Found 9617 Results / Page 336 of 481
2011 / Langmuir
The synthesis, characterization, and evaluation of a novel polymer–protein conjugate are reported here. The covalent conjugation of high-molecular weight poly(acrylic… Continue reading Protein Polymer Conjugates: Improving the Stability of Hemoglobin with Poly(acrylic acid)
2009 / Biochemistry
Protein therapeutics made up of artificially combined proteins or protein domains, so called fusion proteins, are a novel and growing… Continue reading Physical Instability of a Therapeutic Fc Fusion Protein: Domain Contributions to Conformational and Colloidal Stability
2002 / Journal of Pharmaceutical Sciences
A method is described to identify small molecule ligands that stabilize proteins. The procedure is based on the hypothesis that… Continue reading Stabilization of proteins by low molecular weight multi-ions
2014 / European Journal of Pharmaceutical Sciences
Hemocyanin has been shown to have potential antiviral activity against herpes simplex virus type-1. However, current liquid formulations have short… Continue reading Formulation of abalone hemocyanin with high antiviral activity and stability
2011 / BMC Biotechnology
Camelids and sharks possess a unique subclass of antibodies comprised of only heavy chains. The antigen binding fragments of these… Continue reading Isolation of a Highly Thermal Stable Lama Single Domain Antibody Specific for Staphylococcus aureusEnterotoxin B
2001 / Bioscience, Biotechnology, and Biochemistry
Thermal stress was used to assess the stability of recombinant human erythropoietin (EPO) derived from Chinese hamster ovary cells. In… Continue reading Kinetic and Thermodynamic Analysis of Thermal Unfolding of Recombinant Erythropoietin
2007 / Biophysical Journal
Thermally induced aggregates of α-chymotrypsinogen A and bovine granulocyte-colony stimulating factor in acidic solutions were characterized by a combination of static… Continue reading Nonnative Protein Polymers: Structure, Morphology, and Relation to Nucleation and Growth ☆
2017 / Organic & Biomolecular Chemistry
Candida parapsilosis ATCC 7330, a rich source of highly stereospecific oxidoreductases, catalyzes oxidation-reduction of a plethora of compounds yielding industrially… Continue reading A carbonyl reductase from Candida parapsilosis ATCC 7330: Substrate selectivity and enantiospecificity
2017 / RSC Advances
Two types of Cu(II)–UMP-L coordination polymers, {[Cu2(UMP)2(bpda)2(H2O)3]·10H2O}n (1) and {[Cu2(UMP)2(bpe)2(H2O)2]·7H2O}n (2) (UMP = uridine 5′-monophosphate, bpda = 1,4-bis(4-pyridyl)-2,3-diaza-1,3-butadiene, bpe = 1,2-bis(4-pyridyl)ethylene), were… Continue reading Unusual crystal structure and chirality of uridine 5′-monophosphate coordination polymer
2017 / Biotechnology Journal
Production of hyperthermostable enzymes in mesophilic hosts frequently causes undesired aggregation of these proteins. During production of Pyrococcus furiosus endo-… Continue reading Chaotropic heat treatment resolves native-like aggregation of a heterologously produced hyperthermostable laminarinase
2017 / RSC Advances
The stabilization of a G-quadruplex structure in human telomeric DNA has become a promising strategy in the development of cancer… Continue reading Restriction of telomerase capping by short non-toxic peptides via arresting telomeric G-quadruplex
2017 / Peptide Science
he mutant huntingtin protein (mHtt) fragments with expanded polyglutamine sequence forms microscopically visible aggregates in neurons, a hallmark of Huntington’s… Continue reading Inhibition of polyglutamine aggregation by SIMILAR huntingtin N-terminal sequences: Prospective molecules for preclinical evaluation in Huntington’s disease
2017 / New Journal of Chemistry
The Ebola virus Viral Protein 24 (VP24) inhibits interferon signaling through its interaction with the human protein Karyopherin, thus impairing… Continue reading Computer aided design and NMR characterization of an oligopeptide targeting Ebola virus VP24 protein
2017 / Metallomics
The DNA interstrand cross-links of the antitumor drug ({[cis-Pt(NH3)2Cl]2(4,4´-methylenedianiline)}2+ (1) play a prevalent role in its antitumor effects. Complex 1 forms in DNA… Continue reading Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(II) complex
2017 / Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Formation of amyloid fibrils is found to be a general tendency of many proteins. Investigating the kinetic mechanisms and structural… Continue reading Concentration dependent switch in the kinetic pathway of lysozyme fibrillation: Spectroscopic and microscopic analysis
2017 / European Journal of Medicinal Chemistry
Two mononuclear copper (II) terpyridine complexes namely, [Cu(Btptpy) (ClO4)](ClO4) 1, and [Cu(Bttpy) (ClO4)](ClO4) 2, (Btptpy (L1) = 4’-(Benzothiophene)-2,2’:6′,2″-terpyridine, Bttpy (L2) = 4’-(Benzylthiazolyl)-2,2’:6′,2″-terpyridine) have been synthesized and characterized. Single crystal X-ray… Continue reading Novel mononuclear Cu (II) terpyridine complexes: Impact of fused ring thiophene and thiazole head groups towards DNA/BSA interaction, cleavage and antiproliferative activity on HepG2 and triple negative CAL-51 cell line
2017 / International Journal of Biological Macromolecules
Calreticulin of Brugia malayi (BmCRT) play very important role in host-parasite interaction. In previous study it was found that BmCRT is responsible… Continue reading Monitoring thermal and chemical unfolding of Brugia malayi calreticulin using fluorescence and Circular Dichroism spectroscopy
2017 / Acta Biomaterialia
Herein, we report the oncolytic activity of cationic, one-dimensional (1D) fibril assemblies formed from coil-sheet poly(L-lysine)-block-poly(L-threonine) (PLL-b-PLT) block copolypeptides for… Continue reading One-dimensional Poly(L-Lysine)-block-Poly(L-Threonine) Assemblies Exhibit Potent Anticancer Activity by Enhancing Membranolysis
2017 / Biophysical Chemistry
The effect of oscillation induced by a frequency-dependent alternating current (AC) electric field to dissociate preformed amyloid fibrils has been… Continue reading Fibrillar disruption by AC electric field induced oscillation: A case study with human serum albumin
2017 / European Journal of Medicinal Chemistry
A series of 9-mer and 13-mer amide-bridged cyclic peptides derived from the linear prototype Ac-PKIIQSVGIS-Nle-K-Nle-NH2 (Toro et al. ChemBioChem2013) has been designed… Continue reading First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent in vitro antileishmanial activity#
