Found 9617 Results / Page 317 of 481
2011 / PNAS
Acyl-homoserine lactone (AHL) quorum sensing controls gene expression in hundreds of Proteobacteria including a number of plant and animal pathogens.… Continue reading Crystal structure of QscR, a Pseudomonas aeruginosa quorum sensing signal receptor
2013 / PNAS
The HIV-1 Tat protein stimulates viral gene expression by recruiting human transcription elongation complexes containing P-TEFb, AFF4, ELL2, and ENL… Continue reading HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold
2008 / PNAS
Bleomycin (BLM) is a glycopeptide anticancer drug that effectively carries out single- and double-stranded DNA cleavage. Activated BLM (ABLM), a… Continue reading Further insights into the mechanism of the reaction of activated bleomycin with DNA
2011 / PNAS
Respiratory syncytial virus (RSV), the main cause of infant bronchiolitis, remains a major unmet vaccine need despite more than 40… Continue reading Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers
2011 / PNAS
Protein kinase A (PKA) is a ubiquitous phosphoryl transferase that mediates hundreds of cell signaling events. During turnover, its catalytic… Continue reading Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy
2012 / PNAS
The homotypic fusion of endoplasmic reticulum (ER) membranes is mediated by atlastin (ATL), which consists of an N-terminal cytosolic domain… Continue reading Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion
2011 / PNAS
A series of two-dimensional infrared vibrational echo experiments performed on nitrile-labeled villin headpiece [HP35-ðCNÞ2] is described. HP35 is a small… Continue reading Dynamics of the folded and unfolded villin headpiece (HP35) measured with ultrafast 2D IR vibrational echo spectroscopy
2011 / PNAS
Several point mutations in human γD-crystallin (HGD) are now known to be associated with cataract. So far, the in vitro… Continue reading Cataract-associated mutant E107A of human γD-crystallin shows increased attraction to α-crystallin and enhanced light scattering
2010 / PNAS
Pmel17 is a functional amyloidogenic protein whose fibrils act as scaffolds for pigment deposition in human skin and eyes. We… Continue reading Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17
2012 / PNAS
Polycomb Group (PcG) proteins mediate heritable gene silencing by modifying chromatin structure. An essential PcG complex, PRC1, compacts chromatin and… Continue reading A core subunit of Polycomb repressive complex 1 is broadly conserved in function but not primary sequence
2010 / PNAS
We show herein that the Salmonella pathogenicity island 2 (SPI2) response regulator SsrB undergoes S-nitrosylation upon exposure of Salmonella to… Continue reading Redox sensor SsrB Cys203 enhances Salmonella fitness against nitric oxide generated in the host immune response to oral infection
2009 / PNAS
The insertion efficiency of transmembrane (TM) helices by the Sec61 translocon depends on helix amino acid composition, the positions of… Continue reading Insertion of short transmembrane helices by the Sec61 translocon
2010 / PNAS
Glutamatergic synaptic transmission is terminated by members of the excitatory amino acid transporter (EAAT) family of proteins that remove glutamate… Continue reading The 3-4 loop of an archaeal glutamate transporter homolog experiences ligand-induced structural changes and is essential for transport
2010 / PNAS
Mutations in the dystrophin gene cause Duchenne muscular dystrophy (DMD) most commonly through loss of protein expression. In a small… Continue reading Disease-causing missense mutations in actin binding domain 1 of dystrophin induce thermodynamic instability and protein aggregation
2014 / PNAS
Long-time molecular dynamics (MD) simulations are now able to fold small proteins reversibly to their native structures [Lindorff-Larsen K, Piana… Continue reading Benchmarking all-atom simulations using hydrogen exchange
2014 / PNAS
Intrinsically disordered protein regions are widely distributed in the cytoplasmic domains of many transmembrane receptors. The cytoplasmic domain of a… Continue reading Membrane-enabled dimerization of the intrinsically disordered cytoplasmic domain of ADAM10
2015 / PNAS
Mutations in profilin 1 (PFN1) are associated with amyotrophic lateral sclerosis (ALS); however, the pathological mechanism of PFN1 in this… Continue reading Structural basis for mutation-induced destabilization of profilin 1 in ALS
2014 / PNAS
Although many transcription activators contact the same set of coactivator complexes, the mechanism and specificity of these interactions have been… Continue reading A sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface
2013 / PNAS
Intrinsically disordered proteins play crucial roles in regulatory processes and often function as protein interaction hubs. Here, we present a… Continue reading Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions
2014 / PNAS
Commensal and pathogenic bacteria must deal with many different stress conditions to survive in and colonize the human gastrointestinal tract.… Continue reading Bile salts act as effective protein-unfolding agents and instigators of disulfide stress in vivo
