Found 9617 Results / Page 318 of 481
2012 / PNAS
Iron, an essential nutrient with limited bioavailability, requires specialized cellular mechanisms for uptake. Although iron uptake into the cytoplasm in… Continue reading Induced fit on heme binding to the Pseudomonas aeruginosa cytoplasmic protein (PhuS) drives interaction with heme oxygenase (HemO)
2011 / PNAS
Peroxisome proliferator activated receptor (PPAR) γ coactivator-1α (PGC-1α) is a potent transcriptional coactivator of oxidative metabolism and is induced in… Continue reading Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex
2010 / PNAS
Perception and response to nutritional iron availability by bacteria are essential to control cellular iron homeostasis. The Irr protein from Bradyrhizobium… Continue reading Control of bacterial iron homeostasis by manganese
2013 / PNAS
Within Cu-containing electron transfer active sites, the role of the axial ligand in type 1 sites is well defined, yet… Continue reading Axial interactions in the mixed-valent CuA active site and role of the axial methionine in electron transfer
2014 / PNAS
Hypochlorite, an oxidant generated in vivo by the innate immune system, kills invading pathogens largely by inducing the misfolding of… Continue reading Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin
2013 / PNAS
Resorcylic acid lactones and dihydroxyphenylacetic acid lactones represent important pharmacophores with heat shock response and immune system modulatory activities. The… Continue reading Rational reprogramming of fungal polyketide first-ring cyclization
2013 / PNAS
Although amyloid β (Aβ) is a critical player in the pathology of Alzheimer’s disease, there is currently little Information on… Continue reading Quantitative analysis of the time course of Aβ oligomerization and subsequent growth steps using tetramethylrhodamine-labeled Aβ
2012 / PNAS
Basic leucine zipper (bZip) transcription factors regulate cellular gene expression in response to a variety of extracellular signals and nutrient… Continue reading Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2
2012 / PNAS
Many toxins assemble into oligomers on the surface of cells. Local chemical cues signal and trigger critical rearrangements of the… Continue reading Anthrax toxin protective antigen integrates poly-γ-D-glutamate and pH signals to sense the optimal environment for channel formation
2013 / PNAS
Excited states of proteins may play important roles in function, yet are difficult to study spectroscopically because of their sparse… Continue reading Circular dichroism and site-directed spin labeling reveal structural and dynamical features of high-pressure states of myoglobin
2013 / PNAS
The studies presented here explore the relationship between protein packing and molecular flexibility using ligand-binding cavity mutants of T4 lysozyme.… Continue reading Conformational selection and adaptation to ligand binding in T4 lysozyme cavity mutants
2011 / PNAS
The histone fold forms the fundamental endoskeleton of the protein core of the nucleosome and is also found in several… Continue reading Experimental evidence for the role of domain swapping in the evolution of the histone fold
2012 / PNAS
S ¼ 2 FeIV═O species are key intermediates in the catalysis of most nonheme iron enzymes. This article presents detailed… Continue reading π-Frontier molecular orbitals in S = 2 ferryl species and elucidation of their contributions to reactivity
2012 / PNAS
To provide high-resolution X-ray crystallographic structures of a peptide with the Trp-cage fold, we prepared a cyclized version of this… Continue reading Crystal and NMR structures of a Trp-cage mini-protein benchmark for computational fold prediction
2014 / The Journal of Biological Chemistry
Aβ42 oligomers play key roles in the pathogenesis of Alzheimer disease, but their structures remain elusive partly due to their… Continue reading Antiparallel Triple-strand Architecture for Prefibrillar Aβ42 Oligomers
2017 / PNAS
DNA glycosylases are important editing enzymes that protect genomic stability by excising chemically modified nucleobases that alter normal DNA metabolism.… Continue reading Structure of a DNA glycosylase that unhooks interstrand cross-links
2017 / PNAS
Cytochrome c (cyt c), required for electron transport in mitochondria, possesses a covalently attached heme cofactor. Attachment is catalyzed by… Continue reading Engineered holocytochrome c synthases that biosynthesize new cytochromes c
2016 / PNAS
The covalent modification of therapeutic biomolecules has been broadly explored, leading to a number of clinically approved modified protein drugs.… Continue reading Supramolecular PEGylation of biopharmaceuticals
2016 / PNAS
Parkinson’s disease is a highly debilitating neurodegenerative condition whose pathological hallmark is the presence in nerve cells of proteinacious deposits,… Continue reading Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation
2015 / PNAS
Despite the ubiquity of helical membrane proteins in nature and their pharmacological importance, the mechanisms guiding their folding remain unclear.… Continue reading Cooperative folding of a polytopic α-helical membrane protein involves a compact N-terminal nucleus and nonnative loops
