Found 9617 Results / Page 309 of 481
2017 / Biologicals
Exendin-4 is a GLP 1 agonist incretin-mimetic peptide hormone comprising 39 amino acids. Exenatide (Byetta®) is a chemically synthesized version… Continue reading Microbial expression of Exendin-4 analog and its efficacy in mice model
2017 / Nucleic Acids Research
AGRO100 (also known as AS1411) is a G-rich oligonucleotide that has long been established as a potent anti-cancer aptamer. However,… Continue reading G-quadruplex structure of an anti-proliferative DNA sequence
2017 / Proteins: Structure, Function and Bioinformatics
AlleyCatE is a de novo designed esterase that can be allosterically regulated by calcium ions. This artificial enzyme has been shown to… Continue reading Functional Tuning of the catalytic residue pKa in a de novo Designed Esterase
2017 / Organic & Biomolecular Chemistry
In order to construct artificial viral capsids bearing complementary dimeric coiled-coils on the surface, a β-annulus peptide bearing a coiled-coil… Continue reading Self-assembled artificial viral capsids bearing coiled-coils at the surface
2017 / PLoS ONE
Fluorescence spectroscopy techniques like Förster resonance energy transfer (FRET) and fluorescence correlation spectroscopy (FCS) have become important tools for the in… Continue reading Covalent dye attachment influences the dynamics and conformational properties of flexible peptides
2017 / Frontiers in Biology
Curcumin has emerged to be utilized as a superb beneficial agent, due to its naturally occurring anti-oxidant, anti-inflammatory and anti-carcinogenic… Continue reading Analysis of curcumin interaction with human serum albumin using spectroscopic studies with molecular simulation
2017 / Fitoterapia
Pocahemiketals A and B (1 and 2), two novel hemiketal sesquiterpenoids with unprecedented skeletons, were isolated from the essential oil of the… Continue reading Pocahemiketals A and B, two new hemiketals with unprecedented sesquiterpenoid skeletons from Pogostemon cablin
2017 / Advanced Functional Materials
Enantiomeric glutamate gelators containing a spiropyran moiety are designed and found to self-assemble into a nanohelix through gelation. Upon alternating… Continue reading Reversible Quadruple Switching with Optical, Chiroptical, Helicity, and Macropattern in Self-Assembled Spiropyran Gels
2017 / Biochemistry
Proline utilization A from Escherichia coli (EcPutA) is a multifunctional flavoenzyme that oxidizes proline to glutamate through proline dehydrogenase (PRODH)… Continue reading Identification of a Conserved Histidine as Critical for the Catalytic Mechanism and Functional Switching of the Multifunctional Proline Utilization A Protein
2017 / Organic & Biomolecular Chemistry
While the influence of alkyl chain length and headgroup size on self-assembly behaviour has been well-established for simple surfactants, the… Continue reading Balancing the Intermolecular Forces in Peptide Amphiphiles for Controlling Self-Assembly Transitions
2017 / Journal of Molecular Structure
A new zinc(II) complex, [Zn(L)(H2O)](ClO4) (1) with azo-thioether containing NSNO donor ligand, 3-(2-(2-((pyridin-2-ylmethyl)thio)phenyl)hydrazono)pentane-2,4-dione (HL) is synthesized and characterized by several… Continue reading Synthesis and characterization of a new zinc(II) complex with tetradentate azo-thioether ligand: X-ray structure, DNA binding study and DFT calculation
2017 / Physiological Entomology
In the present study, trypsin from Plodia interpunctella (Hübner) is characterized to discover sequence, biochemical and structural features. This enzyme is purified… Continue reading Biochemical characterization and structural analysis of trypsin from Plodia interpunctella midgut: implication of determinants in extremely alkaline pH activity profile
2017 / Journal of Natural Products
Bioactivity-guided fractionation of the ethyl acetate extract of the leaves of Poupartia borbonica led to the isolation of three new alkyl cyclohexenone… Continue reading Antimalarial Activities of Alkyl Cyclohexenone Derivatives Isolated from the Leaves of Poupartia borbonica
2017 / Inorganic Chemistry
Tristetraprolin (TTP) is a nonclassical zinc finger (ZF) protein that plays a key role in regulating inflammatory response. TTP regulates… Continue reading Cu(I) Disrupts the Structure and Function of the Nonclassical Zinc Finger Protein Tristetraprolin (TTP)
2017 / Chemistry A European Journal
Osteosarcoma is the most common malignant bone tumor primarily affects adolescents. Targeted platinum(II) complexes are promising candidates for overcoming the… Continue reading Dinuclear platinum(II) complexes with bone-targeting groups as potential anti-osteosarcoma agents
2017 / Dalton Transactions
Prion Proteins (PrP) from different species have the ability to tightly bind Cu2+ ions. Copper coordination sites are located at… Continue reading Effect of membrane-mimicking environment on the interactions of Cu2+ with amyloidogenic fragment of chicken Prion protein
2017 / Biophysical Journal
The periplasmic domain of OmpA from Acinetobacter baumannii (AbOmpA-PD) binds to diaminopimelate and anchors the outer membrane to the peptidoglycan layer in… Continue reading Ligand-Mediated Folding of the OmpA Periplasmic Domain from Acinetobacter baumannii
2017 / Journal of Venomous Animals and Toxins including Tropical Diseases
Mass spectrometry-guided venom peptide profiling is a powerful tool to explore novel substances from venomous animals in a highly sensitive… Continue reading Isolation of biologically active peptides from the venom of Japanese carpenter bee, Xylocopa appendiculata
2017 / Dalton Transactions
The investigation of the linkage isomers of biologically essential and kinetically labile metal complexes in aqueous solutions poses a challenge,… Continue reading Exploring the boundaries of direct detection and characterization of labile isomers – a case study of copper(II)-dipeptide systems
2017 / International Journal of Biological Macromolecules
Naturally occurring flavonoid luteolin (LTN) was found to interact with double stranded poly(A).poly(U) and triple stranded poly(U)·poly(A)*poly(U) with association constants… Continue reading Third strand stabilization of poly(U)·poly(A)* poly(U) triplex by the naturally occurring flavone luteolin: A multi-spectroscopic approach
