Found 9617 Results / Page 328 of 481
2014 / PLoS ONE
Oversulfated chondroitin sulfate (OSCS), a member of the glycosaminoglycan (GAG) family, was a contaminant in heparin that was linked to… Continue reading Oversulfated Chondroitin Sulfate Binds to Chemokines and Inhibits Stromal Cell-Derived Factor-1 Mediated Signaling in Activated T Cells
2014 / PLoS ONE
The translationally-controlled tumor protein (TCTP) is a highly conserved, ubiquitously expressed, abundant protein that is broadly distributed among eukaryotes. Its biological function spans… Continue reading Ligand Binding Reveals a Role for Heme in Translationally-Controlled Tumor Protein Dimerization
2012 / PLoS ONE
Subunit vaccines are significantly more expensive to produce than traditional vaccines because they are based primarily on recombinant proteins that… Continue reading Algae-Produced Pfs25 Elicits Antibodies That Inhibit Malaria Transmission
2007 / PLoS ONE
This study examines the surface activity and resistance to phospholipase degradation of a fully-synthetic lung surfactant containing a novel diether… Continue reading Dynamic Surface Activity of a Fully Synthetic Phospholipase-Resistant Lipid/Peptide Lung Surfactant
2016 / PLoS ONE
The transitioning of the ectodomain of gp41 from a pre-hairpin to a six-helix bundle conformation is a crucial aspect of… Continue reading Insights into the Conformation of the Membrane Proximal Regions Critical to the Trimerization of the HIV-1 gp41 Ectodomain Bound to Dodecyl Phosphocholine Micelles
2014 / PLoS ONE
Bdellovibrio bacteriovorus is a δ-proteobacterium that preys upon Salmonella spp., E. coli, and other Gram-negative bacteria. Bdellovibrio can grow axenically (host-independent, HI, rare and mutation-driven)… Continue reading The Lifestyle Switch Protein Bd0108 of Bdellovibrio bacteriovorus Is an Intrinsically Disordered Protein
2010 / PLoS ONE
Many Gram-positive bacteria produce pore-forming exotoxins that contain a highly conserved, 12-residue domain (ECTGLAWEWWRT) that binds cholesterol. This domain is… Continue reading Oxpholipin 11D: An Anti-Inflammatory Peptide That Binds Cholesterol and Oxidized Phospholipids
2015 / PLoS ONE
We previously identified several peptide sequences that mimicked the terminal sugars of complex glycans. Using plant lectins as analogs of… Continue reading A Peptide Mimetic of 5-Acetylneuraminic Acid-Galactose Binds with High Avidity to Siglecs and NKG2D
2014 / PLoS ONE
We previously reported a series of antibodies, in fragment antigen binding domain (Fab) formats, selected from a human non-immune phage… Continue reading Binding of HIV-1 gp41-Directed Neutralizing and Non-Neutralizing Fragment Antibody Binding Domain (Fab) and Single Chain Variable Fragment (ScFv) Antibodies to the Ectodomain of gp41 in the Pre-Hairpin and Six-Helix Bundle Conformations
2011 / PLoS ONE
Cholera toxin (CT) travels as an intact AB5 protein toxin from the cell surface to the endoplasmic reticulum (ER) of an… Continue reading A Therapeutic Chemical Chaperone Inhibits Cholera Intoxication and Unfolding/Translocation of the Cholera Toxin A1 Subunit
2008 / PLoS ONE
Synthetic mosquito oviposition attractants are sorely needed for surveillance and control programs for Culex species, which are major vectors of pathogens causing… Continue reading Reverse and Conventional Chemical Ecology Approaches for the Development of Oviposition Attractants for CulexMosquitoes
2012 / PLoS ONE
Legionella pneumophila is a pathogenic bacterium that can cause Legionnaires’ disease and other non-pneumonic infections in humans. This bacterium produces a… Continue reading Phenylalanine Hydroxylase from Legionella pneumophila Is a Thermostable Enzyme with a Major Functional Role in Pyomelanin Synthesis
2015 / PLoS ONE
Recent studies introduced two experimental protocols for converting full-length recombinant prion protein (rPrP) purified from E.coli into the infectious prion state (PrPSc)… Continue reading Contrasting Effects of Two Lipid Cofactors of Prion Replication on the Conformation of the Prion Protein
2013 / PLoS ONE
In the lipocalin family, the conserved interaction between the main α-helix and the β-strand H is an ideal model to… Continue reading Effect of Short- and Long-Range Interactions on Trp Rotamer Populations Determined by Site-Directed Tryptophan Fluorescence of Tear Lipocalin
2013 / PLoS ONE
Chlamydia trachomatis replicates in a parasitophorous membrane-bound compartment called an inclusion. The inclusions corrupt host vesicle trafficking networks to avoid the degradative… Continue reading Two Coiled-Coil Domains of Chlamydia trachomatis IncA Affect Membrane Fusion Events during Infection
2013 / PLoS ONE
Two yeast manganese superoxide dismutases (MnSOD), one from Saccharomyces cerevisiae mitochondria (ScMnSOD) and the other from Candida albicans cytosol (CaMnSODc), have most biochemical and… Continue reading Tetramerization Reinforces the Dimer Interface of MnSOD
2012 / PLoS ONE
Enrichment of four tandem repeats of guanine (G) rich and cytosine (C) rich sequences in functionally important regions of human… Continue reading Intramolecular Folding in Human ILPR Fragment with Three C-Rich Repeats
2011 / PLoS ONE
Myocilin is an eye protein found in the trabecular extracellular matrix (TEM), within the anatomic region that controls fluid flow.… Continue reading Biophysical Characterization of the Olfactomedin Domain of Myocilin, an Extracellular Matrix Protein Implicated in Inherited Forms of Glaucoma
2010 / PLoS ONE
Amino acid replacements at dozens of positions in the dimeric protein human, Cu,Zn superoxide dismutase (SOD1) can cause amyotrophic lateral… Continue reading Metal-Free ALS Variants of Dimeric Human Cu,Zn-Superoxide Dismutase Have Enhanced Populations of Monomeric Species
2009 / PLoS Pathogens
Uncomplicated infections of the urinary tract, caused by uropathogenic Escherichia coli, are among the most common diseases requiring medical intervention. A… Continue reading Mucosal Immunization with Iron Receptor Antigens Protects against Urinary Tract Infection
