Found 9617 Results / Page 360 of 481
2017 / Biochemistry and Biophysics Reports
Inactivation of bacterial toxins for use in human vaccines traditionally is achieved by treatment with formaldehyde. In contrast, the bivalent… Continue reading Development of a subunit vaccine for prevention of Clostridium difficile associated diseases: biophysical characterization of toxoids A and B
2017 / International Journal of Biological Macromolecules
Peptidoglycan (PG) is the key component of the bacterial cell wall. The enzyme UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA) catalyzes the transfer… Continue reading UDP-N-Acetylglucosamine enolpyruvyl transferase (MurA) of Acinetobacter baumannii (AbMurA): Structural and functional properties
2017 / Journal of Inorganic Biochemistry
Triple-helical RNA are of interest because of possible biological roles as well as the potential therapeutic uses of these structures,… Continue reading Interaction of octahedral ruthenium(II) polypyridyl complex [Ru(bpy)2(PIP)]2 + with poly(U)•poly(A)*poly(U) triplex:increasing third-strand stabilization of the triplex without affecting the stability of the duplex
2017 / Journal of Pharmaceutical Sciences
This study explores the structural and functional changes associated with a low temperature thermal transition of two engineered bacterial uricase… Continue reading Impact of Mutations on the Higher Order Structure and Activity of a Recombinant Uricase
2017 / International Journal of Biological Macromolecules
γ-PGA-NHS ester, which was prepared using poly(γ-glutamic acid) (γ-PGA) and N-hydroxysuccinimide (NHS) as the raw materials, was synthesized to be… Continue reading The preparation of poly(γ-glutamic acid)-NHS ester as a natural cross-linking agent of collagen
2017 / Protein Expression and Purification
The second enzyme of the naphthalene degradation pathway in Pseudomonas putida G7 is NahB, a dehydrogenase that converts cis-1,2-dihydroxy-1,2-dihydronaphthalene to 1,2-dihydroxynaphthalene. We report… Continue reading A combined approach for enhancing the stability of recombinant cis-dihydrodiol naphthalene dehydrogenase from Pseudomonas putida G7 allowed for the structural and kinetic characterization of the enzyme
2017 / Acta Biomaterialia
Glucose-responsive system is one of important options for self-regulated insulin delivery to treat diabetes, which has become an issue of… Continue reading pH-sensitive peptide hydrogel for glucose-responsive insulin delivery
2017 / Analytical Biochemistry
The role of hemoglobin (Hb) redox forms in tissue and organ toxicities remain ambiguous despite the well-documented contribution of Hb… Continue reading Determination of extinction coefficients of human hemoglobin in various redox states
2017 / Journal of Chromatography A
Atropisomers are stereoisomers resulting from hindered bond rotation. From synthesis of pure atropisomers, characterization of their interconversion thermodynamics to investigation… Continue reading The role of chromatographic and chiroptical spectroscopic techniques and methodologies in support of drug discovery for atropisomeric drug inhibitors of Bruton’s tyrosine kinase
2017 / Journal of Pharmaceutical and Biomedical Analysis
The enantiomers of four chiral 3-aryl-substituted-γ-butyrolactones, key intermediates for the preparation of compounds of pharmaceutical interest, were successfully isolated by… Continue reading The Role of Chirality in a Set of Key Intermediates of Pharmaceutical Interest, 3-aryl-substituted-γ-butyrolactones, evidenced by Chiral HPLC Separation and by Chiroptical Spectroscopies
2017 / Protein Expression and Purification
Glycopeptides are an important class of antibiotics used in the treatment of several infections, including those ones caused by methicillin… Continue reading Cloning, expression, purification and biophysical analysis of two putative halogenases from the glycopeptide A47,934 gene cluster of Streptomyces toyocaensis
2017 / General and Comparative Endocrinology
In mammalian assay systems, calcitonin peptides of non-mammalian species exhibit stronger activity than those of mammals. Recently, comparative analyses of… Continue reading Platypus and opossum calcitonins exhibit strong activities, even though they belong to mammals
2017 / Food Hydrocolloids
The physicochemical characteristics, functional properties and amino acid composition of protein extracts from Mung bean were determined and analyzed for… Continue reading Extraction, physicochemical characteristics and functional properties of Mung bean protein
2016 / ACS Chemical Biology
The α-helical coiled coil is one of the best-studied protein-protein interaction motifs. As a result, sequence-to-structure relationships are available for… Continue reading N@a and N@d: Oligomer- and Partner-specification by Asparagine in Coiled-coil Interfaces
2016 / Protein Science
IgA1 proteases (IgA1P) from diverse pathogenic bacteria specifically cleave human immunoglobulin A1 (IgA1) at the hinge region, thereby thwarting protective… Continue reading Streptococcus pneumoniae IgA1 protease: A metalloprotease that can catalyze in a split manner in vitro
2016 / Peptide Science
The conformational characteristics of protected homooligomeric Boc-[β3(R)Val]n-OMe, n = 1, 2, 3, 4, 6, 9 and 12 have been investigated… Continue reading Conformational properties and aggregation of homooligomeric β3(R)-valine peptides in organic solvents
2016 / Structural Chemistry
In this paper we report on the synthesis and solution conformation of a new set of structurally related polycationic branched… Continue reading Synthesis, conformation and cytotoxicity of new, branched polymeric polypeptides containing hydrophobic amino acid or arginine moiety
2017 / Colloids and Surfaces B: Biointerfaces
Regardless of the route of administration, some or all of a therapeutic agent will appear in the blood stream, where… Continue reading Influence of core and maltose surface modification of PEIs on their interaction with plasma proteins—Human serum albumin and lysozyme
2016 / Journal of Industrial and Engineering Chemistry
In this study, a novel oral insulin delivery system was prepared by combining two different artificial polypeptides with insulin. Negatively… Continue reading Polypeptide-based polyelectrolyte complexes overcoming the biological barriers of oral insulin delivery
2016 / Journal of Photochemistry and Photobiology B: Biology
Garcinia nervosa is an abundant source of bioactive phytochemicals. The present paper deals with the isolation of a novel isoflavone 5,7-dihydroxy-3-(3′-hydroxy-4′,5′-dimethoxyphenyl)-6-methoxy-4H-chromen-4-one… Continue reading Structure elucidation, DNA binding specificity and antiproliferative proficiency of isolated compounds from Garcinia nervosa
