Found 9617 Results / Page 316 of 481
2017 / PNAS
CDC14 is an essential dual-specificity phosphatase that counteracts CDK1 activity during anaphase to promote mitotic exit in Saccharomyces cerevisiae. Surprisingly, human… Continue reading Human phosphatase CDC14A regulates actin organization through dephosphorylation of epithelial protein lost in neoplasm
2017 / Analytical Chemistry
Trifluoroacetate (TFA) is a strong anion byproduct of solid phase peptide synthesis. Fourier transform infrared (FT-IR) spectroscopy can be used… Continue reading 2D IR Correlation Spectroscopy in the Determination of Aggregation and Stability of KH Domain GXXG Loop Peptide in the Presence and Absence of Trifluoroacetate
2017 / Journal of Natural Medicines
Three new spongian diterpenes, ceylonins G–I (1–3), were isolated from the marine sponge Spongia ceylonensis collected in Indonesia, together with… Continue reading Ceylonins G–I: spongian diterpenes from the marine sponge Spongia ceylonensis
2017 / Biophysical Chemistry
We investigated the effects of punctual A-to-V and A-to-T mutations in the amyloid precursor protein APP, corresponding to position 2… Continue reading Pathogenic Aβ A2V versus protective Aβ A2T mutation: Early stage aggregation and membrane interaction
2017 / Pesticide Biochemistry and Physiology
Analysis of the interaction of pesticides and their metabolites with the cellular proteins has drawn considerable attention in past several… Continue reading Solvent-dependent binding interactions of the organophosphate pesticide, chlorpyrifos (CPF), and its metabolite, 3,5,6-trichloro-2-pyridinol (TCPy), with Bovine Serum Albumin (BSA): A comparative fluorescence quenching analysis ☆
2017 / Plant Physiology and Biochemistry
Light quality is an important environmental factor affecting the biosynthesis of photosynthetic pigments whose production seems to be affected not… Continue reading Monochromatic green light induces an aberrant accumulation of geranylgeranyled chlorophylls in plants
2017 / Acta Biomaterialia
Introducing cell-selectivity in antimicrobial peptides (AMPs) without compromising the antimicrobial and anti-endotoxin properties is a crucial step towards the development… Continue reading Selective phenylalanine to proline substitution for improved antimicrobial and anticancer activities of peptides designed on phenylalanine heptad repeat
2017 / Journal of Photochemistry and Photobiology B: Biology
The present work reveals the study of interaction of a promising chemotherapeutic drug ciprofloxacin (CFX) with a model transport protein… Continue reading Binding of ciprofloxacin to bovine serum albumin: Photophysical and thermodynamic aspects
2017 / Cytokine
Cytokine-like protein 1 (CYTL1) is a small widely expressed secreted protein lacking significant primary sequence homology to any other known… Continue reading Biochemical and biophysical characterization of cytokine-like protein 1 (CYTL1)
2017 / Biochimie
Interleukin-22 (IL-22) belongs to the family of IL-10 cytokines and is involved in a wide number of human diseases, including… Continue reading Characterization of linear mimetic peptides of Interleukin-22 from dissection of protein interfaces
2017 / Phytochemistry Letters
Two new flavanone glycosides, named scugalerosides A and B (1-2), were isolated from the whole plant of Scutellaria galericulata. Their chemical… Continue reading Two new flavanone glycosides from Scutellaria galericulata with anti-inflammatory activities
2017 / International Journal of Biological Macromolecules
The SDS-glycoprotein system is mimic of membrane protein-lipid system. Fate of glycoprotein, conformation and the interactive forces involved in membrane… Continue reading Mechanistic insight into interaction of Sodium Dodecyl Sulphate to asialylated form of glycoprotein: a mimic of membrane protein-lipid system
2017 / International Journal of Biological Macromolecules
The self-assembled polypseudorotaxane (PPRX) fabricated with bis-thiolated poly(ethylene glycol) (PEG) and α-cyclodextrin (α-CyD) acted as an activator for α-chymotrypsin (CT) and retained… Continue reading α-Chymotrypsin activated and stabilized by self-assembled polypseudorotaxane fabricated with bis-thiolated poly(ethylene glycol) and α-cyclodextrin: spectroscopic and mechanistic analysis
2017 / Journal of Fluorine Chemistry
In the present work, the interaction between HSA with three potential anti-trypanosomal drugs – (E)-2-benzylidene-hydrazine-carbothioamide (UTS); (E)-2-(3,4-difluoro-benzylidene)-hydrazine-carbothioamide (DFTS) and (E)-2-(2,3,4-trifluoro-benzylidene)-hydrazine-carbothioamide… Continue reading Investigation of interaction between human plasmatic albumin and potential fluorinated anti-trypanosomal drugs
2013 / PNAS
Stapled α−helical peptides have emerged as a promising new modality for a wide range of therapeutic targets. Here, we report… Continue reading Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
2012 / PNAS
Curli are extracellular proteinaceous functional amyloid aggregates produced by Escherichia coli, Salmonella spp., and other enteric bacteria. Curli mediate host… Continue reading The E. coli CsgB nucleator of curli assembles to β-sheet oligomers that alter the CsgA fibrillization mechanism
2012 / PNAS
Interactions of cytochrome c (cyt c) with cardiolipin (CL) are important for both electron transfer and apoptotic functions of this… Continue reading Conformational properties of cardiolipin-bound cytochrome c
2013 / PNAS
Conditionally disordered proteins can alternate between highly ordered and less ordered configurations under physiological conditions. Whereas protein function is often… Continue reading Chaperone activation by unfolding
2011 / PNAS
A heterologously expressed form of the human Parkinson diseaseassociated protein α-synuclein with a 10-residue N-terminal extension is shown to form… Continue reading A soluble α-synuclein construct forms a dynamic tetramer
2011 / PNAS
The process of lipid droplet (LD) formation is an evolutionarily conserved process among all eukaryotes and plays an important role… Continue reading Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation
