNAc (S-GlcNAc) Is an Enzymatically Stable and Reasonable Structural Surrogate for O-GlcNAc at the Peptide and Protein Levels

2017 / Biochemistry

Synthetic proteins bearing site-specific posttranslational modifications have revolutionized our understanding of their biological functions in vitro and in vivo. One such modification, O-GlcNAcylation,… Continue reading The Sulfur-Linked Analogue of O-GlcNAc (S-GlcNAc) Is an Enzymatically Stable and Reasonable Structural Surrogate for O-GlcNAc at the Peptide and Protein Levels

Tuning the solution organization of cationic polymers through interactions with bovine serum albumin

2017 / Physical Chemistry Chemical Physics

The interactions of bovine serum albumin (BSA) with aggregates of cationic polymers, i.e. quaternized poly(chloromethyl styrene) chains (QIm-PCMS), in aqueous solutions are… Continue reading Tuning the solution organization of cationic polymers through interactions with bovine serum albumin

Poly(trehalose) Nanoparticles Prevent Amyloid Aggregation and Suppress Polyglutamine Aggregation in a Huntington’s Disease Model Mouse

2017 / ACS Applied Materials & Interfaces

Prevention and therapeutic strategies for various neurodegenerative diseases focus on inhibiting protein fibrillation, clearing aggregated protein plaques from the brain,… Continue reading Poly(trehalose) Nanoparticles Prevent Amyloid Aggregation and Suppress Polyglutamine Aggregation in a Huntington’s Disease Model Mouse

Formation of supermolecular chiral gels from L-aspartic acid-based perylenebisimides and benzene dicarboxylic acids

2017 / New Journal of Chemistry

Herein, supramolecular gels from L-aspartic acid-based perylenebisimides (APBI) and various isomeric benzene dicarboxylic acids (o-phthalic acid, OPA; isophthalic acid, IPA and… Continue reading Formation of supermolecular chiral gels from L-aspartic acid-based perylenebisimides and benzene dicarboxylic acids

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