Found 9617 Results / Page 320 of 481
2015 / The Journal of Biological Chemistry
ATP-binding cassette (ABC) transporters of the cluster 9 family are ubiquitous among bacteria and essential for acquiring Zn2+ and Mn2+ from the… Continue reading Transcriptional Regulation, Metal Binding Properties and Structure of Pden1597, an Unusual Zinc Transport Protein from Paracoccus denitrificans
2014 / The Journal of Biological Chemistry
Amyloid light chain (AL) amyloidosis is a protein misfolding disease where immunoglobulin light chains sample partially folded states that lead… Continue reading Differential Effects on Light Chain Amyloid Formation Depend on Mutations and Type of Glycosaminoglycans
2015 / The Journal of Biological Chemistry
Aromatase (CYP19A1), the enzyme that converts androgens to estrogens, is of significant mechanistic and therapeutic interest. Crystal structures and computational… Continue reading Evidence for an Elevated Aspartate pKa in the Active Site of Human Aromatase
2014 / The Journal of Biological Chemistry
Mutations in glucocerebrosidase (GCase), the enzyme deficient in Gaucher disease, are a common genetic risk factor for the development of… Continue reading Structural Features of Membrane-bound Glucocerebrosidase and α-Synuclein Probed by Neutron Reflectometry and Fluorescence Spectroscopy
2013 / The Journal of Biological Chemistry
Low density lipoprotein receptor (LDLR) was shown to mediate clearance of blood coagulation factor VIII (FVIII) from the circulation. To… Continue reading Mapping the Binding Region on the Low Density Lipoprotein Receptor for Blood Coagulation Factor VIII
2012 / The Journal of Biological Chemistry
Misfolding and aggregation of huntingtin is one of the hallmarks of Huntington disease, but the overall structure of these aggregates… Continue reading Structural Features and Domain Organization of Huntingtin Fibrils
2015 / The Journal of Biological Chemistry
The low density lipoprotein receptor-related protein 1 (LRP1) is a member of the low density lipoprotein receptor family and plays… Continue reading Generation of a Potent Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Antagonist by Engineering a Stable Form of the Receptor-associated Protein (RAP) D3 Domain
2014 / The Journal of Biological Chemistry
Chlamydia is an intracellular bacterium that establishes residence within parasitophorous compartments (inclusions) inside host cells. Chlamydial inclusions are uncoupled from the… Continue reading An α-Helical Core Encodes the Dual Functions of the Chlamydial Protein IncA
2015 / The Journal of Biological Chemistry
Double-stranded RNA (dsRNA)-activated protein kinase (PKR) is an important component of the innate immune system that presents a crucial first… Continue reading The Regulatory and Kinase Domains but Not the Interdomain Linker Determine Human Double-stranded RNA-activated Kinase (PKR) Sensitivity to Inhibition by Viral Non-coding RNAs
2015 / The Journal of Biological Chemistry
IRF4 is a unique member of the interferon regulatory factor (IRF) family playing critical regulatory roles in immune cell development,… Continue reading Structural Studies of IRF4 Reveal a Flexible Autoinhibitory Region and a Compact Linker Domain
2015 / The Journal of Biological Chemistry
Previous studies revealed an essential role for the lipid-binding Sec14 domain of kalirin (KalSec14), but its mechanism of action is… Continue reading An N-terminal Amphipathic Helix Binds Phosphoinositides and Enhances Kalirin Sec14 Domain-mediated Membrane Interactions
2015 / The Journal of Biological Chemistry
Nearly all mitochondrial proteins are coded by the nuclear genome and must be transported into mitochondria by the translocase of… Continue reading Evidence of Distinct Channel Conformations and Substrate Binding Affinities for the Mitochondrial Outer Membrane Protein Translocase Pore Tom40
2013 / The Journal of Biological Chemistry
The activation of pyruvate formate-lyase (PFL) by pyruvate formate-lyase activating enzyme (PFL-AE) involves formation of a specific glycyl radical on… Continue reading Pyruvate Formate-lyase and Its Activation by Pyruvate Formate-lyase Activating Enzyme
2015 / The Journal of Biological Chemistry
We previously identified Treponema pallidum repeat proteins TprC/D, TprF, and TprI as candidate outer membrane proteins (OMPs) and subsequently demonstrated that TprC is… Continue reading Bipartite Topology of Treponema pallidumRepeat Proteins C/D and I
2015 / The Journal of Biological Chemistry
EsxA (ESAT-6), an important virulence factor of Mycobacterium tuberculosis, plays an essential role in phagosome rupture and bacterial cytosolic translocation within… Continue reading Characterization of Mycobacterium tuberculosis EsxA Membrane Insertion
2015 / The Journal of Biological Chemistry
Although trace levels of phosphorylated α-synuclein (α-syn) are detectable in normal brains, nearly all α-syn accumulated within Lewy bodies in… Continue reading Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization
2016 / The Journal of Biological Chemistry
Identification of factors contributing to the development of chronic obstructive pulmonary disease (COPD) is crucial for developing new treatments. An… Continue reading Adverse Outcomes Associated with Cigarette Smoke Radicals Related to Damage to Protein-disulfide Isomerase
2016 / The Journal of Biological Chemistry
Cellular membrane disruption induced by β-amyloid (Aβ) peptides has been considered one of the major pathological mechanisms for Alzheimer disease.… Continue reading Distinct Membrane Disruption Pathways Are Induced by 40-Residue β-Amyloid Peptides
2015 / The Journal of Biological Chemistry
Protein modification by small ubiquitin-related modifiers (SUMOs) is essential and conserved in the malaria parasite, Plasmodium falciparum. We have previously shown… Continue reading haracterization and Structural Insights into Selective E1-E2 Interactions in the Human and Plasmodium falciparum SUMO Conjugation Systems
2015 / The Journal of Biological Chemistry
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that trimethylates elongation factor-thermo-unstable (EF-Tu) on lysine 5. Lysine 5 methylation occurs in a… Continue reading Pseudomonas aeruginosa EftM Is a Thermoregulated Methyltransferase
