Found 9617 Results / Page 332 of 481
2015 / PLoS ONE
The epidermal growth factor receptor (EGFR) is overexpressed in multiple carcinomas and is the focus of a variety of targeted… Continue reading Inhibiting EGFR Dimerization Using Triazolyl-Bridged Dimerization Arm Mimics
2014 / PLoS ONE
Mutations occur at four specific sites in the hTERT promoter in >75% of glioblastomas and melanomas, but the mechanism by… Continue reading An Improved Model for the hTERT Promoter Quadruplex
2016 / PLoS Pathogens
The Staphylococcus aureus manganese transporter protein MntC is under investigation as a component of a prophylactic S.aureus vaccine. Passive immunization with monoclonal antibodies mAB… Continue reading High Resolution Mapping of Bactericidal Monoclonal Antibody Binding Epitopes on Staphylococcus aureus Antigen MntC
2014 / PLoS Pathogens
Lyme disease spirochetes demonstrate strain- and species-specific differences in tissue tropism. For example, the three major Lyme disease spirochete species,… Continue reading Strain-Specific Variation of the Decorin-Binding Adhesin DbpA Influences the Tissue Tropism of the Lyme Disease Spirochete
2011 / PLoS ONE
Intrinsically disordered (ID) regions of proteins commonly exist within transcription factors, including the N-terminal domain (NTD) of steroid hormone receptors… Continue reading Binding-Folding Induced Regulation of AF1 Transactivation Domain of the Glucocorticoid Receptor by a Cofactor That Binds to Its DNA Binding Domain
2015 / PLoS ONE
Recent studies have highlighted the overexpression of mucin 1 (MUC1) in various epithelial carcinomas and its role in tumorigenesis. These… Continue reading MUC1-Targeted Cancer Cell Photothermal Ablation Using Bioinspired Gold Nanorods
2013 / PLoS ONE
Prion diseases are fatal neurodegenerative disorders characterized by misfolding of the cellular prion protein (PrPc) into the disease-associated isoform (PrPSc)… Continue reading Introducing a Rigid Loop Structure from Deer into Mouse Prion Protein Increases Its Propensity for Misfolding In Vitro
2013 / PLoS ONE
The fibrillation of Serum Amyloid A (SAA) – a major acute phase protein – is believed to play a role… Continue reading Characterization of the Oligomerization and Aggregation of Human Serum Amyloid A
2011 / PLoS ONE
Cockroach allergy is strongly associated with asthma, and involves the production of IgE antibodies against inhaled allergens. Reports of conformational… Continue reading Mechanisms of Allergen-Antibody Interaction of Cockroach Allergen Bla g 2 with Monoclonal Antibodies That Inhibit IgE Antibody Binding
2011 / PLoS ONE
The eye lens is composed of fiber cells that are filled with α-, β- and γ-crystallins. The primary function of… Continue reading αA-Crystallin Peptide 66SDRDKFVIFLDVKHF80 Accumulating in Aging Lens Impairs the Function of α-Crystallin and Induces Lens Protein Aggregation
2014 / PLoS Pathogens
To generate a cytopathic effect, the catalytic A1 subunit of cholera toxin (CT) must be separated from the rest of… Continue reading Substrate-Induced Unfolding of Protein Disulfide Isomerase Displaces the Cholera Toxin A1 Subunit from Its Holotoxin
2012 / PLoS ONE
A substitution mutation in human αA-crystallin (αAG98R) is associated with autosomal dominant cataract. The recombinant mutant αAG98R protein exhibits altered… Continue reading αA-Crystallin–Derived Mini-Chaperone Modulates Stability and Function of Cataract Causing αAG98R-Crystallin
2010 / PLoS ONE
Pigment epithelium-derived factor (PEDF) is widely known for its neurotrophic and antiangiogenic functions. Efficacy studies of PEDF in animal models… Continue reading Codon Preference Optimization Increases Heterologous PEDF Expression
2010 / PLoS ONE
In the face of impending influenza pandemic, a rapid vaccine production and mass vaccination is the most effective approach to… Continue reading Properly Folded Bacterially Expressed H1N1 Hemagglutinin Globular Head and Ectodomain Vaccines Protect Ferrets against H1N1 Pandemic Influenza Virus
2017 / International Journal of Peptide Research and Therapeutics
Bioactive peptides are defined as protein-based components having nutritional value and have proved roles important for the human health. In… Continue reading Kinetics Study of Protein Hydrolysis and Inhibition of Angiotensin Converting Enzyme by Peptides Hydrolysate Extracted from Walnut
2014 / PLoS ONE
The aggregation of amyloid-β (Aβ) peptide and its deposition in parts of the brain form the central processes in the… Continue reading Self-Propagative Replication of Aβ Oligomers Suggests Potential Transmissibility in Alzheimer Disease
2015 / PLoS Pathogens
The spread of β-lactamases that hydrolyze penicillins, cephalosporins and carbapenems among Gram-negative bacteria has limited options for treating bacterial infections.… Continue reading Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability
2014 / PLoS ONE
In this paper, we demonstrate that single enzyme molecules of β-galactosidase interconvert between different activity states upon exposure to short… Continue reading Observing Single Enzyme Molecules Interconvert between Activity States upon Heating
2010 / PLoS ONE
Botulinum neurotoxins (BoNT) are the most potent of all toxins. The 50 kDa N-terminal endopeptidase catalytic light chain (LC) of… Continue reading Light Chain Separated from the Rest of the Type A Botulinum Neurotoxin Molecule Is the Most Catalytically Active Form
2015 / PLoS ONE
Ledipasvir, a direct acting antiviral agent (DAA) targeting the Hepatitis C Virus NS5A protein, exhibits picomolar activity in replicon cells.… Continue reading Direct Binding of Ledipasvir to HCV NS5A: Mechanism of Resistance to an HCV Antiviral Agent
