Found 9617 Results / Page 319 of 481
2017 / PNAS
The self-assembly of α-synuclein is closely associated with Parkinson’s disease and related syndromes. We show that squalamine, a natural product… Continue reading A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
2016 / PNAS
Curli, consisting primarily of major structural subunit CsgA, are functional amyloids produced on the surface of Escherichia coli, as well as… Continue reading Solution NMR structure of CsgE: Structural insights into a chaperone and regulator protein important for functional amyloid formation
2014 / PNAS
Cysteine-bound hemes are key components of many enzymes and biological sensors. Protonation (deprotonation) of the Cys ligand often accompanies redox… Continue reading Redox-dependent stability, protonation, and reactivity of cysteine-bound heme proteins
2015 / PNAS
The autoactivation of an initiating serine protease upon binding of pattern recognition proteins to pathogen surfaces is a crucial step… Continue reading Initiating protease with modular domains interacts with β-glucan recognition protein to trigger innate immune response in insects
2015 / PNAS
Fast protein folding involves complex dynamics in many degrees of freedom, yet microsecond folding experiments provide only low-resolution structural information.… Continue reading Mapping fast protein folding with multiple-site fluorescent probes
2015 / PNAS
Aromatic polyketides make up a large class of natural products with diverse bioactivity. During biosynthesis, linear poly-β-ketone intermediates are regiospecifically… Continue reading Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthases
2016 / PNAS
G-quadruplex (GQ) is a four stranded DNA secondary structure that arises from a guanine rich sequence. Stable formation of GQ… Continue reading Single-molecule imaging reveals a common mechanism shared by G-quadruplex–resolving helicases
2016 / PNAS
Our understanding of how the endoplasmic reticulum (ER)-associated protein degradation (ERAD) machinery efficiently targets terminally misfolded proteins while avoiding the… Continue reading Htm1p–Pdi1p is a folding-sensitive mannosidase that marks N-glycoproteins for ER-associated protein degradation
2015 / PNAS
Residue-level unfolding of two helix-turn-helix proteins—one naturally occurring and one de novo designed—is reconstructed from multiple sets of site-specific 13C isotopically… Continue reading Sequence, structure, and cooperativity in folding of elementary protein structural motifs
2015 / PNAS
The ability to predictably control the coassembly of multiple nanoscale building blocks, especially those with disparate chemical and physical properties… Continue reading DNA-mediated engineering of multicomponent enzyme crystals
2016 / PNAS
γ-Secretase is an intramembrane-cleaving protease that processes many type-I integral membrane proteins within the lipid bilayer, an event preceded by… Continue reading Nicastrin functions to sterically hinder γ-secretase–substrate interactions driven by substrate transmembrane domain
2016 / PNAS
Bacterial biofilm formation during chronic infections confers increased fitness, antibiotic tolerance, and cytotoxicity. In many pathogens, the transition from a… Continue reading Mechanistic insights into c-di-GMP–dependent control of the biofilm regulator FleQ from Pseudomonas aeruginosa
2014 / PNAS
Combinatorial biosynthesis aspires to exploit the promiscuity of microbial anabolic pathways to engineer the synthesis of new chemical entities. Fungal… Continue reading Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases
2014 / PNAS
Protein toxins from tarantula venom alter the activity of diverse ion channel proteins, including voltage, stretch, and ligandactivated cation channels.… Continue reading Structural interactions of a voltage sensor toxin with lipid membranes
2015 / The Journal of Biological Chemistry
Bacterial viruses of the P22-like family encode a specialized tail needle essential for genome stabilization after DNA packaging and implicated… Continue reading Structural Plasticity of the Protein Plug That Traps Newly Packaged Genomes in Podoviridae Virions
2015 / The Journal of Biological Chemistry
Prestin is the motor protein of cochlear outer hair cells. Its unique capability to perform direct, rapid, and reciprocal electromechanical… Continue reading Glutamate Transporter Homolog-based Model Predicts That Anion-π Interaction Is the Mechanism for the Voltage-dependent Response of Prestin
2015 / The Journal of Biological Chemistry
Antibodies with conformational specificity are important for detecting and interfering with polypeptide aggregation linked to several human disorders. We are… Continue reading Design and Optimization of Anti-amyloid Domain Antibodies Specific for β-Amyloid and Islet Amyloid Polypeptide
2015 / The Journal of Biological Chemistry
Escherichia coli harbors two highly conserved homologs of the essential mitochondrial respiratory complex II (succinate:ubiquinone oxidoreductase). Aerobically the bacterium synthesizes succinate:quinone… Continue reading Binding of the Covalent Flavin Assembly Factor to the Flavoprotein Subunit of Complex II
2015 / The Journal of Biological Chemistry
Segment 5, ORF 1 of the infectious salmon anemia virus (ISAV) genome, encodes for the ISAV F protein, which is… Continue reading Electrostatic Architecture of the Infectious Salmon Anemia Virus (ISAV) Core Fusion Protein Illustrates a Carboxyl-Carboxylate pH Sensor
2014 / The Journal of Biological Chemistry
Bacterial cell membranes contain several protein pumps that resist the toxic effects of drugs by efficiently extruding them. One family… Continue reading Efflux by Small Multidrug Resistance Proteins Is Inhibited by Membrane-interactive Helix-stapled Peptides
