Found 9617 Results / Page 367 of 481
2016 / Process Biochemistry
In this study, a novel and economic method for refolding and purifying recombinant tissue plasminogen activator derivative (r-PA; reteplase) was… Continue reading Purification and efficient refolding process for recombinant tissue-type plasminogen activator derivative (reteplase) using glycerol and Tranexamic acid
2016 / Nucleic Acids Research
The potential use of G-quadruplex (GQ) stabilizing small molecules as anti-cancer drugs has created a flurry of activity on various… Continue reading A single molecule study of a fluorescently labeled telomestatin derivative and G-quadruplex interactions
2016 / Chemistry A European Journal
1,N6-Ethenoadenine (eA) and cytosine (C) are able to form two different metal-mediated base pairs. When the glycosidic bonds are arranged… Continue reading Relative strand orientation in a DNA duplex controls the nuclearity of a metal-mediated base pair
2016 / Nucleic Acids Research
The single-step assembly of supramolecular complexes containing both i-motifs and G-quadruplexes (G4s) is demonstrated. This can be achieved because the… Continue reading Assembly of supramolecular DNA complexes containing both G-quadruplexes and i-motifs by enhancing the G-repeat-bearing capacity of i-motifs
2016 / Scientific Reports
Considering that the prevalence of antibiotic-resistant pathogenic bacteria is largely increasing, a thorough understanding of penicillin-binding proteins (PBPs) is of… Continue reading Biochemical and Structural Analysis of a Novel Esterase from Caulobacter crescentus related to Penicillin-Binding Protein (PBP)
2016 / Chemistry A European Journal
The formation of distinct supramolecular assemblies, including a metastable species, is revealed for a lipophilic guanosine (G) derivative in solution… Continue reading Co-existence of distinct supramolecular assemblies in solution and in the solid state
2016 / Chemistry A European Journal
An extended challenge is to control the supramolecular interaction and get information beyond molecules. An intriguing selfassembly of a perylene-3,4,9,10-tetracarboxylic… Continue reading Adaptive self-assembly behaviour restrained by supramolecular crystallization and molecular recognition
2016 / Extremophiles
A hyperthermophilic and thermostable xylanase of 82 kDa (TtXynA) was purified from the culture supernatant of T. terrestris Co3Bag1, grown on carboxymethyl cellulose… Continue reading The thermophilic biomass-degrading fungus Thielavia terrestris Co3Bag1 produces a hyperthermophilic and thermostable β-1,4-xylanase with exo- and endo-activity
2016 / Scientific Reports
The importance of Glucagon like peptide 1 (GLP-1) for metabolic control and insulin release sparked the evolution of genes mimicking… Continue reading Monotreme glucagon-like peptide-1 in venom and gut: one gene – two very different functions
2017 / Fitoterapia
Four new megastigmane glycosides, eucomegastigsides A-D (2, 3, 5 and 7), together with three known megastigmane glycosides, (6R, 7E, 9R)-9-hydroxy-4, 7-megastigmadien-3-one-9-O-[α-l-arabinopyranosyl-(l → 6)-β-d-glucopyranoside (1), foliasalacioside B1 (4) and… Continue reading Megastigmane glycosides from leaves of Eucommia ulmoidesOliver with ACE inhibitory activity
2016 / Scientific Reports
Aggregation of alpha synuclein (α-syn) leading to dopaminergic neuronal death has been recognized as one of the main pathogenic factors… Continue reading Inhibition of alpha-synuclein aggregation by multifunctional dopamine agonists assessed by a novel in vitro assay and an in vivo Drosophila synucleinopathy model
2016 / Nucleic Acids Research
Higher-order plants and mammals use similar mechanisms to repair and tolerate oxidative DNA damage. Most studies on the DNA repair… Continue reading Histone chaperone activity of Arabidopsis thaliana NRP1 is blocked by cytochrome c
2016 / International Journal of Biological Macromolecules
A polypeptide coded as PGC was isolated from Arca subcrenata muscle using ion exchange, Sephadex G-50 gel chromatography and RP-HPLC. PGC was… Continue reading Purification and characterization of an antibacterial and anti-inflammatory polypeptide from Arca subcrenata
2016 / Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Membrane fusion is a highly regulated process that allows enveloped viruses to enter cells and replicate. Viral glycoproteins trigger membrane… Continue reading A biophysical characterization of the interaction of a hepatitis C virus membranotropic peptide with micelles
2014 / European Journal of Medicinal Chemistry
The development of peptide fusion inhibitors based on short synthetic peptides represents a promising option in the fight against HIV-1… Continue reading A cyclic GB virus C derived peptide with anti-HIV-1 activity targets the fusion peptide of HIV-1
2015 / Journal of Structural Biology
Spt5 (NusG in bacteria) is the only RNA polymerase-associated factor known to be conserved in all three domains of life.… Continue reading Structural and biochemical insights into the DNA-binding mode of MjSpt4p:Spt5 complex at the exit tunnel of RNAPII
2013 / Biochemical and Biophysical Research Communications
Here we enhanced the stability and biophysical properties of mRFP1 through a combination of canonical and non-canonical amino acid mutagenesis.… Continue reading Enhancing the biophysical properties of mRFP1 through incorporation of fluoroproline
2015 / Biochimica et Biophysica Acta (BBA) - Biomembranes
The reovirus p10 fusion-associated small transmembrane (FAST) proteins are the smallest known membrane fusion proteins, and evolved specifically to mediate… Continue reading The p10 FAST protein fusion peptide functions as a cystine noose to induce cholesterol-dependent liposome fusion without liposome tubulation
2013 / Journal of Molecular Biology
The entry of enveloped viruses into cells requires protein-catalyzed fusion of the viral and cell membranes. The structure–function relation of… Continue reading Membrane-Dependent Conformation, Dynamics, and Lipid Interactions of the Fusion Peptide of the Paramyxovirus PIV5 from Solid-State NMR
2012 / International Journal of Pharmaceutics
Four peptide sequences corresponding to the E1 protein of GBV-C: NCCAPEDIGFCLEGGCLV (P7), APEDIGFCLEGGCLVALG (P8), FCLEGGCLVALGCTICTD (P10) and QAGLAVRPGKSAAQLVGE (P18) were… Continue reading Physicochemical characterization of GBV-C E1 peptides as potential inhibitors of HIV-1 fusion peptide: Interaction with model membranes
