KnowledgeBase Articles Archive

Co-precipitation synthesis and characterization of Co doped SnO2 NPs, HSA interaction via various spectroscopic techniques and their antimicrobial and photocatalytic activities

2017 / International Journal of Biological Macromolecules

Sn1-xCoxO2 (x = 0.00, 0.01, 0.03, 0.05) nanoparticles (NPs) of average size ∼30–40 nm were synthesized by co-precipitation method. The interaction of Co doped… Continue reading Co-precipitation synthesis and characterization of Co doped SnO2 NPs, HSA interaction via various spectroscopic techniques and their antimicrobial and photocatalytic activities

Mastoparan is a membranolytic anti-cancer peptide that works synergistically with gemcitabine in a mouse model of mammary carcinoma

2016 / Biochimica et Biophysica Acta (BBA) - Biomembranes

Anti-cancer peptides (ACPs) are small cationic and hydrophobic peptides that are more toxic to cancer cells than normal cells. ACPs… Continue reading Mastoparan is a membranolytic anti-cancer peptide that works synergistically with gemcitabine in a mouse model of mammary carcinoma

Light induced structural changes of the photoprotein mnemiopsin: Characterization and contribution in photoinactivation

2016 / Journal of Photochemistry and Photobiology B: Biology

Mnemiopsin, an EF-hand Ca2+ binding photoprotein isolated from luminous ctenophoreMnemiopsis leidyi, emits blue light from its chromophore, coelenterazine, which is non-covalently… Continue reading Light induced structural changes of the photoprotein mnemiopsin: Characterization and contribution in photoinactivation

Azaphilones isolated from an alga-derived fungus Penicillium sp. ZJ-27

2016 / Phytochemistry Letters

Four new azaphilones, peniazaphilones A–D (1–4), together with four analogues (5–8), were isolated from the alga-derived fungus Penicillium sp. ZJ-27. The structures… Continue reading Azaphilones isolated from an alga-derived fungus Penicillium sp. ZJ-27

Sesquiterpenoids from the Chinese endangered plant Manglietia aromatica

2016 / Phytochemistry Letters

One new bourbonane-type (1) and one new cadinane-type (2) sesquiterpenoids, along with one known aromodendrane-type (3) and five known megastigmane-type… Continue reading Sesquiterpenoids from the Chinese endangered plant Manglietia aromatica

Interactions and cooperativity between P-glycoprotein structural domains determined by thermal unfolding provides insights into its solution structure and function

2016 / Biochimica et Biophysica Acta (BBA) - Biomembranes

Structural changes in mouse P-glycoprotein (Pgp) induced by thermal unfolding were studied by differential scanning calorimetry (DSC), circular dichroism and… Continue reading Interactions and cooperativity between P-glycoprotein structural domains determined by thermal unfolding provides insights into its solution structure and function

Relocation of a biological photosensitizer from non-ionic micellar carrier to DNA: A multispectroscopic investigation

2016 / Biophysical Chemistry

Relocation of a bioactive photosensitizer, namely phenosafranin (PSF), from the phenazinium family, has been demonstrated from non-ionic micellar carrier to… Continue reading Relocation of a biological photosensitizer from non-ionic micellar carrier to DNA: A multispectroscopic investigation

Purification, preliminary X-ray crystallography and biophysical studies of triose phosphate isomerase-β-globin subunit complex

2016 / International Journal of Biological Macromolecules

Triose phosphate isomerase (TIM) is a cytoplasmic enzyme of prime importance in the mammalian glycolytic pathway. It has a major… Continue reading Purification, preliminary X-ray crystallography and biophysical studies of triose phosphate isomerase-β-globin subunit complex

Neo-tanshinlactone D-Ring Modified Novel analogues Induce Apoptosis in Human Breast Cancer Cell via DNA Damage

2016 / Bioorganic & Medicinal Chemistry

Neo-tanshinlactone (NTL) a natural product is known for its specificity and selectivity towards the breast cancer cells. By NTL D-ring… Continue reading Neo-tanshinlactone D-Ring Modified Novel analogues Induce Apoptosis in Human Breast Cancer Cell via DNA Damage

5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one (naringenin): X-ray diffraction structures of the naringenin enantiomers and DFT evaluation of the preferred ground-state structures and thermodynamics for racemization

2016 / Journal of Molecular Structure

The R- and S-enantiomers of naringenin were separated by chiral HPLC and the absolute configuration of each enantiomer was established… Continue reading 5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one (naringenin): X-ray diffraction structures of the naringenin enantiomers and DFT evaluation of the preferred ground-state structures and thermodynamics for racemization

Characterization of folding intermediates during urea-induced denaturation of human carbonic anhydrase II

2016 / International Journal of Biological Macromolecules

Knowledge of folding/unfolding pathway is fundamental basis to study protein structure and stability. Human carbonic anhydrase II (HCAII) is a… Continue reading Characterization of folding intermediates during urea-induced denaturation of human carbonic anhydrase II

Light-induced oxidation of the telomeric G4 DNA in complex with Zn(II) tetracarboxymethyl porphyrin

2016 / Nucleic Acids Research

Structure-specific ligands are convenient tools for the recognition, targeting or probing of noncanonical DNA structures. Porphyrin derivatives exhibit a preference… Continue reading Light-induced oxidation of the telomeric G4 DNA in complex with Zn(II) tetracarboxymethyl porphyrin

An improved non-denaturing method for the purification of spiralin, the main membrane lipoprotein of the pathogenic bacteria Spiroplasma melliferum

2016 / Journal of Chromatography B

Spiralin is the most abundant protein of several species of spiroplasmas, helical, motile bacteria pathogenic for arthropods and plants. This… Continue reading An improved non-denaturing method for the purification of spiralin, the main membrane lipoprotein of the pathogenic bacteria Spiroplasma melliferum

Molecular mechanism of the binding of 3,4,5-tri-O-caffeoylquinic acid to human serum albumin: Saturation transfer difference NMR, multi-spectroscopy, and docking studies

2016 / Journal of Photochemistry and Photobiology B: Biology

As a natural dietary polyphenol, 3,4,5-tri-O-caffeoylquinic acid (3,4,5-triCQA) exhibits numerous stronger pharmacological activities than that of its analogues. Studies on… Continue reading Molecular mechanism of the binding of 3,4,5-tri-O-caffeoylquinic acid to human serum albumin: Saturation transfer difference NMR, multi-spectroscopy, and docking studies

Interaction of phospholipase C with liposome: A conformation transition of the enzyme is critical and specific to liposome composition for burst hydrolysis and fusion in concert

2016 / Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Phospholipase C (PLC)1 is known to help the pathogen B. cereus entry to the host cell and human PLC is over expressed in… Continue reading Interaction of phospholipase C with liposome: A conformation transition of the enzyme is critical and specific to liposome composition for burst hydrolysis and fusion in concert

Characterization of culture filtrate proteins Rv1197 and Rv1198 of ESAT-6 family from Mycobacterium tuberculosis H37Rv

2016 / Biochimica et Biophysica Acta (BBA) - General Subjects

We have characterized two immunogenic proteins, Rv1197 and Rv1198, of the Esx-5 system of the ESAT-6 family of Mycobacterium tuberculosis… Continue reading Characterization of culture filtrate proteins Rv1197 and Rv1198 of ESAT-6 family from Mycobacterium tuberculosis H37Rv

PrxQ B from Mycobacterium tuberculosis is a monomeric, thioredoxin-dependent and highly efficient fatty acid hydroperoxide reductase

2016 / Free Radical Biology and Medicine

Mycobacterium tuberculosis (M. tuberculosis) is the intracellular bacterium responsible for tuberculosis disease (TD). Inside the phagosomes of activated macrophages, M. tuberculosis is exposed… Continue reading PrxQ B from Mycobacterium tuberculosis is a monomeric, thioredoxin-dependent and highly efficient fatty acid hydroperoxide reductase

Interaction of the minocycline with extracelluar protein and intracellular protein by multi-spectral techniques and molecular docking

2016 / Journal of Molecular Structure

The interaction of minocyeline (MNC) with extracelluar protein (lysozyme, LYSO) or intracellular protein (bovine hemoglobin, BHb) was investigated using multi-spectral… Continue reading Interaction of the minocycline with extracelluar protein and intracellular protein by multi-spectral techniques and molecular docking

Purification and characterization of Pseudomonas aeruginosa LasR expressed in acyl-homoserine lactone free Escherichia coli cultures

2016 / Protein Expression and Purification

Quorum sensing systems are essential for bacterial communication. We report here the purification and characterization of the Pseudomonas aeruginosa LasR quorum sensing… Continue reading Purification and characterization of Pseudomonas aeruginosa LasR expressed in acyl-homoserine lactone free Escherichia coli cultures

Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum scabrum

2016 / Fitoterapia

Four new polyisoprenylated benzoylphloroglucinol derivatives, hyperscabrones J-M (1–4), were isolated from the air-dried aerial parts of Hypericum scabrum. Their structures were elucidated… Continue reading Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum scabrum

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