Found 9617 Results / Page 310 of 481
2017 / Nature Chemical Biology
Miniproteins simplify the protein-folding problem, allowing the dissection of forces that stabilize protein structures. Here we describe PPa-Tyr, a designed… Continue reading Engineering protein stability with atomic precision in a monomeric miniprotein
2017 / Dyes and Pigments
Searching for specific G-quadruplex DNA probes is important for study of the function of G-rich gene sequence, as well as… Continue reading G-quadruplex DNA fluorescence sensing by a bis-amine-substituted styrylquinolinium dye
2017 / Phytochemistry
The traditionally used Central American medicinal plant Pluchea odorata, known as an anti-inflammatory and cancer cell growth-inhibiting remedy, was subjected to… Continue reading Isolation of eudesmanes from Pluchea odorata and evaluation of their effects on cancer cell growth and tumor invasiveness in vitro
2017 / Biochimie
Homologous Recombination enables faithful repair of the deleterious double strand breaks of DNA. This pathway relies on Rad51 to catalyze… Continue reading Functional effects of diphosphomimetic mutations at cAbl-mediated phosphorylation sites on Rad51 recombinase activity
2017 / Meat Science
This study investigated the effects of multiple freeze-thaw (F-T) cycles on water mobility, microstructure damage and protein structure changes in… Continue reading Moisture migration, microstructure damage and protein structure changes in porcine longissimus muscle as influenced by multiple freeze-thaw cycles
2017 / Phytochemistry Letters
A new nitrogen-containing phenolic glycoside, moringaside A (1), and a new megastigmane glycoside, moringamegastigmane A (2), were isolated from the… Continue reading Stimulators of acylated ghrelin secretion from Moringa oleifera leaves
2017 / Journal of Chromatography A
G-quadruplex DNA structure is considered to be a very attractive target for antitumor drug design due to its unique role… Continue reading Separation of the potential G-quadruplex ligands from the butanol extract of Zanthoxylum ailanthoides Sieb. & Zucc. by countercurrent chromatography and preparative high performance liquid chromatography
2017 / Journal of Photochemistry and Photobiology B: Biology
Cytarabine is a kind of chemotherapy medication. In the present study, the molecular interaction between cytarabine and human serum albumin… Continue reading Probing the binding reaction of cytarabine to human serum albumin using multispectroscopic techniques with the aid of molecular docking
2017 / European Journal of Medicinal Chemistry
Four series of new hybrid molecules with 7-chloroquinoline and arylamidine moieties joined through the rigid -O- (groups I (2a-g) and II (5a-g)) or flexible… Continue reading New quinoline-arylamidine hybrids: Synthesis, DNA/RNA binding and antitumor activity
2017 / Cellular Signalling
Intrinsically disordered proteins (IDPs) are involved in many pivotal cellular processes including phosphorylation and signalling. The structural and functional effects… Continue reading A phosphorylation-motif for tuneable helix stabilisation in intrinsically disordered proteins – Lessons from the sodium proton exchanger 1 (NHE1)
2017 / International Journal of Biological Macromolecules
It is usually believed that γ-ray interaction with biomolecules is intermediately performed by reactive oxygen species (ROS) produced from radiolysis… Continue reading Preferential role of iron in heme degradation of hemoglobin upon gamma irradiation
2017 / Peptides
Anionic Peptides are molecules rich in aspartic acid (Asp) and/or glutamic acid (Glu) residues in the primary structure. This work presents, for the first time, structural… Continue reading Structure and in vitro activities of a Copper II-chelating anionic peptide from the venom of the scorpion Tityus stigmurus
2017 / Tetrahedron: Asymmetry
A versatile reagent for the chiral resolution and determination of the absolute configuration of benzylic alcohols, (−)-3-menthoxybiphenyl-4-carboxylic acid, is reported.… Continue reading 3-Menthoxybiphenyl-4-carboxylic acid: a versatile resolving agent and reagent for determination of the absolute configuration of benzylic alcohols
2017 / International Journal of Biological Macromolecules
Herein, we investigated the effect of the chitosan nanoparticles (CsNP) on the structure, dynamics, and activity of trypsin. The enzyme… Continue reading Chitosan Nanoparticles-Trypsin Interactions: Bio-physicochemical and Molecular Dynamics Simulation Studies
2017 / Journal of Luminescence
Exploring the binding interaction of drug molecule with calf thymus DNA turn out to be a dynamic field of research… Continue reading Binding interaction of pharmaceutical drug captopril with calf thymus DNA: a multispectroscopic and molecular docking study
2017 / Phytochemistry Letters
A pair of new tetranorlabdane diterpenoid epimers, named elettarins A (1) and B (2), together with five known labdane diterpenes… Continue reading New tetranorlabdane diterpenoids from the fruits of Elettaria cardamomum Maton
2017 / Biochimica et Biophysica Acta (BBA) - General Subjects
Apelin is a peptide ligand for a class A G-protein coupled receptor called the apelin receptor (AR or APJ) that… Continue reading Bioactivity of the putative apelin proprotein expands the repertoire of apelin receptor ligands
2017 / Fish & Shellfish Immunology
Lectins play crucial roles for innate immune responses in invertebrates by recognizing and eliminating pathogens. In this study, a lectin… Continue reading Molecular and functional characterization of a glycosylated Galactose-Binding lectin from Mytilus californianus
2017 / International Journal of Biological Macromolecules
TBC1D4 (also known as AS160) is a Rab·GTPase-activating protein (RabGAP) which functions in insulin signaling. TBC1D4 is critical for translocation… Continue reading The carboxy-terminal region of the TBC1D4 (AS160) RabGAP mediates protein homodimerization
2017 / International Journal of Pharmaceutics
Ethionamide (ETH) is a second line antitubercular drug suffering from poor solubility in water and strong tendency to crystallize. These… Continue reading Efficient loading of ethionamide in cyclodextrin-based carriers offers enhanced solubility and inhibition of drug crystallization
