Found 9617 Results / Page 378 of 481
2016 / Biochimica et Biophysica Acta (BBA) - General Subjects
To overcome the hurdles of cisplatin, majorly its toxicity and resistance, there has been extensive search for alternative anti-cancer metal-based… Continue reading Synthesis, biological characterization and evaluation of molecular mechanisms of novel copper complexes as anticancer agents
2017 / International Journal of Biological Macromolecules
Ice nucleation protein (INP) with its functional domain consisting of multiple 48-residue repeat units effectively induces super-cooled water into ice.… Continue reading Biophysical characterization of soluble Pseudomonas syringae ice nucleation protein InaZ fragments
2016 / Phytochemistry
Nine dimeric xanthanolides, pungiolides F–N, and five known analogues, pungiolides A–E, were isolated from fruits of Xanthium chinense. Their structures were… Continue reading Cytotoxic dimeric xanthanolides from fruits of Xanthium chinense
2016 / Structure
The spliceosomal B complex-specific protein Prp38 forms a complex with the intrinsically unstructured proteins MFAP1 and Snu23. Our binding and… Continue reading Scaffolding in the Spliceosome via Single α Helices
2016 / Dental Materials
Dentin collagen can be modified by some plant-derived flavonoids to improve properties of dentin organic matrix. Hesperidin (HPN), a hesperetin-7-O-rutinoside… Continue reading Hesperidin interaction to collagen detected by physico-chemical techniques
2016 / International Journal of Biological Macromolecules
Nanotechnology is one of the fastest growing fields of science owing to use of nanomaterials in industries and medicine across… Continue reading Structural transition of kidney cystatin induced by silicon dioxide nanoparticles: An implication for renal diseases
2016 / Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
The degradation of histamine catalyzed by the SAM-dependent histamine N-methyltransferase (HNMT) is critically important for the maintenance of neurological processes. Recently,… Continue reading Leucine 208 in human histamine N-methyltransferase emerges as a hotspot for protein stability rationalizing the role of the L208P variant in intellectual disability
2016 / Biophysical Journal
There is a significant need for developing compounds that kill Cryptococcus neoformans, the fungal pathogen that causes meningoencephalitis in immunocompromised individuals.… Continue reading Mode of Action of a Designed Antimicrobial Peptide: High Potency against Cryptococcus neoformans
2016 / Fitoterapia
Eight new flavonoid dimers, named cochinchinenins I–M (1–5), including three pairs of enantiomers (1a/1b–3a/3b) and two optically pure flavonoid dimers… Continue reading Flavonoid dimers from the total phenolic extract of Chinese dragon’s blood, the red resin of Dracaena cochinchinensis
2016 / European Journal of Inorganic Chemistry
Cisplatin is a widely used anticancer drug for the treatment of a variety of human malignancies. It has been reported… Continue reading Cisplatin Preferentially Binds to Zinc Finger Proteins Containing C3H1 or C4 Motif
2016 / The European Physical Journal Special Topics
Polyelectrolyte complexes (PECs) have a broad range of promising applications as soft materials due to their self-assembly and diversity of… Continue reading Directing the phase behavior of polyelectrolyte complexes using chiral patterned peptides
2016 / PLoS ONE
The S100 proteins are a large family of signaling proteins that play critical roles in biology and disease. Many S100… Continue reading Multiple Evolutionary Origins of Ubiquitous Cu2+ and Zn2+ Binding in the S100 Protein Family
2017 / International Journal of Biological Macromolecules
Under physical or chemical stress, proteins tend to form aggregates either highly ordered (amyloid) or unordered (amorphous) causing many pathological… Continue reading Polyols (Glycerol and Ethylene glycol) mediated amorphous aggregate inhibition and secondary structure restoration of metalloproteinase-conalbumin (ovotransferrin)
2016 / PNAS
Protein biogenesis is tightly linked to protein quality control (PQC). The role of PQC machinery in recognizing faulty polypeptides is… Continue reading Recognition of enzymes lacking bound cofactor by protein quality control
2016 / Biochemistry
Extracts of Alzheimer’s disease (AD) brain that contain what appear to be SDS-stable amyloid β-protein (Aβ) dimers potently block LTP… Continue reading The aggregation paths and products of Aβ42 dimers are distinct from Aβ42 monomer
2016 / The EMBO Journal
DNGR‐1 is receptor expressed by certain dendritic cell (DC) subsets and by DCprecursors in mouse. It possesses a C‐type lectin‐like domain… Continue reading A pH‐ and ionic strength‐dependent conformational change in the neck region regulates DNGR‐1 function in dendritic cells
2016 / Scientific Reports
Resveratrol is one of the most widely studied bioactive plant polyphenols which possesses anticancer properties. Previously we have reported synthesis,… Continue reading A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells
2016 / Journal of Physical Chemistry B
Accumulation and aggregation of amyloid β-protein (Aβ) play an important role in the pathogenesis of Alzheimer’s disease. There has been… Continue reading Hematoxylin Inhibits Amyloid β-Protein Fibrillation and Alleviates Amyloid-Induced Cytotoxicity
2016 / The Protein Journal
Coomassie Brilliant Blue interacts with proteins and even though the interactions exhibit variation due to the amino acid content, reported… Continue reading A Dynamic Interaction of Coomassie Dye with the Glycine Transporters N-termini
2017 / Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Combination therapy with more than one therapeutic agent can improve therapeutic efficiency and decrease drug resistance. In this study, the… Continue reading Competitive binding of (−)-epigallocatechin-3-gallate and 5-fluorouracil to human serum albumin: A fluorescence and circular dichroism study
