Found 9617 Results / Page 322 of 481
2017 / The Journal of Biological Chemistry
The ExoU type III secretion enzyme is a potent phospholipase A2 secreted by the Gram-negative opportunistic pathogen, Pseudomonas aeruginosa. Activation of phospholipase… Continue reading Cooperative Substrate-Cofactor Interactions and Membrane Localization of the Bacterial Phospholipase A2 (PLA2) Enzyme, ExoU
2016 / The Journal of Biological Chemistry
Glucagon-like peptide-1 (GLP-1) signaling through the glucagon-like peptide 1 receptor (GLP-1R) is a key regulator of normal glucose metabolism, and… Continue reading Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro
2016 / The Journal of Biological Chemistry
Pseudomonas aeruginosa acquires extracellular heme via the Phu (Pseudomonas heme uptake) and Has (heme assimilation system) systems.We have previously shown… Continue reading Metabolite-driven Regulation of Heme Uptake by the Biliverdin IXβ/δ-Selective Heme Oxygenase (HemO) of Pseudomonas aeruginosa
2017 / The Journal of Biological Chemistry
Caspases are cysteine aspartate proteases that are major players in key cellular processes, including apoptosis and inflammation. Specifically, caspase-6 has… Continue reading Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding
2017 / The Journal of Biological Chemistry
The KRAS GTPase plays a critical role in the control of cellular growth. The activity of KRAS is regulated by… Continue reading A KRAS GTPase K104Q Mutant Retains Downstream Signaling by Offsetting Defects in Regulation
2016 / The Journal of Biological Chemistry
Calreticulin is a lectin chaperone of the endoplasmic reticulum that interacts with newly synthesized glycoproteins by binding to Glc1Man9GlcNAc2 oligosaccharides as… Continue reading Contributions of the Lectin and Polypeptide Binding Sites of Calreticulin to Its Chaperone Functions in Vitro and in Cells
2017 / The Journal of Biological Chemistry
Heme nitric oxide/oxygen (H-NOX)-binding proteins act as nitric oxide (NO) sensors among various bacterial species. In several cases, they act… Continue reading Heme-independent Redox Sensing by the Heme-Nitric Oxide/Oxygen-binding Protein (H-NOX) from Vibrio cholerae
2016 / The Journal of Biological Chemistry
Intervention into amyloid deposition with anti-amyloid agents like the polyphenol epigallocatechin-3-gallate (EGCG) is emerging as an experimental secondary treatment strategy… Continue reading Aggregation of Full-length Immunoglobulin Light Chains from Systemic Light Chain Amyloidosis (AL) Patients Is Remodeled by Epigallocatechin-3-gallate
2016 / The Journal of Biological Chemistry
Capreomycin is a potent ribosome-targeting antibiotic that is an essential component of current antituberculosis treatments, particularly in the case of… Continue reading A Novel Motif for S-Adenosyl-L-methionine Binding by the Ribosomal RNA Methyltransferase TlyA from Mycobacterium tuberculosis
2016 / The Journal of Biological Chemistry
The LasR regulator protein functions at the top of the Pseudomonas aeruginosaquorum-sensing hierarchy and is implicated in promoting bacterial virulence. Of… Continue reading Molecular Insights into the Impact of Oxidative Stress on the Quorum-Sensing Regulator Protein LasR
2016 / The Journal of Biological Chemistry
ABC transporters are polytopic membrane proteins that utilize ATP binding and hydrolysis to facilitate transport across biological membranes. Forty-eight human… Continue reading Stabilization of Nucleotide Binding Domain Dimers Rescues ABCC6 Mutants Associated with Pseudoxanthoma Elasticum
2017 / The Journal of Biological Chemistry
Members of the gammaproteobacterial Photorhabdus genus share mutualistic relationships with Heterorhabditis nematodes, and the pairs infect a wide swath of insect larvae. Photorhabdus species produce a… Continue reading Stilbene epoxidation and detoxification in a Photorhabdus luminescens-nematode symbiosis
2017 / The Journal of Biological Chemistry
The kinase interaction motif (KIM) family of protein tyrosine phosphatases (PTPs) includes hematopoietic protein tyrosine phosphatase (HePTP), striatal-enriched protein tyrosine… Continue reading The KIM-family Protein Tyrosine Phosphatases use distinct reversible oxidation intermediates: intramolecular or intermolecular disulfide bond formation
2016 / The Journal of Biological Chemistry
The C-terminal domain (CTD) of RNA polymerase II in eukaryotes is comprised of tandemly repeating units of a conserved seven-amino… Continue reading DNA Instability Maintains the Repeat Length of the Yeast RNA Polymerase II C-terminal Domain
2017 / Protein Expression and Purification
A mutation (D187N/Y) in human plasma gelsolin (GSN) leads to the generation of an 8 kDa GSN fragment (8 kDa-GSN), and consequently… Continue reading Expression, purification, and characterization of recombinant 8 kDa gelsolin fragment
2017 / Archives of Biochemistry and Biophysics
In obligate dimeric proteins of hyperthermophilic origin the question whether the native dimer is obtained by association of folded monomers… Continue reading Hyperthermophilic L-asparaginase bypasses monomeric intermediates during folding to retain cooperativity and avoid amyloid assembly
2017 / Journal of Fluorine Chemistry
The evaluation of tyrosinase activity of CH, CH3F, CH4F, CH23F, CH25F, CH35F and CH2356F as well as of the interactions… Continue reading Biological interactions of fluorinated chalcones: Stimulation of tyrosinase activity and binding to bovine serum albumin
2017 / Acta Pharmaceutica Sinica B
Six new indole alkaloid sulfonic acids (1–6), together with two analogues (7 and 8) that were previously reported as synthetic products, were… Continue reading Indole alkaloid sulfonic acids from an aqueous extract of Isatis indigotica roots and their antiviral activity
2017 / Vaccine
The outer-domain core of gp120 may serve as a better HIV vaccine immunogen than the full-length gp120 because of its… Continue reading Tryptophan 375 stabilizes the outer-domain core of gp120 for HIV vaccine immunogen design
2017 / International Journal of Antimicrobial Agents
Andrias davidianus, the Chinese giant salamander, has been used in traditional Chinese medicine for many decades. However, no antimicrobial peptides… Continue reading Antimicrobial peptide from mucus of Andrias davidianus: screening and purification by magnetic cell membrane separation technique
