Found 9617 Results / Page 451 of 481
2016 / Journal of Photochemistry and Photobiology B: Biology
In this study, we have investigated the binding affinity of the newly approved tyrosine kinase inhibitor nintedanib (NIB) with human… Continue reading Interplay of multiple interaction forces: Binding of tyrosine kinase inhibitor nintedanib with human serum albumin
2016 / Colloids and Surfaces B: Biointerfaces
Cationic antimicrobial peptides (CAMPs) represent important self defense molecules in many organisms, including humans. These peptides have a broad spectrum… Continue reading Role of amphipathicity and hydrophobicity in the balance between hemolysis and peptide–membrane interactions of three related antimicrobial peptides
2016 / European Journal of Pharmaceutics and Biopharmaceutics
Newly discovered active macromolecules are highly promising for therapy, but poor bioavailability hinders their oral use. Microencapsulation approaches, such as… Continue reading On prilled Nanotubes-in-Microgel Oral Systems for protein delivery
2011 / Journal of Pharmaceutical Sciences
Circular dichroism (CD) spectroscopy is routinely used in the biopharmaceutical industry to study the effects of manufacturing, formulation, and storage… Continue reading Applications of circular dichroism (CD) for structural analysis of proteins: qualification of near‐ and far‐UV CD for protein higher order structural analysis
2011 / Journal of Pharmaceutical Sciences
The major goal of this study was to develop the biodegradable and biocompatible thermosensitive polylactic acid–polyethylene glycol–polylactic acid triblock copolymer-based… Continue reading Basal level insulin delivery: In vitro release, stability, biocompatibility, and in vivo absorption from thermosensitive triblock copolymers
2010 / Journal of Pharmaceutical Sciences
Aggregation is a critical issue that hampers the development of monoclonal antibody therapeutics (Mabs). Traditionally, aggregation is considered a process… Continue reading Use of a folding model and in situ spectroscopic techniques for rational formulation development and stability testing of monoclonal antibody therapeutics *
2009 / Journal of Pharmaceutical Sciences
wo major aggregation pathways observed in an IgG2 molecule are described. Different aggregate species generated by long-term incubation of the… Continue reading Elucidation of Two Major Aggregation Pathways in an IgG2 Antibody
2009 / Journal of Pharmaceutical Sciences
he photodegradation of a human IgG1 monoclonal antibody has been examined in a high concentration (100 mg/mL) liquid formulation. It… Continue reading Characterization of the photodegradation of a human IgG1 monoclonal antibody formulated as a high-concentration liquid dosage form
2009 / Journal of Pharmaceutical Sciences
Silicone oil, which is used as a lubricant or coating in devices such as syringes, needles and pharmaceutical containers, has… Continue reading Silicone Oil- and Agitation-Induced Aggregation of a Monoclonal Antibody in Aqueous Solution
2009 / Journal of Pharmaceutical Sciences
We studied the physical and biophysical affects of the nonionic surfactants polysorbate 20 and 80 and their mechanism of interaction… Continue reading Physical and biophysical effects of polysorbate 20 and 80 on darbepoetin alfa
2016 / Biochemical and Biophysical Research Communications
ApoA-I mimetics are short synthetic peptides that contain an amphipathic α-helix and stimulate cholesterol efflux by the ABCA1 transporter in… Continue reading Amphipathic polyproline peptides stimulate cholesterol efflux by the ABCA1 transporter
2016 / Innovative Food Science and Emerging Technologies
The effects of high hydrostatic pressure (HHP) treatment on the structural, allergenicity and functional properties of ginkgo seed protein (GSP)… Continue reading Effects of high hydrostatic pressure treatment on structural, allergenicity, and functional properties of proteins from ginkgo seeds
2016 / Journal of Molecular Biology
The misfolding of the prion protein (PrP) to aggregated forms is linked to several neurodegenerative diseases. Misfolded oligomeric forms of… Continue reading Unraveling the Molecular Mechanism of pH-Induced Misfolding and Oligomerization of the Prion Protein
2016 / Environmental Microbiology
Alloxan is an environmental food contaminant that causes DNA damage in living cells and induces hyperglycemia. Pelargonidin (PG), an active… Continue reading Nanopharmaceutical approach using pelargonidin towards enhancement of efficacy for prevention of alloxan-induced DNA damage in L6 cells via activation of PARP and p53
2016 / Food Hydrocolloids
Bovine α-lactalbumin (α-La) and lysozyme (Lys), two globular proteins with highly homologous tertiary structures and opposite isoelectric points, were used… Continue reading Design of bio-based supramolecular structures through self-assembly of α-lactalbumin and lysozyme
2016 / Journal of Inorganic Biochemistry
In the search for novel platinum-based anticancer therapeutic agents, we have recently established a structural motif of (O,S) bidentate ligands… Continue reading Elucidating the reactivity of Pt(II) complexes with (O,S) bidentate ligands towards DNA model systems ☆
2016 / Colloids and Surfaces B: Biointerfaces
At least 30 different human proteins can fold abnormally to form the amyloid deposits that are associated with a number… Continue reading Amyloid fibrillogenesis of lysozyme is suppressed by a food additive brilliant blue FCF
2016 / Innovative Food Science and Emerging Technologies
In this work, soybean glycinin was treated by high intensity ultrasound (HIU; 20 kHz at 80 W cm− 2 from 0 to 40 min) in three… Continue reading Effect of high intensity ultrasound on physicochemical and functional properties of soybean glycinin at different ionic strengths
2016 / Journal of Molecular Structure
Tedizolid is the newest antibacterial agent from the oxazolidinone class. For its identification, FT-IR (2000–400 cm−1) and Raman (2000–400 cm−1) analyses were… Continue reading Infrared, Raman and ultraviolet with circular dichroism analysis and theoretical calculations of tedizolid
2016 / Virus Research
We have obtained a chimeric protein containing the ectodomains of hepatitis C virus (HCV) envelope proteins but lacking the region… Continue reading The deletion of residues 268-292 of E1 impairs the ability of HCV envelope proteins to induce pore formation
