Found 9617 Results / Page 329 of 481
2010 / PLoS ONE
Griffithsin, a 121-residue protein isolated from a red algal Griffithsia sp., binds high mannose N-linked glycans of virus surface glycoproteins with… Continue reading Grifonin-1: A Small HIV-1 Entry Inhibitor Derived from the Algal Lectin, Griffithsin
2007 / PLoS ONE
The pathogenic spirochete Leptospira interrogans disseminates throughout its hosts via the bloodstream, then invades and colonizes a variety of host tissues. Infectious… Continue reading Leptospira interrogans Endostatin-Like Outer Membrane Proteins Bind Host Fibronectin, Laminin and Regulators of Complement
2017 / PLoS Pathogens
Despite the wide use of Caenorhabditis elegans as a model organism, the first virus naturally infecting this organism was not discovered until… Continue reading Structure of a pentameric virion-associated fiber with a potential role in Orsay virus entry to host cells
2016 / PLoS Genetics
Guanine (G)-rich DNA readily forms four-stranded quadruplexes in vitro, but evidence for their participation in genome regulation is limited. We have… Continue reading A Parallel G Quadruplex-Binding Protein Regulates the Boundaries of DNA Elimination Events of Tetrahymena thermophila
2016 / PLoS ONE
The extrinsic apoptotic pathway is initiated by binding of a Fas ligand to the ectodomain of the surface death receptor… Continue reading Identification of the Calmodulin-Binding Domains of Fas Death Receptor
2014 / PLoS ONE
Tyrosinase (TYR) catalyzes the rate-limiting, first step in melanin production and its gene (TYR) is mutated in many cases of… Continue reading Albinism-Causing Mutations in Recombinant Human Tyrosinase Alter Intrinsic Enzymatic Activity
2012 / PLoS ONE
We have engineered pH sensitive binding proteins for the Fc portion of human immunoglobulin G (hIgG) (hFc) using two different… Continue reading Design of pH Sensitive Binding Proteins from the Hyperthermophilic Sso7d Scaffold
2012 / PLoS Pathogens
The type VI secretion system (T6SS) has emerged as an important mediator of interbacterial interactions. A T6SS from Pseudomonas aeruginosa targets at… Continue reading Structural Basis for Type VI Secretion Effector Recognition by a Cognate Immunity Protein
2011 / PLoS Pathogens
Sequencing of invasive strains of group A streptococci (GAS) has revealed a diverse array of single nucleotide polymorphisms in the… Continue reading Distinct Single Amino Acid Replacements in the Control of Virulence Regulator Protein Differentially Impact Streptococcal Pathogenesis
2009 / PLoS ONE
New insecticides are urgently needed because resistance to current insecticides allows resurgence of disease-transmitting mosquitoes while concerns for human toxicity… Continue reading Selective and Irreversible Inhibitors of Mosquito Acetylcholinesterases for Controlling Malaria and Other Mosquito-Borne Diseases
2009 / PLoS ONE
Mutations in the gene encoding Cu-Zn superoxide dismutase (SOD1) are one of the causes of familial amyotrophic lateral sclerosis (FALS).… Continue reading Loss of Metal Ions, Disulfide Reduction and Mutations Related to Familial ALS Promote Formation of Amyloid-Like Aggregates from Superoxide Dismutase
2008 / PLoS Genetics
At the interface between T cell and antigen-presenting cell (APC), peptide antigen presented by MHC (pMHC) binds to the T… Continue reading Surface-Anchored Monomeric Agonist pMHCs Alone Trigger TCR with High Sensitivity
2010 / PLoS ONE
Many neurodegenerative diseases are characterized by the conformational change of normal self-proteins into amyloidogenic, pathological conformers, which share structural properties… Continue reading Immunomodulation Targeting Abnormal Protein Conformation Reduces Pathology in a Mouse Model of Alzheimer’s Disease
2016 / PLoS Pathogens
Natural transformation, or competence, is an ability inherent to bacteria for the uptake of extracellular DNA. This process is central… Continue reading Pheromone Recognition and Selectivity by ComR Proteins among Streptococcus Species
2015 / PLoS ONE
MicroRNAs (miRNAs) are critical post-transcriptional regulators of gene expression. Their precursors have a globally A-form helical geometry, which prevents most… Continue reading Helical Defects in MicroRNA Influence Protein Binding by TAR RNA Binding Protein
2014 / PLoS ONE
SUMO-binding proteins interact with SUMO modified proteins to mediate a wide range of functional consequences. Here, we report the identification… Continue reading Characterization of the SUMO-Binding Activity of the Myeloproliferative and Mental Retardation (MYM)-Type Zinc Fingers in ZNF261 and ZNF198
2014 / PLoS ONE
A switch in the conformational properties of α-synuclein (αS) is hypothesized to be a key step in the pathogenic mechanism… Continue reading N-Alpha-Acetylation of α-Synuclein Increases Its Helical Folding Propensity, GM1 Binding Specificity and Resistance to Aggregation
2013 / PLoS ONE
Ceriporiopsis subvermispora oxalate oxidase (CsOxOx) is the first bicupin enzyme identified that catalyzes manganese-dependent oxidation of oxalate. In previous work, we… Continue reading Kinetic and Spectroscopic Studies of Bicupin Oxalate Oxidase and Putative Active Site Mutants
2010 / PLoS Pathogens
Since the advent of genome-wide small interfering RNA screening, large numbers of cellular cofactors important for viral infection have been… Continue reading A Major Determinant of Cyclophilin Dependence and Cyclosporine Susceptibility of Hepatitis C Virus Identified by a Genetic Approach
2012 / PLoS ONE
Neuropilin (Nrp) receptors function as essential cell surface receptors for the Vascular Endothelial Growth Factor (VEGF) family of proangiogenic cytokines… Continue reading Mechanism of Selective VEGF-A Binding by Neuropilin-1 Reveals a Basis for Specific Ligand Inhibition
