KnowledgeBase Articles Archive

Enhanced Articular Cartilage by Human Mesenchymal Stem Cells in Enzymatically Mediated Transiently RGDS–Functionalized Collagen–Mimetic Hydrogels

2017 / Acta Biomaterialia

Recapitulation of the articular cartilage microenvironment for regenerative medicine applications faces significant challenges due to the complex and dynamic biochemical… Continue reading Enhanced Articular Cartilage by Human Mesenchymal Stem Cells in Enzymatically Mediated Transiently RGDS–Functionalized Collagen–Mimetic Hydrogels

Hydrocarbon-stapled lipopeptides exhibit selective antimicrobial activity

2017 / Peptide Science

Antimicrobial peptides (AMPs) occur widely in nature and have been studied for their therapeutic potential. AMPs are of interest due… Continue reading Hydrocarbon-stapled lipopeptides exhibit selective antimicrobial activity

Conformational dynamics and self-association of intrinsically disordered Huntingtin exon 1 in cells

2017 / Physical Chemistry Chemical Physics

Huntington’s disease is caused by a CAG trinucleotide expansion mutation in the Huntingtin gene that leads to an artificially long… Continue reading Conformational dynamics and self-association of intrinsically disordered Huntingtin exon 1 in cells

Two-Step Amyloid Aggregation: Sequential Lag Phase Intermediates

2017 / Scientific Reports

The self-assembly of proteins into fibrillar structures called amyloid fibrils underlies the onset and symptoms of neurodegenerative diseases, such as… Continue reading Two-Step Amyloid Aggregation: Sequential Lag Phase Intermediates

Detection of Naja atra Cardiotoxin Using Adenosine-Based Molecular Beacon

2017 / Toxins

This study presents an adenosine (A)-based molecular beacon (MB) for selective detection of Naja atra cardiotoxin (CTX) that functions by utilizing the… Continue reading Detection of Naja atra Cardiotoxin Using Adenosine-Based Molecular Beacon

Anti-glycation and anti-oxidative effects of a phenolic-enriched maple syrup extract and its protective effects on normal human colon cells

2017 / Food & Function

Oxidative stress and free radical generation accelerate the formation of advanced glycation endproducts (AGEs) which are linked to several chronic… Continue reading Anti-glycation and anti-oxidative effects of a phenolic-enriched maple syrup extract and its protective effects on normal human colon cells

Synergistic antitumor activity of a self-assembling camptothecin and capecitabine hybrid prodrug for improved efficacy

2017 / Journal of Controlled Release

The direct use of anticancer drugs to create their own nanostructures is an emerging concept in the field of drug… Continue reading Synergistic antitumor activity of a self-assembling camptothecin and capecitabine hybrid prodrug for improved efficacy

Peptide Conjugates of Benzene Carboxylic Acids as Agonists and Antagonists of Amylin Aggregation

2017 / Bioconjugate Chemistry

Human islet amyloid polypeptide (hIAPP), also known as amylin, is a 37 residue peptide hormone that is stored and co-secreted… Continue reading Peptide Conjugates of Benzene Carboxylic Acids as Agonists and Antagonists of Amylin Aggregation

Direct Measurement of the Effect of Cholesterol and 6-Ketocholestanol on Membrane Dipole Field Using Vibrational Stark Effect Spectroscopy Coupled with Molecular Dynamics Simulations

2017 / The Journal of Physical Chemistry B

Biological membranes are heterogeneous structures with complex electrostatic profiles arising from lipids, sterols, membrane proteins, and water molecules. We investigated… Continue reading Direct Measurement of the Effect of Cholesterol and 6-Ketocholestanol on Membrane Dipole Field Using Vibrational Stark Effect Spectroscopy Coupled with Molecular Dynamics Simulations

Residues in the RecQ C-terminal Domain of the Human Werner Syndrome Helicase are Involved in Unwinding G-quadruplex DNA

2017 / The Journal of Biological Chemistry

The structural and biophysical properties typically associated with G-quadruplex (G4) structures renders them a significant block for DNA replication, which… Continue reading Residues in the RecQ C-terminal Domain of the Human Werner Syndrome Helicase are Involved in Unwinding G-quadruplex DNA

Synthesis, Characterization and Immunological Evaluation of Self-Adjuvanting Group A Streptococcal Vaccine Candidates Bearing Various Lipidic Adjuvanting Moieties

2017 / ChemBioChem

Four group A streptococcal glyco-lipopeptide vaccine candidates were prepared and characterized, each possessing different lipidic adjuvanting moieties. The immunogenicity of… Continue reading Synthesis, Characterization and Immunological Evaluation of Self-Adjuvanting Group A Streptococcal Vaccine Candidates Bearing Various Lipidic Adjuvanting Moieties

Carbohydrate Tethered Cyanostilbene Fluorogen: Unique Emission and Preferential Protein Binding

2017 / Chemistry Select

A simple and efficient construction of a water-soluble glycoconjugate bearing a cyanostilbene with glucose pendant and its interaction with proteins… Continue reading Carbohydrate Tethered Cyanostilbene Fluorogen: Unique Emission and Preferential Protein Binding

Effect of β-Cyclodextrin on the Multistate Species Distribution of 3-Methoxy-4′,7-dihydroxyflavylium. Discrimination of the Two Hemiketal Enantiomers

2017 / Journal of Agricultural and Food Chemistry

The effect of β-cyclodextrin on the mole fraction distribution of the multistate species of the anthocyanin model compound, 3-methoxy-4′,7-dihydroxyflavylium, was… Continue reading Effect of β-Cyclodextrin on the Multistate Species Distribution of 3-Methoxy-4′,7-dihydroxyflavylium. Discrimination of the Two Hemiketal Enantiomers

Alpha-synuclein alters differently gene expression of Sirts, PARPs and other stress response proteins: implications for neurodegenerative disorders

2017 / Molecular Neurobiology

Alpha-synuclein (ASN) is a presynaptic protein that can easily change its conformation under different types of stress. It’s assumed that… Continue reading Alpha-synuclein alters differently gene expression of Sirts, PARPs and other stress response proteins: implications for neurodegenerative disorders

The random co-polymer glatiramer acetate rapidly kills primary human leukocytes through sialic-acid-dependent cell membrane damage

2017 / Biochimica et Biophysica Acta (BBA) - Biomembranes

The formulation glatiramer acetate (GA) is widely used in therapy of multiple sclerosis. GA consists of random copolymers of four… Continue reading The random co-polymer glatiramer acetate rapidly kills primary human leukocytes through sialic-acid-dependent cell membrane damage

CD25 targeted therapy of chemotherapy resistant leukemic stem cells using DR5 specific TRAIL peptide

2017 / Stem Cell Research

Chemotherapy resistant leukemic stem cells (LSCs) are being targeted as a modern therapeutic approach to prevent disease relapse. LSCs isolated… Continue reading CD25 targeted therapy of chemotherapy resistant leukemic stem cells using DR5 specific TRAIL peptide

Guazuma ulmifolia bark-synthesized Ag, Au and Ag/Au alloy nanoparticles: Photocatalytic potential, DNA/protein interactions, anticancer activity and toxicity against 14 species of microbial pathogens

2017 / Journal of Photochemistry and Photobiology B: Biology

In the present study, we focused on a quick and green method to fabricate Ag, Au and Ag/Au alloy nanoparticles… Continue reading Guazuma ulmifolia bark-synthesized Ag, Au and Ag/Au alloy nanoparticles: Photocatalytic potential, DNA/protein interactions, anticancer activity and toxicity against 14 species of microbial pathogens

Peptides derived from α-Lactalbumin membrane binding helices oligomerize in presence of lipids and disrupt bilayers

2017 / Biochimica et Biophysica Acta (BBA) - Biomembranes

Helix A and -C of α-Lactalbumin, a loosely folded amphitropic protein, perturb lipid monolayers by the formation of amyloid pore-like… Continue reading Peptides derived from α-Lactalbumin membrane binding helices oligomerize in presence of lipids and disrupt bilayers

Influence of glutamic acid residues and pH on the properties of transmembrane helices

2017 / Biochimica et Biophysica Acta (BBA) - Biomembranes

Negatively charged side chains are important for the function of particular ion channels and certain other membrane proteins. To investigate… Continue reading Influence of glutamic acid residues and pH on the properties of transmembrane helices

Biomimetic Construction of Protein-Conjugated Gold Clusters for Detecting Hg2+

2017 / Colloids and Surfaces A: Physicochemical and Engineering Aspects

Mercury ion (Hg2+) pollution has deleterious effects on the environment and human health. Herein, through one-step biomimetic mineralization of metal… Continue reading Biomimetic Construction of Protein-Conjugated Gold Clusters for Detecting Hg2+

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KnowledgeBase Articles

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Enhanced Articular Cartilage by Human Mesenchymal Stem Cells in Enzymatically Mediated Transiently RGDS–Functionalized Collagen–Mimetic Hydrogels

Hydrocarbon-stapled lipopeptides exhibit selective antimicrobial activity

Conformational dynamics and self-association of intrinsically disordered Huntingtin exon 1 in cells

Two-Step Amyloid Aggregation: Sequential Lag Phase Intermediates

Detection of Naja atra Cardiotoxin Using Adenosine-Based Molecular Beacon

Anti-glycation and anti-oxidative effects of a phenolic-enriched maple syrup extract and its protective effects on normal human colon cells

Synergistic antitumor activity of a self-assembling camptothecin and capecitabine hybrid prodrug for improved efficacy

Peptide Conjugates of Benzene Carboxylic Acids as Agonists and Antagonists of Amylin Aggregation

Direct Measurement of the Effect of Cholesterol and 6-Ketocholestanol on Membrane Dipole Field Using Vibrational Stark Effect Spectroscopy Coupled with Molecular Dynamics Simulations

Residues in the RecQ C-terminal Domain of the Human Werner Syndrome Helicase are Involved in Unwinding G-quadruplex DNA

Synthesis, Characterization and Immunological Evaluation of Self-Adjuvanting Group A Streptococcal Vaccine Candidates Bearing Various Lipidic Adjuvanting Moieties

Carbohydrate Tethered Cyanostilbene Fluorogen: Unique Emission and Preferential Protein Binding

Effect of β-Cyclodextrin on the Multistate Species Distribution of 3-Methoxy-4′,7-dihydroxyflavylium. Discrimination of the Two Hemiketal Enantiomers

Alpha-synuclein alters differently gene expression of Sirts, PARPs and other stress response proteins: implications for neurodegenerative disorders

The random co-polymer glatiramer acetate rapidly kills primary human leukocytes through sialic-acid-dependent cell membrane damage

CD25 targeted therapy of chemotherapy resistant leukemic stem cells using DR5 specific TRAIL peptide

Guazuma ulmifolia bark-synthesized Ag, Au and Ag/Au alloy nanoparticles: Photocatalytic potential, DNA/protein interactions, anticancer activity and toxicity against 14 species of microbial pathogens

Peptides derived from α-Lactalbumin membrane binding helices oligomerize in presence of lipids and disrupt bilayers

Influence of glutamic acid residues and pH on the properties of transmembrane helices

Biomimetic Construction of Protein-Conjugated Gold Clusters for Detecting Hg2+

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