Leah Pandiscia, PhD
July 28, 2017
Structural rearrangements and condensations of proteins under hyperglycemic stress have been implicated in various pathological disorders. This study aims to… Continue reading Studies on glycoxidatively modified human IgG: Implications in immuno-pathology of type 2 diabetes mellitus
Leah Pandiscia, PhD
July 28, 2017
Haloalkane dehalogenase (HLD) can catalyze the hydrolytic dehalogenation of halogenated compounds. However, HLD suffers from the poor stability to resist… Continue reading PEGylation with the thiosuccinimido butylamine linker significantly increases the stability of haloalkane dehalogenase DhaA
Leah Pandiscia, PhD
July 28, 2017
Biodiesel, an environment friendly alternative for fuels, contains methyl esters of long-chain fatty acids. Our group has reported a methanol-stable… Continue reading Targeted mutations and MD simulations of a methanol-stable lipase YLIP9 from Yarrowia lipolytica MSR80 to develop a biodiesel enzyme
Leah Pandiscia, PhD
July 28, 2017
Five previously undescribed metabolites, including acetylquestinol, two prenylated indole 3-carbaldehyde derivatives, an anthranilic acid derivative and an isochromone derivative, were… Continue reading Antibacterial and antibiofilm activities of the metabolites isolated from the culture of the mangrove-derived endophytic fungus Eurotium chevalieri KUFA 0006
Leah Pandiscia, PhD
July 28, 2017
Nine new phenalenone derivatives (1–9), along with two known analogues (10 − 11) have been isolated from the solid cultures of an… Continue reading New phenalenone derivatives from Pinellia ternata tubers derived Aspergillus sp.
Leah Pandiscia, PhD
July 28, 2017
The interaction of antimicrobial peptides (AMPs) with biological membranes is in the focus of research since several years, and the… Continue reading The interaction of antimicrobial peptides with membranes
Leah Pandiscia, PhD
July 28, 2017
Blood coagulation and platelet-dependent primary homeostasis are important defense mechanisms against bleeding and novel inhibitors have been researched to obtain… Continue reading Can γ-radiation modulate hemagglutinating and anticoagulant activities of PpyLL, a lectin from Phthirusa pyrifolia?
Leah Pandiscia, PhD
July 28, 2017
SET-M33 is a multimeric antimicrobial peptide active against Gram-negative bacteria in vitro and in vivo. Insights into its killing mechanism could elucidate correlations… Continue reading Investigations into the killing activity of an antimicrobial peptide active against extensively antibiotic-resistant K. pneumoniae and P. aeruginosa
Leah Pandiscia, PhD
July 28, 2017
The branched chains in diphytanoyl lipids provide membranes with unique properties, such as high chemical/physical stability, low water permeability, and… Continue reading Diphytanoyl lipids as model systems for studying membrane-active peptides
Leah Pandiscia, PhD
July 28, 2017
Zijuan tea is a special cultivar of Yunnan broad-leaf tea (Camellia sinensis var. assamica) with purple buds, leaves, and stems. Phytochemical… Continue reading Novel acetylcholinesterase inhibitors from Zijuan tea and biosynthetic pathway of caffeoylated catechin in tea plant
Leah Pandiscia, PhD
July 28, 2017
Protein Arginine Methyltransferase 7 (PRMT7) catalyzes the introduction of mono methylation marks at the arginine residues of substrate proteins. PRMT7… Continue reading PRMT7 interacts with ASS1 and citrullinemia mutations disrupt the interaction
Leah Pandiscia, PhD
July 28, 2017
We prepared various chiral α-alkyl, β-aryl ketones with good to excellent enantiomeric excess through the Baker’s yeast asymmetric double-bond reduction… Continue reading Extractive biocatalysis in the asymmetric reduction of α-alkyl, β-aryl enones by Baker’s yeast
Leah Pandiscia, PhD
July 28, 2017
Adenosine is an endogenous nucleotide pivotally involved in nucleic acid and energy metabolism. Its excessive existence may indicate tumorigenesis, typically… Continue reading G-quadruplex based Exo III-assisted signal amplification aptasensor for the colorimetric detection of adenosine
Leah Pandiscia, PhD
July 28, 2017
Glutamine synthetase (GS) catalyzes the ATP-dependent formation of glutamine from glutamate and ammonia. The activity of Synechocystis sp. PCC 6803 GS type… Continue reading The isolated, twenty-three-residue-long, N-terminal region of the glutamine synthetase inactivating factor binds to its target
Leah Pandiscia, PhD
July 28, 2017
In photosynthetic organisms, transketolase (TK) is involved in the Calvin-Benson cycle and participates to the regeneration of ribulose-5-phosphate. Previous studies… Continue reading Structural basis for the magnesium-dependent activation of transketolase from Chlamydomonas reinhardtii
Leah Pandiscia, PhD
July 28, 2017
A plethora of evidence suggests that different types of DNA quadruplexes are widely present in the genome of all organisms.… Continue reading Probing the Potential Role of Non-B DNA Structures at Yeast Meiosis-Specific DNA Double-Strand Breaks
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Self-assembly of zinc salt with rationally designed chiral ligand, (1R,2R)-2-(pyridine-4-yl carbamoyl) cyclohexanecarboxylic acid (RR-PCCH) generated 2D homochiral metal-organic framework [Zn(RR-PCCHC)2]… Continue reading Homochiral MOF as Circular Dichroism Sensor for Enantioselective Recognition on Nature and Chirality of Unmodified Amino Acids
Leah Pandiscia, PhD
July 28, 2017
The process of controlled cellular death known as apoptosis has an important central role not only in normal homeostatic maintenance… Continue reading An enhanced bioluminescence-based Annexin V probe for apoptosis detection in vitro and in vivo
Leah Pandiscia, PhD
July 28, 2017
