Leah Pandiscia, PhD
July 28, 2017
Five new compounds including three dimeric chromanones (1–3), one cyclohexenone (4) and one benzamide (5), together with four known metabolites,… Continue reading Dimeric chromanone, cyclohexenone and benzamide derivatives from the endophytic fungus Xylaria sp. PSU-H182
Leah Pandiscia, PhD
July 28, 2017
(+)-Terrein has a potential application for drug discovery. To improve the yield of (+)-terrein, two-level Plackett–Burman design and response surface… Continue reading Improving the yield of (+)-terrein from the salt-tolerant Aspergillus terreusPT06-2
Leah Pandiscia, PhD
July 28, 2017
Recognition of methylated DNA sites would be useful strategy due to the important roles of methylation in disease occurrence and… Continue reading Spectroscopic Study of CpG Alternating DNA-Methylene Blue Interaction for Methylation Detection
Leah Pandiscia, PhD
July 28, 2017
The products of the reaction between cisplatin (CDDP) and the model protein hen egg white lysozyme (HEWL) at 20, 37… Continue reading Effect of temperature on the interaction of cisplatin with the model protein hen egg white lysozyme
Leah Pandiscia, PhD
July 28, 2017
Polyphenol oxidase from the marine bacterium Marinomonas mediterranea (MmPPOA) is a membrane-bound, blue, multi-copper laccase of 695 residues. It possesses peculiar properties… Continue reading Different recombinant forms of polyphenol oxidase A, a laccase from Marinomonas mediterranea
Leah Pandiscia, PhD
July 28, 2017
Amylin, a small peptide co-secreted from pancreatic β-cells together with insulin, is one of the hallmarks of type II diabetes.… Continue reading Coordination of Zn2+ and Cu2+ to the membrane disrupting fragment of amylin
Leah Pandiscia, PhD
July 28, 2017
Overexpression of domains of a human protein using recombinant DNA technology has been challenging because individual domains intend to accumulate… Continue reading Overexpression and purification of folded domain of prostate cancer related proteins MSMB and PSA
Leah Pandiscia, PhD
July 28, 2017
To investigate in vitro the innate immune response to accelerated stress-induced aggregates of intravenous immunoglobulin (IGIV) using a well-defined human cell-line model,… Continue reading Physical Characterization and Innate Immunogenicity of Aggregated Intravenous Immunoglobulin (IGIV) in an In Vitro Cell-Based Model
Leah Pandiscia, PhD
July 28, 2017
PEGylation is the most widely used method to chemically modify protein biopharmaceuticals, but surprisingly limited public data is available on… Continue reading Large-Scale Biophysical Evaluation of Protein PEGylation Effects: In Vitro Properties of 61 Protein Entities
Leah Pandiscia, PhD
July 28, 2017
Nanoparticles (NPs) are extensively being used in modern nano-based therapies and nano-protein formulations. The exposures to these comprehensively used NPs… Continue reading Systematic elucidation of interactive unfolding and corona formation of bovine serum albumin with cobalt ferrite nanoparticles
Leah Pandiscia, PhD
July 28, 2017
Peptaibols are peculiar peptides produced by fungi as weapons against other microorganisms. Previous studies showed that peptaibols are promising peptide-based… Continue reading The rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach
Leah Pandiscia, PhD
July 28, 2017
The rationale for the preparation of DNA-templated gold nanoclusters (DNA-Au NCs) has not been well understood, thereby slowing down the… Continue reading Pre-Incubation of Auric Acid with DNA Is Unnecessary for the Formation of DNA-Templated Gold Nanoclusters
Leah Pandiscia, PhD
July 28, 2017
The prevalence of reactive oxygen species (ROS) production and the enzyme-containing intracellular environment could lead to the fluorescence quenching of… Continue reading Ultrastable BSA-capped gold nanoclusters with a polymer-like shielding layer against reactive oxygen species in living cells
Leah Pandiscia, PhD
July 28, 2017
Cyclic tri-β-peptide having tetrathiafulvalene (TTF) at the side chain was synthesized to prepare a peptide nanotube aligning TTF side chains… Continue reading Electronic Properties of Tetrathiafulvalene-Modified Cyclic-β-Peptide Nanotube
Leah Pandiscia, PhD
July 28, 2017
Two-step self-assembly of two different lipids and a short polyethylene glycol (PEG) unit selectively produced molecular monolayer nanotubes with 7–9… Continue reading Short polyethylene glycol chains densely bound to soft nanotube channels for inhibition of protein aggregation
Leah Pandiscia, PhD
July 28, 2017
Effects of reactive oxygen species (ROS) on the optical, structural, and biological properties ofCordyceps pruinosa spores were studied. Both the atmospheric… Continue reading Effects of reactive oxygen species on the biological, structural, and optical properties of Cordyceps pruinosa spores
Leah Pandiscia, PhD
July 28, 2017
The self-assembling properties of thermally-sensitive amphiphilic elastin-like multiblock recombinamers have been combined with the capacities of calcium phosphate binding of… Continue reading Formation of calcium phosphate nanostructures under the influence of self-assembling hybrid elastin-like-statherin recombinamers
Leah Pandiscia, PhD
July 28, 2017
Recent findings suggest that the senile plaques in Alzheimer’s disease may contain soluble amyloid-β peptide (Aβ) fibril precursors along with… Continue reading Aβ40 has a subtle effect on Aβ42 protofibril formation, but to a lesser degree than Aβ42 concentration, in Aβ42/Aβ40 mixtures
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
