The production of anti-drug antibodies can impact significantly upon the safety and efficacy of biotherapeutics. It is known that various… Continue reading Influence of E. coli chaperone DnaK on protein immunogenicity
Leah Pandiscia, PhD
July 28, 2017
IM30/Vipp1 proteins are crucial for thylakoid membrane biogenesis in chloroplasts and cyanobacteria. A characteristic C-terminal extension distinguishes these proteins from… Continue reading The IM30/Vipp1 C-terminus associates with the lipid bilayer and modulates membrane fusion
Leah Pandiscia, PhD
July 28, 2017
We report here a new electrochemical probe for the development of a sensitive, and selective sandwich-type electrochemical immunosensor for the… Continue reading BSA-templated Pb Nanocluster as a Biocompatible Signaling Probe for Electrochemical EGFR Immunosensing
Leah Pandiscia, PhD
July 28, 2017
Cytochrome c undergoes structural variations upon binding of cardiolipin, one of the phospholipids constituting the mitochondrial membrane. Although several mechanisms governing cytochrome c/cardiolipin… Continue reading The key role played by charge in the interaction of cytochrome c with cardiolipin
Leah Pandiscia, PhD
July 28, 2017
In this short communication we report optimized procedures for the chiral separation of non-charged [6]helicene (1) and cationic derivative 1-butyl-3-(2-methyl[6]helicenyl)-imidazolium… Continue reading Development of Separation Methods for the Chiral Resolution of Hexahelicenes
Leah Pandiscia, PhD
July 28, 2017
Peptide–lipid interactions support a variety of biological functions. Of particular interest are those that underpin fundamental mechanisms of innate immunity… Continue reading Modulating charge-dependent and folding-mediated antimicrobial interactions at peptide–lipid interfaces
Leah Pandiscia, PhD
July 28, 2017
As reported in our previous work, banded spherulites of isotactic poly(2-vinylpyridine) (iP2VP) with preferred handedness of twisted lamellae can be… Continue reading Directed crystallization of isotactic poly(2-vinylpyridine) for preferred lamellar twisting by chiral dopants
Leah Pandiscia, PhD
July 28, 2017
Pathogenicity of Mycobacterium tuberculosis (M. tb) is mediated by the ESX-1 secretion system, which exports EsxA and EsxB, the major virulence factors… Continue reading EspC forms a filamentous structure in the cell envelope of Mycobacterium tuberculosis and impacts ESX-1 secretion
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Two new C-15 enolic acyl phragmalin-type limonoid orthoesters (1-2) which possessed a C-15-propionyl phragmalin skeleton and two new mexicanolide-type limonoids… Continue reading Four new limonoids from the seeds of Chukrasia tabularis A. Juss.
Leah Pandiscia, PhD
July 28, 2017
Nisin is a well-recognised antimicrobial peptide (AMP) used in food industry. However, efficacy of the peptide has been compromised due… Continue reading Interfacial assembly at silver nanoparticle enhances the antibacterial efficacy of nisin
Leah Pandiscia, PhD
July 28, 2017
hRSV is the major causative agent of acute respiratory infections. Among its eleven proteins, M2-1 is a transcription antiterminator, making… Continue reading Biophysical characterization of the interaction between M2-1 protein of hRSV and quercetin
Leah Pandiscia, PhD
July 28, 2017
Nucleic acids adopt a broad array of hydrogen-bonded structures that enable their diverse roles in the cell; even the familiar… Continue reading Probing A –form DNA: A fluorescent aminosugar probe and dual recognition by anthraquinone-neomycin conjugates
Leah Pandiscia, PhD
July 28, 2017
Four new glycosides including a eudesmane-type sesquiterpenoid (1), a guaiane-type sesquiterpenoid (2), and two C14-polyacetylenes (3, 4) were isolated from the… Continue reading Sesquiterpenoid and C14-polyacetylene glycosides from the rhizomes of Atractylodes lancea
Leah Pandiscia, PhD
July 28, 2017
In the current work, we describe the identification and characterization of the first plasmid-encoded P450 (CYP107DY1) from a Bacillus species. The recombinant… Continue reading Identification of a new plasmid-encoded cytochrome P450 CYP107DY1 from Bacillus megaterium with a catalytic activity towards mevastatin
Leah Pandiscia, PhD
July 28, 2017
A series of novel substituted acetylene monomers bearing fluorene pendant groups (C13H9COCH2CH2CO-R-CH2C ≡ CH, R = NH (IV1), R = O (IV2), R = NHCH(CH3)CONH (IV3), R = NHCH(CH3)COO (IV4))… Continue reading Synthesis and chiroptical properties of novel helical polyacetylenes containing fluorene pendant groups in the side chains
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
(±) Sampsonins A–B (1–2), two pairs of racemic polyprenylated benzophenones, were isolated from the aerial parts of Hypericum sampsonii and successfully separated… Continue reading Chiral separation and absolute configurations of two pairs of racemic polyprenylated benzophenones from Hypericum sampsonii
Leah Pandiscia, PhD
July 28, 2017
Phi11, a temperate bacteriophage of Staphylococcus aureus, has been found to harbor a cro repressor gene which facilitates Phi11 to… Continue reading Changes in the Functional Activity of Phi11 Cro Protein is Mediated by Various Ions
Leah Pandiscia, PhD
July 28, 2017
Drawing inspiration from the field of designer self-assembling materials, this work is aimed to focus on the self-assembling nature of… Continue reading Self-assembly of keratin peptides: Its implication on the performance of electrospun PVA nanofibers
Leah Pandiscia, PhD
July 28, 2017