Found 9617 Results / Page 335 of 481
2017 / PNAS
Paleotemperatures inferred from the isotopic compositions (δ18O and δ30Si) of marine cherts suggest that Earth’s oceans cooled from 70 ±… Continue reading Reconstructed ancestral enzymes suggest long-term cooling of Earth’s photic zone since the Archean
2017 / Biochimica et Biophysica Acta (BBA) - Biomembranes
Apolipophorin III (apoLp-III) is an insect apolipoprotein (18 kDa) that comprises a single five-helix bundle domain. In contrast, human apolipoprotein A-I… Continue reading Transfer of C-terminal residues of human apolipoprotein A-I to insect apolipophorin III creates a two-domain chimeric protein with enhanced lipid binding activity
2017 / Food Chemistry
Temperature sensitivity of bovine milk beta-lactoglobulin (BLG) was assessed in the presence/absence of non-reducing sugars (sucrose and trehalose) and polyols… Continue reading Stabilization of beta-lactoglobulin by polyols and sugars against temperature-induced denaturation involves diverse and specific structural regions of the protein
2017 / Cell
The phosphorylation of agonist-occupied G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) functions to turn off G-protein signaling and turn on… Continue reading Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5
2007 / Biophysical Chemistry
The glucocorticoid receptor (GR) is involved in the transcriptional regulation of genes associated with inflammation, glucose homeostasis, and bone turnover… Continue reading Agonist versus antagonist induce distinct thermodynamic modes of co-factor binding to the glucocorticoid receptor
2015 / Molecular Immunology
The complement system plays a central role in a number of human inflammatory diseases, and there is a significant need… Continue reading Identification of peptidic inhibitors of the alternative complement pathway based on Staphylococcus aureus SCIN proteins
2017 / European Journal of Medicinal Chemistry
Glucagon-like peptide (GLP-1) is an endogenous hormone that induces insulin secretion from pancreatic islets and modified forms are used to… Continue reading Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling
2013 / Biophysical Chemistry
The Escherichia coli protein RecA is responsible for catalysis of the strand transfer reaction used in DNA repair and recombination. Previous studies… Continue reading The effects of buffers and pH on the thermal stability, unfolding and substrate binding of RecA ☆
2015 / Bioorganic & Medicinal Chemistry
N5-carboxy-amino-imidazole ribonucleotide (N5-CAIR) mutase (PurE), a bacterial enzyme in the de novo purine biosynthetic pathway, has been suggested to be a target… Continue reading Identification of Bacillus anthracis PurE inhibitors with antimicrobial activity
2012 / Protein Expression and Purification
Biophysical and structural characterization of G protein-coupled receptors (GPCRs) has been limited due to difficulties in expression, purification, and vitro stability of… Continue reading An expression and purification system for the biosynthesis of adenosine receptor peptides for biophysical and structural characterization
2007 / Vaccine
Synthetic peptides derived from the G-H loop of the foot and mouth disease virus (FMDV) capsid protein VP1 are relatively… Continue reading Non-toxic Pseudomonas aeruginosa exotoxin A expressing the FMDV VP1 G-H loop for mucosal vaccination of swine against foot and mouth disease virus
2009 / Vaccine
The membrane proximal region (MPR) of HIV-1 gp41 is a desirable target for development of a vaccine that elicits neutralizing… Continue reading Role of lipid structure in the humoral immune response in mice to covalent lipid–peptides from the membrane proximal region of HIV-1 gp41
2017 / Phytochemistry
Thirteen previously undescribed 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones named tetrahydrochromone A–M, together with nine known ones, were isolated from artificial agarwood (induced by holing)… Continue reading 5,6,7,8-Tetrahydro-2-(2-phenylethyl)chromones from artificial agarwood of Aquilaria sinensis and their inhibitory activity against acetylcholinesterase
2017 / European Journal of Medicinal Chemistry
Increasing evidence is accumulating, showing that neurodegenerative disorders are somehow associated with the toxicity of amyloid aggregates, metal ion dyshomeostasis… Continue reading Multitarget trehalose-carnosine conjugates inhibit Aβ aggregation, tune copper(II) activity and decrease acrolein toxicity
2006 / Journal of Pharmaceutical Sciences
This study focuses on the development and application of biophysical methodology to characterize conformations of Epogen® and Eprex®, the injectable… Continue reading Biophysical comparability of the same protein from different manufacturers: A case study using Epoetin alfa from Epogen® and Eprex®
2007 / Vaccine
Ricin is a potent toxin associated with bioterrorism for which no vaccine or specific countermeasures are currently available. A stable,… Continue reading Improved formulation of a recombinant ricin A-chain vaccine increases its stability and effective antigenicity
1999 / Journal of Biotechnology
The effect of polyethyleneimine (PEI), a cationic polymer, on protein stability was investigated. Shelf stability of lactate dehydrogenase, stored as… Continue reading Protein stabilising effect of polyethyleneimine
2010 / Journal of Pharmaceutical Sciences
Changes in protein–protein interactions, protein unfolding, and nonnative aggregation were assessed for a series of human IgG1 antibodies as a… Continue reading Comparative effects of pH and ionic strength on protein–protein interactions, unfolding, and aggregation for IgG1 antibodies
2012 / Molecular Pharmaceutics
Advancements towards an improved vaccine against Bacillus anthracis, the causative agent of anthrax, have focused on formulations composed of the… Continue reading Amphiphilic Polyanhydride Nanoparticles Stabilize Bacillus anthracis Protective Antigen
2012 / Nanoscale
We report the discovery of a DNA sequence that templates a highly stable fluorescent silver nanocluster. In contrast to other… Continue reading A DNA-templated fluorescent silver nanocluster with enhanced stability
