Found 9617 Results / Page 331 of 481
2004 / PLoS Genetics
In nature, Escherichia coli are exposed to harsh and non-ideal growth environments—nutrients may be limiting, and cells are often challenged by oxidative… Continue reading Oxidative Stress Inactivates Cobalamin-Independent Methionine Synthase (MetE) in Escherichia coli
2014 / PLoS ONE
Artificial enzymes hold the potential to catalyze valuable reactions not observed in nature. One approach to build artificial enzymes introduces… Continue reading Thermostable Artificial Enzyme Isolated by In Vitro Selection
2014 / PLoS ONE
Pathogen reduction is a viable approach to ensure the continued safety of the blood supply against emerging pathogens. However, the… Continue reading Pathogen Reduction in Human Plasma Using an Ultrashort Pulsed Laser
2013 / PLoS ONE
Cytoplasmic dynein and dynactin participate in retrograde transport of organelles, checkpoint signaling and cell division. The principal subunits that mediate… Continue reading Dynein and Dynactin Leverage Their Bivalent Character to Form a High-Affinity Interaction
2015 / PLoS ONE
The mammalian high mobility group protein AT-hook 2 (HMGA2) is a chromosomal architectural transcription factor involved in cell transformation and… Continue reading The Dimerization State of the Mammalian High Mobility Group Protein AT-Hook 2 (HMGA2)
2012 / PLoS Pathogens
Staphylococcus aureus is an opportunistic pathogen that colonizes the skin and mucosal surfaces of mammals. Persistent staphylococcal infections often involve surface-associated… Continue reading Functional Amyloids Composed of Phenol Soluble Modulins Stabilize Staphylococcus aureus Biofilms
2011 / PLoS Pathogens
TRIM proteins play important roles in the innate immune defense against retroviral infection, including human immunodeficiency virus type-1 (HIV-1). Rhesus… Continue reading Rhesus TRIM5α Disrupts the HIV-1 Capsid at the InterHexamer Interfaces
2016 / PLoS ONE
Sirtuins are emerging as the key regulators of metabolism and aging, and their potential activators and inhibitors are being explored… Continue reading Role of the Substrate Specificity-Defining Residues of Human SIRT5 in Modulating the Structural Stability and Inhibitory Features of the Enzyme
2014 / PLoS ONE
In response to pervasive sexual selection, protein sex pheromones often display rapid mutation and accelerated evolution of corresponding gene sequences.… Continue reading Structural Insights into the Evolution of a Sexy Protein: Novel Topology and Restricted Backbone Flexibility in a Hypervariable Pheromone from the Red-Legged Salamander, Plethodon shermani
2013 / PLoS ONE
MtDef4 is a 47-amino acid cysteine-rich evolutionary conserved defensin from a model legume Medicago truncatula. It is an apoplast-localized plant defense… Continue reading Structural and Functional Studies of a Phosphatidic Acid-Binding Antifungal Plant Defensin MtDef4: Identification of an RGFRRR Motif Governing Fungal Cell Entry
2013 / PLoS ONE
Aquaporin 0 (AQP0) formerly known as membrane intrinsic protein (MIP), is expressed exclusively in the lens during terminal differentiation of… Continue reading Thermal Stress Induced Aggregation of Aquaporin 0 (AQP0) and Protection by α-Crystallin via Its Chaperone Function
2012 / PLoS ONE
The deposition and oligomerization of amyloid β (Aβ) peptide plays a key role in the pathogenesis of Alzheimer’s disease (AD).… Continue reading The Influence of Spin-Labeled Fluorene Compounds on the Assembly and Toxicity of the Aβ Peptide
2011 / PLoS Pathogens
Facultative bacterial pathogens must adapt to multiple stimuli to persist in the environment or establish infection within a host. Temperature… Continue reading A Protein Thermometer Controls Temperature-Dependent Transcription of Flagellar Motility Genes in Listeria monocytogenes
2013 / PLoS ONE
The C-terminal V5 domain is one of the most variable domains in Protein Kinase C isoforms (PKCs). V5 confers isoform… Continue reading The C-Terminal V5 Domain of Protein Kinase Cα Is Intrinsically Disordered, with Propensity to Associate with a Membrane Mimetic
2015 / PLoS ONE
The membrane proximal external region (MPER) of the gp41 subunit of the HIV-1 envelope glycoprotein (Env) contains determinants for broadly… Continue reading Immunogens Modeling a Fusion-Intermediate Conformation of gp41 Elicit Antibodies to the Membrane Proximal External Region of the HIV Envelope Glycoprotein
2011 / PLoS ONE
Amyloid-β (Aβ) peptide aggregation is known to play a central role in the etiology of Alzheimer’s disease (AD). Among various… Continue reading Non-Esterified Fatty Acids Generate Distinct Low-Molecular Weight Amyloid-β (Aβ42) Oligomers along Pathway Different from Fibril Formation
2012 / PLoS ONE
Serine proteinase inhibitors of the serpin family are well known as negative regulators of hemostasis, thrombolysis and innate immune responses.… Continue reading Biochemical Characterization of Anopheles gambiae SRPN6, a Malaria Parasite Invasion Marker in Mosquitoes
2012 / PLoS ONE
Cellulase enzymes deconstruct cellulose to glucose, and are often comprised of glycosylated linkers connecting glycoside hydrolases (GHs) to carbohydrate-binding modules… Continue reading Cellulase Linkers Are Optimized Based on Domain Type and Function: Insights from Sequence Analysis, Biophysical Measurements, and Molecular Simulation
2011 / PLoS ONE
AB toxins such as ricin and cholera toxin (CT) consist of an enzymatic A domain and a receptor-binding B domain.… Continue reading Modulation of Toxin Stability by 4-Phenylbutyric Acid and Negatively Charged Phospholipids
2012 / PLoS ONE
As a small stress response protein, human αB crystallin, detects protein destabilization that can alter structure and function to cause… Continue reading Hemoglobin Interactions with αB Crystallin: A Direct Test of Sensitivity to Protein Instability
