Found 9617 Results / Page 321 of 481
2015 / The Journal of Biological Chemistry
Bla g 2 is a major indoor cockroach allergen associated with the development of asthma. Antigenic determinants on Bla g… Continue reading Antigenic Determinants of the Bilobal Cockroach Allergen Bla g 2
2016 / The Journal of Biological Chemistry
Some members of the class A β-lactamase family are capable of conferring resistance to the last resort antibiotics, carbapenems. A… Continue reading Role of the Conserved Disulfide Bridge in Class A Carbapenemases
2016 / The Journal of Biological Chemistry
All-trans-retinoic acid may be an important molecular signal in the postnatal control of eye size. The goal of this study… Continue reading Identification of Apolipoprotein A-I as a Retinoic Acid-binding Protein in the Eye
2016 / The Journal of Biological Chemistry
Development of a Plasmodium falciparum (Pf) transmission blocking vaccine (TBV) has the potential to significantly impact malaria control. Antibodies elicited against sexual… Continue reading Structural and Immunological Characterization of Recombinant 6-Cysteine Domains of the Plasmodium falciparum Sexual Stage Protein Pfs230
2016 / The Journal of Biological Chemistry
Cone photoreceptor cyclic nucleotide-gated (CNG) channels play a pivotal role in cone phototransduction, which is a process essential for daylight… Continue reading The B3 Subunit of the Cone Cyclic Nucleotide-gated Channel Regulates the Light Responses of Cones and Contributes to the Channel Structural Flexibility
2016 / The Journal of Biological Chemistry
The LDL receptor-related protein 1 (LRP1) is a large endocytic receptor that binds and mediates the endocytosis of numerous structurally… Continue reading igh Affinity Binding of the Receptor-associated Protein D1D2 Domains with the Low Density Lipoprotein Receptor-related Protein (LRP1) Involves Bivalent Complex Formation
2017 / The Journal of Biological Chemistry
The cobalamin or B12 cofactor supports sulfur and one-carbon metabolism and the catabolism of odd-chain fatty acids, branched-chain amino acids and… Continue reading Coordination Chemistry Controls the Thiol Oxidase Activity of the B12 Trafficking Protein CblC
2017 / The Journal of Biological Chemistry
Protein-tyrosine phosphatase receptor type G (RPTPγ/PTPRG) interacts in vitro with contactin-3–6 (CNTN3–6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the… Continue reading Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues
2016 / The Journal of Biological Chemistry
The sirtuin family of proteins catalyze the NAD+-dependent deacylation of acyl-lysine residues. Humans encode seven sirtuins (Sirt1–7), and recent studies… Continue reading Mechanism of Sirt1 NAD+-dependent Protein Deacetylase Inhibition by Cysteine S-Nitrosation
2015 / The Journal of Biological Chemistry
Bacterial ATP-binding cassette (ABC) transporters of transition metals are essential for acquisition of necessary elements from the environment. A large… Continue reading AztD, a Periplasmic Zinc Metallochaperone to an ATP-binding Cassette (ABC) Transporter System in Paracoccus denitrificans
2017 / The Journal of Biological Chemistry
Peripherin-2/rds is required for biogenesis of vertebrate photoreceptor outer segment organelles. Its localization at the high curvature rim domains of… Continue reading An Inducible Amphipathic Helix Within the Intrinsically Disordered C-terminus is not Required for Protein Biosynthesis, Trafficking, or GARP2 Interaction, but can Participate in Membrane Curvature Generation by Peripherin-2/rds.
2015 / The Journal of Biological Chemistry
Islet amyloid polypeptide (IAPP) is a 37-amino acid amyloid protein intimately associated with pancreatic islet β-cell dysfunction and death in… Continue reading Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption
2016 / The Journal of Biological Chemistry
Cells engage numerous signaling pathways in response to oxidative stress that together repair macromolecular damage or direct the cell toward… Continue reading Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress
2016 / The Journal of Biological Chemistry
Multiple neurodegenerative diseases are caused by the aggregation of the human α-Synuclein (α-Syn) protein. α-Syn possesses high structural plasticity and… Continue reading Preparation and Characterization of Stable α-Synuclein Lipoprotein Particles
2017 / Journal of Nanobiotechnology
Small interfering RNAs (siRNAs) are powerful tools to control gene expression. However, due to their poor cellular permeability and stability,… Continue reading A retro-inverso cell-penetrating peptide for siRNA delivery
2017 / The Journal of Biological Chemistry
Inositol 1,3,4,5,6-pentakisphosphate 2-kinases (IP5 2-Ks) comprise a family of enzymes in charge of synthesizing inositol hexakisphosphate (IP6) in eukaryotic cells. This… Continue reading The Crystal Structure of Mammalian Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase Reveals a New Zinc Binding Site and Key Features for Protein Function
2017 / The Journal of Biological Chemistry
The gp120 subunit of HIV-1 envelope (Env) protein is heavily glycosylated at approximately 25 glycosylation sites, of which ~7-8 are… Continue reading Glycosylation of the core of the HIV-1 envelope subunit protein gp120 is not required for native trimer formation or viral infectivity
2016 / The Journal of Biological Chemistry
The reversible thermal denaturation of apo α-lactalbumin (α-LA) and lysozyme was measured in the absence and presence of multiple concentrations… Continue reading The pH Dependence of Saccharides’ Influence on Thermal Denaturation of Two Model Proteins Supports an Excluded Volume Model for Stabilization Generalized to Allow for Intramolecular Electrostatic Interactions
2016 / The Journal of Biological Chemistry
Mammalian cytochrome c (Cytc) plays a key role in cellular life and death decisions, functioning as an electron carrier in the electron… Continue reading Phosphorylation of Cytochrome c Threonine 28 Regulates Electron Transport Chain Activity in Kidney
2017 / The Journal of Biological Chemistry
Nitrovasodilators relax vascular smooth-muscle cells in part by modulating the interaction of the C-terminal coiled-coil domain (CC) and/or the leucine… Continue reading NMR insight into myosin-binding subunit coiled-coil structure reveals binding interface with protein kinase G-Iα leucine zipper in vascular function
