Found 9617 Results / Page 364 of 481
2016 / Journal of Molecular Biology
Candidates for the toxic molecular species in the expanded polyglutamine (polyQ) repeat diseases range from various types of aggregates to… Continue reading Backbone engineering within a latent β-hairpin structure to design inhibitors of polyglutamine amyloid formation
2016 / Materials Science and Engineering: C
d-Form and l-form peptide nanofiber scaffolds can spontaneously form stable β-sheet secondary structures and nanofiber hydrogel scaffolds, and hold some promise… Continue reading Designer bFGF-incorporated d-form self-assembly peptide nanofiber scaffolds to promote bone repair
2016 / Journal of Molecular Biology
RavA is a MoxR AAA + protein that functions together with a partner protein that we termed ViaA containing a von… Continue reading The RavA-ViaA Chaperone-Like System Interacts with and Modulates the Activity of the Fumarate Reductase Respiratory Complex
2016 / Journal of Molecular Liquids
A room temperature ionic liquid (RT-IL) made by the negatively charged water soluble meso-tetrakis(4 sulfonatophenyl)porphyrin (TPPS4) and the positively charged… Continue reading Synthesis, Characterization and Aggregation Behaviour of Room Temperature Ionic Liquid Based on Porphyrin- trihexyl(tetradecyl)Phosphonium Adduct
2016 / Biomaterials Science
Mesenchymal stem cells (MSCs) can ameliorate renal injury and accelerate repair of acute kidney injury. Herein, we developed a collagen/poly(γ-glutamic… Continue reading An injectable collagen/poly(γ-glutamic acid) hydrogel as a scaffold of stem cells and α-lipoic acid for enhanced protection against renal dysfunction
2016 / International Journal of Biological Macromolecules
Surfactant-protein mixtures have attracted considerable research interest in recent years at the interface of chemical biology and medicinal chemistry. Herein,… Continue reading Unraveling the interaction of hemoglobin with a biocompatible and cleavable oxy-diester-functionalized gemini surfactant
2017 / Phytochemistry Letters
A new 2-carboxy-dihydrostilbene glucoside, 2-carboxy-3,5,4′-trihydroxydihydrostilbene 3-O-β-d-glucopyranoside (1) and a new flavan diglycoside, (2S)-5,7,4′-trihydroxyflavan 7-O-β-d-apiofuranosyl-(1 → 6)-O-β-d-glucopyranoside (3) were isolated from the aerial… Continue reading 2-Carboxy-dihydrostilbene and flavan glycosides from Desmodium heterocarpon
2016 / Scientific Reports
Bispecific antibodies (BsAbs), with the ability to recognize two different epitopes simultaneously, offer remarkable advantages in bioassays, cancer therapy, biosensors,… Continue reading A detergent-based procedure for the preparation of IgG-like bispecific antibodies in high yield
2016 / Molecular Microbiology
Trimethylamine (TMA) and trimethylamine N-oxide (TMAO) are widespread in the ocean and are important nitrogen source for bacteria. TMA monooxygenase (Tmm),… Continue reading Structural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamine N-oxide
2016 / Polymer Chemistry
Synthetic chiral polymers and helical polymers are finding increasing applications in catalysis and chiral recognition. Herein we have induced the… Continue reading Chiral Anion Triggered Helical Poly(ionic liquids)
2016 / PLoS ONE
Salmonella enterica species are enteric pathogens that cause severe diseases ranging from self-limiting gastroenteritis to enteric fever and sepsis in humans.… Continue reading Role of T3SS-1 SipD Protein in Protecting Mice against Non-typhoidal Salmonella Typhimurium
2016 / JACS
Thermosensing is critical for the expression of virulence genes in pathogenic bacteria that infect warm-blooded hosts. Proteins of the Hha-family,… Continue reading Graded Structural Polymorphism in a Bacterial Thermosensor Protein
2016 / Biophysical Journal
The signaling of a G protein-coupled receptor (GPCR) is dictated by the complementary responsiveness of interacting intracellular effectors such as… Continue reading Construction of Structural Mimetics of the Thyrotropin Receptor Intracellular Domain
2017 / New Journal of Chemistry
Two new dinuclear iridium (Ir) complexes bridged by a conjugated aromatic tppz ligand, (bhq)2Ir(tppz)Ir(bhq)2 (1) and (ppy)2Ir(tppz)Ir(ppy)2 (2) (bhq = benzo(h)quinolone, ppy… Continue reading Diiridium(III) complexes: luminescent probes and sensors for G-quadruplex DNA and endoplasmic reticulum imaging
2017 / Chemical Science
Amyloid-β peptides (Aβ) fibrillation is the hallmark of Alzheimer’s disease (AD). However, it has been challenging to discover potent agents… Continue reading A resorcinarene for inhibition of Aβ fibrillation
2016 / Metallomics
Ferredoxins are protein mediators of biological electron-transfer reactions and typically contain either [2Fe–2S] or [4Fe–4S] clusters. Two ferredoxin homologues have… Continue reading Mapping cellular Fe–S cluster uptake and exchange reactions – divergent pathways for iron–sulfur cluster delivery to human ferredoxins
2016 / Scientific Reports
KRAS is mutated in >90% of pancreatic ductal adenocarcinomas. As its inactivation leads to tumour regression, mutant KRAS is considered an attractive target… Continue reading Lipid-modified G4-decoy oligonucleotide anchored to nanoparticles: delivery and bioactivity in pancreatic cancer cells
2016 / RSC Advances
Four new quaternary phenanthroindolizidine alkaloids (1–4) were isolated from the whole plants of Tylophora atrofolliculata. Their structures were elucidated on the… Continue reading G-Quadruplex DNA-binding quaternary alkaloids from Tylophora atrofolliculata
2016 / RSC Advances
Five new cadinane sesquiterpenoids, pholiotins A–E (1–5), and three known compounds, 11-hydroxy-1(10)-valencen-2-one (6), 8,11-dihydroxy-1(10)-eremophilen-2-one (7) and durgamone (8), were isolated… Continue reading New cadinane sesquiterpenoids from the basidiomycetous fungus Pholiota sp.
2017 / Journal of Materials Chemistry B
Protein immobilization is of significant interest for applications in biosensing, drug delivery and bioconversion, and challenges still remain for the in… Continue reading Enhanced green fluorescence protein/layered double hydroxide composite ultrathin films: bio-hybrid assembly and potential application as a fluorescent biosensor
