Found 9617 Results / Page 365 of 481
2016 / Physical Chemistry Chemical Physics
Supramolecular rearrangements are crucial in determining the response of stimuli sensitive soft matter systems such as those formed by mixtures… Continue reading Supramolecular assembly of thermoresponsive steroidal surfactant with oppositely charged thermoresponsive block copolymer
2016 / Chemistry A European Journal
Synthetic (glyco-)peptides inspired by proteins able to self-assemble are appealing biomaterials in the field of tissue engineering and regenerative medicine.… Continue reading Photoinduced Thiol-ene chemistry applied to the synthesis of elastin-inspired self-assembling glycopeptides
2016 / PLoS ONE
Phycocyanobilin (PCB) binds with high affinity (2.2 x 106 M-1 at 25°C) to human serum albumin (HSA) at sites located in IB… Continue reading Stabilization of Human Serum Albumin by the Binding of Phycocyanobilin, a Bioactive Chromophore of Blue-Green Alga Spirulina: Molecular Dynamics and Experimental Study
2016 / Journal of Materials Chemistry B
Non-viral vectors for gene therapy such as DNA-cationic probe complexes offer important bio-safety advantages over viral approaches, due to their… Continue reading Effective control of the intrinsic DNA morphology by photosensitive polyamines
2016 / Scientific Reports
The research on secondary metabolites of Aspergillus lentulus afforded eight unusual heterodimeric tetrahydroxanthone derivatives, lentulins A−H (2−9), along with the known compound… Continue reading Unusual dimeric tetrahydroxanthone derivatives from Aspergillus lentulus and the determination of their axial chiralities
2016 / Proteins: Structure, Function, and Bioinformatics
It is important to identify hotspot residues that determine protein-protein interactions in interfaces of macromolecular complexes. We have applied a… Continue reading Combining ancestral sequence reconstruction with protein design to identify an interface hotspot in a key metabolic enzyme complex
2017 / International Journal of Biological Macromolecules
Globally, renal cell carcinomas (RCCs) represent a major portion of patients suffering from cancer. Temsirolimus is an anti-renal cancer drug… Continue reading Temsirolimus induced structural transition of cancerous renal cystatin to normal form in rats: In vitro mechanistic approach underlying renal cancer prevention
2016 / International Journal of Biological Macromolecules
Among Enterobacteriaceae, CTX-M type extended spectrum beta lactamase confers potent hydrolytic activity against cephalosporin group of antibiotics. Strains producing CTX-M type beta… Continue reading Structural insight into mode of binding of Meropenem to CTX-M-15 type β-lactamase
2017 / Journal of Inorganic Biochemistry
This study introduces a pair of newly synthesized silver complexes, [Ag2(HGly)2]n(NO3)2n (1) and [Ag(Nam)2]NO3·H2O (2) (Gly – glycine, Nam – nicotinamide),… Continue reading New silver complexes with bioactive glycine and nicotinamide molecules – Characterization, DNA binding, antimicrobial and anticancer evaluation
2016 / Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Parkinson’s disease (PD) presents with neuropathological inclusions called Lewy bodies, which are primarily composed of fibrillar α-synuclein. Recently, we characterized… Continue reading Analysis of sheep α-synuclein provides a molecular strategy for the reduction of fibrillation
2016 / Colloids and Surfaces A: Physicochemical and Engineering Aspects
Keeping in mind the contemporary environmental concern raised over the disposal of surfactants into water bodies, we synthesized biodegradable cationic… Continue reading An ester-functionalized cationic gemini surfactant mediated structural transitions of porcine serum albumin (PSA) via binding interaction
2016 / Archives of Biochemistry and Biophysics
One of the proposed mechanisms of homocysteine (Hcy) toxicity is the post-translational modification of proteins by its metabolite, homocysteine thiolactone… Continue reading Conformational status of cytochrome c upon N-homocysteinylation: Implications to cytochrome c release
2016 / Biophysical Journal
We have used chemical synthesis, electron paramagnetic resonance (EPR), and circular dichroism to detect and analyze the structural dynamics of… Continue reading Calcium-Dependent Structural Dynamics of a Spin-Labeled RyR Peptide Bound to Calmodulin
2016 / Scientific Reports
Neuraminidase 1 (NEU1) is a lysosomal sialidase catalyzing the removal of terminal sialic acids from sialyloconjugates. A plasma membrane-bound NEU1… Continue reading New Insights into Molecular Organization of Human Neuraminidase-1: Transmembrane Topology and Dimerization Ability
2016 / Journal of Bacteriology
Sequence comparisons showed that the sulfur oxygenase reductase (SOR) of the haloalkaliphilic bacterium Thioalkalivibrio paradoxus Arh 1 (TpSOR) is branching deeply within… Continue reading A Sulfur Oxygenase from the Haloalkaliphilic Bacterium Thioalkalivibrio paradoxus with atypically low Reductase Activity
2016 / Biophysical Journal
The aggregation of membrane-bound α-synuclein (αS) into oligomers and/or amyloid fibrils has been suggested to cause membrane damage in in vitro model… Continue reading Membrane-Bound Alpha Synuclein Clusters Induce Impaired Lipid Diffusion and Increased Lipid Packing
2017 / Carbon
The construction of DNA-carbon dot (CD) hybrid hydrogel for targeted and sustained release of drug molecules is reported here. Amine… Continue reading Carbon dots assisted formation of DNA hydrogel for sustained release of drug
2016 / Sensors and Actuators B: Chemical
A dual functional AIE active amphiphilic molecule, sodium N,N’-bis[4-(3-sulfonatopropoxyl)] salicylidene (BSPS), was designed and synthesized. Due to its amphiphilic nature, BSPS could spontaneously… Continue reading A Dual Functional Fluorescent Sensor for Human Serum Albumin and Chitosan
2016 / Sensors and Actuators B: Chemical
Amyloid β-peptide (Aβ) is now considered as a key predictor for preclinical diagnosis of Alzheimer’s disease (AD), whose diagnosis is… Continue reading Colorimetric sandwich immunosensor for Aβ(1-42) based on dual antibody-modified gold nanoparticles
2016 / International Journal of Biological Macromolecules
Protease inhibitors are essential bio-molecules that serve as a model system for the study of protein structure and protease-protease inhibitor… Continue reading Structure-function relationship of a bio-pesticidal trypsin/chymotrypsin inhibitor from winged bean
