Found 9617 Results / Page 330 of 481
2012 / PLoS ONE
Significant efforts to develop both laboratory and field-based detection assays for an array of potential biological threats started well before… Continue reading Rugged Single Domain Antibody Detection Elements for Bacillus anthracis Spores and Vegetative Cells
2011 / PLoS ONE
Regulation of protein activity is central to the complexity of life. The ability to regulate protein activity through exogenously added… Continue reading In Vitro Recombination of Non-Homologous Genes Can Result in Gene Fusions that Confer a Switching Phenotype to Cells
2011 / PLoS ONE
CaM-KIIN has evolved to inhibit stimulated and autonomous activity of the Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) efficiently, selectively, and… Continue reading Improving a Natural CaMKII Inhibitor by Random and Rational Design
2011 / PLoS ONE
The precise mechanism by which glucocorticoid receptor (GR) regulates the transcription of its target genes is largely unknown. This is,… Continue reading TBP Binding-Induced Folding of the Glucocorticoid Receptor AF1 Domain Facilitates Its Interaction with Steroid Receptor Coactivator-1
2009 / PLoS ONE
Falcipain-2, a papain family cysteine protease of the malaria parasite Plasmodium falciparum, plays a key role in parasite hydrolysis of hemoglobin… Continue reading Regulatory Elements within the Prodomain of Falcipain-2, a Cysteine Protease of the Malaria Parasite Plasmodium falciparum
2009 / PLoS ONE
The exocyst is a large hetero-octomeric protein complex required for regulating the targeting and fusion of secretory vesicles to the… Continue reading Conservation of Helical Bundle Structure between the Exocyst Subunits
2008 / PLoS ONE
The red imported fire ant (RIFA), Solenopsis invicta, is an invasive species, accidentally introduced in the United States that can cause… Continue reading GP-9s Are Ubiquitous Proteins Unlikely Involved in Olfactory Mediation of Social Organization in the Red Imported Fire Ant, Solenopsis invicta
2014 / PLoS Pathogens
The process of antibody ontogeny typically improves affinity, on-rate, and thermostability, narrows polyspecificity, and rigidifies the combining site to the… Continue reading Ontogeny of Recognition Specificity and Functionality for the Broadly Neutralizing Anti-HIV Antibody 4E10
2016 / PLoS ONE
Mitochondrial transcription factor A (TFAM) had previously been shown to act as a damage associated molecular pattern with the ability… Continue reading Mechanism of Mitochondrial Transcription Factor A Attenuation of CpG-Induced Antibody Production
2015 / PLoS ONE
DksA controls transcription of genes associated with diverse stress responses, such as amino acid and carbon starvation, oxidative stress, and… Continue reading pH Dependence of the Stress Regulator DksA
2014 / PLoS ONE
Proteins that are post-translationally adducted with 2-(ω-carboxyethyl)pyrrole (CEP) have been proposed to play a pathogenic role in age-related macular degeneration,… Continue reading Lack of Involvement of CEP Adducts in TLR Activation and in Angiogenesis
2014 / PLoS ONE
There is ongoing interest to develop high affinity, thermal stable recognition elements to replace conventional antibodies in biothreat detection assays.… Continue reading Development and Evaluation of Single Domain Antibodies for Vaccinia and the L1 Antigen
2014 / PLoS ONE
Mutations in the ABCC6 ABC-transporter are causative of pseudoxanthoma elasticum (PXE). The loss of functional ABCC6 protein in the basolateral… Continue reading Regulation of ABCC6 Trafficking and Stability by a Conserved C-terminal PDZ-Like Sequence
2014 / PLoS ONE
The creation of a synthetic microbe that can harvest energy from sunlight to drive its metabolic processes is an attractive… Continue reading A Tale of Two Reductases: Extending the Bacteriochlorophyll Biosynthetic Pathway in E. coli
2014 / PLoS ONE
Single domain antibodies are the small recombinant variable domains derived from camelid heavy-chain-only antibodies. They are renowned for their stability,… Continue reading Evaluation of Disulfide Bond Position to Enhance the Thermal Stability of a Highly Stable Single Domain Antibody
2013 / PLoS ONE
Single domain antibodies (sdAbs) are the recombinantly-expressed variable domain from camelid (or shark) heavy chain only antibodies and provide rugged… Continue reading Contributions of the Complementarity Determining Regions to the Thermal Stability of a Single-Domain Antibody
2016 / PLoS Genetics
Genetic leukoencephalopathies (gLEs) are a group of heterogeneous disorders with white matter abnormalities affecting the central nervous system (CNS). The… Continue reading A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects
2011 / PLoS Genetics
The flexibility in the structure of calmodulin (CaM) allows its binding to over 300 target proteins in the cell. To… Continue reading The Effect of Macromolecular Crowding, Ionic Strength and Calcium Binding on Calmodulin Dynamics
2015 / PLoS ONE
A central event in Alzheimer’s disease is the accumulation of amyloid β (Aβ) peptides generated by the proteolytic cleavage of… Continue reading Amyloid Precursor Protein Translation Is Regulated by a 3’UTR Guanine Quadruplex
2014 / PLoS ONE
β-Lactamases are the major reason β-lactam resistance is seen in Gram-negative bacteria. To combat this resistance mechanism, β-lactamase inhibitors are… Continue reading Penam Sulfones and β-Lactamase Inhibition: SA2-13 and the Importance of the C2 Side Chain Length and Composition
