The interaction between 13-phenylalkyl and 13-diphenylalkyl berberine derivatives (NAX) and human telomeric DNA G4 structures has been investigated by both… Continue reading Solution and Solid-State Analysis of Binding of 13-Substituted Berberine Analogues to Human Telomeric G-quadruplexes
Leah Pandiscia, PhD
July 28, 2017
Mitomycin C (MC) and Decarbamoylmitomycin C (DMC) – a derivative of MC lacking the carbamate on C10 – are DNA… Continue reading Synthesis of Mitomycin C and Decarbamoylmitomycin C N2deoxyguanosine-adducts
Leah Pandiscia, PhD
July 28, 2017
In this study, novel 1-methylpropargyl alcohol derivatives containing leucine side groups on their side chains were successfully synthesized and polymerized… Continue reading Application of pH-responsive methylpropargyl leucine polymer in enantioselective crystallization
Leah Pandiscia, PhD
July 28, 2017
The mechanism of action of antimicrobial peptides depends on physicochemical properties such as structure, concentration, and oligomerization. Here, we focused… Continue reading Effect of dimerization on the mechanism of action of aurein 1.2
Leah Pandiscia, PhD
July 28, 2017
The aim of this study is to investigate the folding reaction of human frataxin, whose deficiency causes the neurodegenerative disease… Continue reading Human Frataxin Folds Via an Intermediate State. Role of the C-Terminal Region
Leah Pandiscia, PhD
July 28, 2017
Pendimethalin (PND) is a systemic herbicide widely used on rice, cotton, peas, wheat, potatoes, fruits, nuts and other residential and… Continue reading Binding properties of pendimethalin herbicide to DNA: multispectroscopic and molecular docking approaches
Leah Pandiscia, PhD
July 28, 2017
Phosvitin is a unique highly phosphorylated protein that plays a role in the regulation of calcification. We conducted a comprehensive… Continue reading Calcium binding characteristics and structural changes of phosvitin
Leah Pandiscia, PhD
July 28, 2017
Nonplanar conformations of pyrazine-fused ZnII diporphyrins could be controlled by the choice of themeso-aryl substituents and an axial ligand on the… Continue reading Control of Conformation and Chirality of Nonplanar π-Conjugated Diporphyrins Using Substituents and Axial Ligands
Leah Pandiscia, PhD
July 28, 2017
Photocurrent generation is observed with D−π–A type oligo(phenyleneethynylene) (OPE) physically contacting gold substrate. The OPE is conjugated with helical peptides,… Continue reading Prevailing Photocurrent Generation of D−π–A Type Oligo(phenyleneethynylene) in Contact with Gold over Dexter-Type Energy-Transfer Quenching
Leah Pandiscia, PhD
July 28, 2017
Photosynthetic organisms need protection against excessive light. By using non-photochemical quenching, where the excess light is converted into heat, the… Continue reading Functional and structural characterization of domain truncated violaxanthin de-epoxidase
Leah Pandiscia, PhD
July 28, 2017
Generally, small peptides by themselves are weak to induce antibody responses. Toll-like receptor (TLR) ligands are attractive candidates of vaccine… Continue reading 6-(4-Amino-2-butyl-imidazoquinolyl)-norleucine: Toll-like receptor 7 and 8 agonist amino acid for self-adjuvanting peptide vaccine
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Vanillin a major component of vanilla bean extract is commonly used a natural flavoring agent. Glycation is known to induce… Continue reading Vanillin restrains non-enzymatic glycation and aggregation of albumin by chemical chaperone like function
Leah Pandiscia, PhD
July 28, 2017
Low-generation viologen-phosphorous dendrimers (VPDs) can be exploited as novel therapeutic agents, since they efficiently inhibit aggregation of amyloid-β into fibrils… Continue reading Structure and binding thermodynamics of viologen-phosphorous dendrimers to human serum albumin: A combined computational/experimental investigation
Leah Pandiscia, PhD
July 28, 2017
The global ever-growing concerns about multi-drug resistant (MDR) microbes leads to urgent demands for exploration of new antibiotics including antimicrobial… Continue reading Identification and functional characterization of an uncharacterized antimicrobial peptide from a ciliate Paramecium caudatum
Leah Pandiscia, PhD
July 28, 2017
Although phototherapy was introduced as early as 1950’s, the potential biological effects of bilirubin photoisomers (PI) generated during phototherapy remain… Continue reading The Biological Effects of Bilirubin Photoisomers
Leah Pandiscia, PhD
July 28, 2017
Neuronal precursor cell-expressed developmentally down-regulated 4 (Nedd4) was the first ubiquitin protein ligase identified to interact with connexin43 (Cx43), and… Continue reading Structural Studies of the Nedd4 WW Domains and their Selectivity for the Cx43 Carboxyl-terminus*
Leah Pandiscia, PhD
July 28, 2017
Knowledge on domain swapping in vitro is increasing, but domain swapping may not occur regularly in vivo, and its information in cells is… Continue reading Domain swapping oligomerization of thermostable c-type cytochrome in E. colicells
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017